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• W3134555729 startingPage "263485352199938" @default.
• W3134555729 abstract "Primary plasma cell leukemia (PCL) is a rare and aggressive variant of multiple myeloma (MM). PCL is characterized by peripheral blood involvement by malignant plasma cells and an aggressive clinical course leading to poor survival. There is considerable overlap between MM and PCL with respect to clinical, immunophenotypic, and cytogenetic features, but circulating plasma cell count exceeding 20% of peripheral blood leukocytes or an absolute plasma cell count of >2000/mm 3 distinguishes it from MM. After initial stabilization and diagnosis confirmation, treatment of PCL in a fit patient typically includes induction combination chemotherapy containing novel agents typically, with proteasome inhibitors (such as bortezomib) and immunomodulatory drugs (eg, lenalidomide), followed by autologous hematopoietic stem cell transplant (HSCT) and multidrug maintenance therapy using novel agents post-HSCT. Long-term outcomes have improved employing this strategy but the prognosis for non-HSCT candidates remains poor and new approaches are needed for such PCL patients not eligible for HSCT. Here, we report a case of primary PCL, and a comprehensive and up to date review of the literature for diagnosis and management of PCL. We also present the findings of Positron Emission Tomography (PET) scan. Since PCL is often associated with extra-medulary disease, including PET scan at the time of staging and restaging may be a novel approach particularly to evaluate the extra-medullary disease sites." @default.
• W3134555729 created "2021-03-15" @default.
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• W3134555729 date "2021-01-01" @default.
• W3134555729 modified "2023-09-22" @default.
• W3134555729 title "Management of Primary Plasma Cell Leukemia Remains Challenging Even in the Era of Novel Agents" @default.
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• W3134555729 doi "https://doi.org/10.1177/2634853521999389" @default.
• W3134555729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7917418" @default.
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• W3134555729 hasPublicationYear "2021" @default.
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