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• W3134601836 abstract "Fluoxetine is commonly prescribed during pregnancy but developmental exposure to the drug, like infection, is associated with sex-specific behavioral changes in the offspring. We evaluated the effects of Fluoxetine on production of biomarkers for inflammation (pro/anti-inflammatory cytokines) and neurodevelopment (Brain-Derived Neurotrophic Factor, BDNF) in the presence and absence of infection in female and male placenta explant cultures. In addition to minor anti-inflammatory effects of the drug, Fluoxetine had significant sex- and infection-dependent effects on BDNF production. Further studies are needed to determine the extent to which these observed changes occur in vivo and their impact on pregnancy and neurodevelopmental outcomes." @default.
• W3134601836 created "2021-03-15" @default.
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• W3134601836 date "2021-04-01" @default.
• W3134601836 modified "2023-10-18" @default.
• W3134601836 title "Short communication: Ex-vivo effects of fluoxetine on production of biomarkers for inflammation and neurodevelopment by the placenta" @default.
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• W3134601836 doi "https://doi.org/10.1016/j.placenta.2021.02.018" @default.
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