FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134559423> ?p ?o ?g. }

• W3134559423 endingPage "519" @default.
• W3134559423 startingPage "510" @default.
• W3134559423 abstract "Intra-tumor heterogeneity is widely accepted as one of the key factors, which hinders cancer patients from achieving full recovery. Especially, cancer stem cells (CSCs) may exhibit self-renewal capacity, which makes it harder for complete elimination of tumor. Therefore, simultaneously inhibiting CSCs and non-CSCs in tumors becomes a promising strategy to obtain sustainable anticancer efficacy. Salinomycin (Sal) was reported to be critical to inhibit CSCs. However, the poor bioavailability and catastrophic side effects brought about limitations to clinical practice. To solve this problem, we previously constructed gelatinase-stimuli nanoparticles composed of nontoxic, biocompatible polyethylene glycol-polycaprolactone (PEG-PCL) copolymer with a gelatinase-cleavable peptide Pro-Val-Gly-Leu-Iso-Gly (PVGLIG) inserted between the two blocks of the copolymer. By applying our smart gelatinase-responsive nanoparticles for Sal delivery, we have demonstrated specific accumulation in tumor, anti-CSCs ability and reduced toxicity of Sal-NPs in our previous study. In the present study, we synthesized Sal-Docetaxel-loaded gelatinase-stimuli nanoparticles (Sal-Doc NP) and confirmed single emulsion as the optimal method of producing Sal-Doc NPs (Sal-Doc SE-NP) in comparison with nanoprecipitation. Sal-Doc SE-NPs inhibited both CSCs and non-CSCs in mice transplanted with cervical cancer, and might be associated with enhanced restriction of epithelial-mesenchymal transition (EMT) pathway. Besides, the tumorigenic capacity and growing speed were obviously suppressed in Sal-Doc-SE-NPs-treated group in rechallenge experiment. Our results suggest that Sal-Doc-loaded gelatinase-stimuli nanoparticles could be a promising strategy to enhance antitumor efficacy and reduce side effects by simultaneously suppressing CSCs and non-CSCs." @default.
• W3134559423 created "2021-03-15" @default.
• W3134559423 creator A5004716187 @default.
• W3134559423 creator A5013653434 @default.
• W3134559423 creator A5030065149 @default.
• W3134559423 creator A5042711716 @default.
• W3134559423 creator A5045690123 @default.
• W3134559423 creator A5045723123 @default.
• W3134559423 creator A5049630854 @default.
• W3134559423 creator A5065243448 @default.
• W3134559423 creator A5071375088 @default.
• W3134559423 creator A5077622749 @default.
• W3134559423 creator A5085558954 @default.
• W3134559423 date "2021-01-01" @default.
• W3134559423 modified "2023-10-17" @default.
• W3134559423 title "Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells" @default.
• W3134559423 cites W1515566746 @default.
• W3134559423 cites W1868543250 @default.
• W3134559423 cites W1969787235 @default.
• W3134559423 cites W1983933325 @default.
• W3134559423 cites W1987294972 @default.
• W3134559423 cites W2002601186 @default.
• W3134559423 cites W2017865089 @default.
• W3134559423 cites W2020623713 @default.
• W3134559423 cites W2022436212 @default.
• W3134559423 cites W2024520801 @default.
• W3134559423 cites W2031886832 @default.
• W3134559423 cites W2089818916 @default.
• W3134559423 cites W2100603034 @default.
• W3134559423 cites W2101890232 @default.
• W3134559423 cites W2120656656 @default.
• W3134559423 cites W2121248318 @default.
• W3134559423 cites W2126638918 @default.
• W3134559423 cites W2161083472 @default.
• W3134559423 cites W2169829820 @default.
• W3134559423 cites W2305146800 @default.
• W3134559423 cites W2324393204 @default.
• W3134559423 cites W2409318264 @default.
• W3134559423 cites W2415528931 @default.
• W3134559423 cites W2555680224 @default.
• W3134559423 cites W2591193661 @default.
• W3134559423 cites W2734007155 @default.
• W3134559423 cites W2738725566 @default.
• W3134559423 cites W2777786283 @default.
• W3134559423 cites W2810069728 @default.
• W3134559423 cites W2888789064 @default.
• W3134559423 cites W2891681637 @default.
• W3134559423 cites W2893794857 @default.
• W3134559423 cites W2901166752 @default.
• W3134559423 cites W2907245943 @default.
• W3134559423 cites W2921303823 @default.
• W3134559423 cites W2927225477 @default.
• W3134559423 cites W2936513263 @default.
• W3134559423 cites W2944229672 @default.
• W3134559423 cites W2986097069 @default.
• W3134559423 cites W2989722493 @default.
• W3134559423 cites W2995689405 @default.
• W3134559423 cites W3006152082 @default.
• W3134559423 cites W3007276105 @default.
• W3134559423 cites W3008528195 @default.
• W3134559423 cites W3039653120 @default.
• W3134559423 cites W3047995724 @default.
• W3134559423 cites W3092265519 @default.
• W3134559423 cites W3097155613 @default.
• W3134559423 cites W3097381587 @default.
• W3134559423 cites W3097636147 @default.
• W3134559423 doi "https://doi.org/10.1080/10717544.2021.1886378" @default.
• W3134559423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7935125" @default.
• W3134559423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33657950" @default.
• W3134559423 hasPublicationYear "2021" @default.
• W3134559423 type Work @default.
• W3134559423 sameAs 3134559423 @default.
• W3134559423 citedByCount "18" @default.
• W3134559423 countsByYear W31345594232021 @default.
• W3134559423 countsByYear W31345594232022 @default.
• W3134559423 countsByYear W31345594232023 @default.
• W3134559423 crossrefType "journal-article" @default.
• W3134559423 hasAuthorship W3134559423A5004716187 @default.
• W3134559423 hasAuthorship W3134559423A5013653434 @default.
• W3134559423 hasAuthorship W3134559423A5030065149 @default.
• W3134559423 hasAuthorship W3134559423A5042711716 @default.
• W3134559423 hasAuthorship W3134559423A5045690123 @default.
• W3134559423 hasAuthorship W3134559423A5045723123 @default.
• W3134559423 hasAuthorship W3134559423A5049630854 @default.
• W3134559423 hasAuthorship W3134559423A5065243448 @default.
• W3134559423 hasAuthorship W3134559423A5071375088 @default.
• W3134559423 hasAuthorship W3134559423A5077622749 @default.
• W3134559423 hasAuthorship W3134559423A5085558954 @default.
• W3134559423 hasBestOaLocation W31345594231 @default.
• W3134559423 hasConcept C109523444 @default.
• W3134559423 hasConcept C121608353 @default.
• W3134559423 hasConcept C126322002 @default.
• W3134559423 hasConcept C171250308 @default.
• W3134559423 hasConcept C185592680 @default.
• W3134559423 hasConcept C192562407 @default.
• W3134559423 hasConcept C2776232661 @default.
• W3134559423 hasConcept C2776964284 @default.
• W3134559423 hasConcept C2777877089 @default.

• next