Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134615608> ?p ?o ?g. }
- W3134615608 endingPage "6441" @default.
- W3134615608 startingPage "6420" @default.
- W3134615608 abstract "Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, SIRT6 levels/activity decline, which is accentuated in Alzheimer's patients. To understand SIRT6 roles in transcript pattern changes, we analyzed transcriptomes of young WT, old WT and young SIRT6-KO mice brains, and found changes in gene expression related to healthy and pathological aging. In addition, we traced these differences in human and mouse samples of Alzheimer's and Parkinson's diseases, healthy aging and calorie restriction (CR). Our results define four gene expression categories that change with age in a pathological or non-pathological manner, which are either reversed or not by CR. We found that each of these gene expression categories is associated with specific transcription factors, thus serving as potential candidates for their category-specific regulation. One of these candidates is YY1, which we found to act together with SIRT6 regulating specific processes. We thus argue that SIRT6 has a pivotal role in preventing age-related transcriptional changes in brains. Therefore, reduced SIRT6 activity may drive pathological age-related gene expression signatures in the brain." @default.
- W3134615608 created "2021-03-15" @default.
- W3134615608 creator A5000590470 @default.
- W3134615608 creator A5009411804 @default.
- W3134615608 creator A5009547103 @default.
- W3134615608 creator A5019785229 @default.
- W3134615608 creator A5038422956 @default.
- W3134615608 creator A5061428121 @default.
- W3134615608 creator A5063593677 @default.
- W3134615608 creator A5071003851 @default.
- W3134615608 creator A5071406381 @default.
- W3134615608 creator A5091295712 @default.
- W3134615608 date "2021-03-09" @default.
- W3134615608 modified "2023-10-06" @default.
- W3134615608 title "Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6" @default.
- W3134615608 cites W1526667996 @default.
- W3134615608 cites W1527130221 @default.
- W3134615608 cites W1968170156 @default.
- W3134615608 cites W1979369962 @default.
- W3134615608 cites W1985039849 @default.
- W3134615608 cites W1994540097 @default.
- W3134615608 cites W1997838879 @default.
- W3134615608 cites W2007267313 @default.
- W3134615608 cites W2014655396 @default.
- W3134615608 cites W2016758992 @default.
- W3134615608 cites W2018986622 @default.
- W3134615608 cites W2020000978 @default.
- W3134615608 cites W2020057810 @default.
- W3134615608 cites W2020311873 @default.
- W3134615608 cites W2020541351 @default.
- W3134615608 cites W2039296833 @default.
- W3134615608 cites W2042716686 @default.
- W3134615608 cites W2044561872 @default.
- W3134615608 cites W2046691975 @default.
- W3134615608 cites W2055373932 @default.
- W3134615608 cites W2055655674 @default.
- W3134615608 cites W2080053685 @default.
- W3134615608 cites W2088677347 @default.
- W3134615608 cites W2089831590 @default.
- W3134615608 cites W2102029982 @default.
- W3134615608 cites W2113833510 @default.
- W3134615608 cites W2116296155 @default.
- W3134615608 cites W2121469024 @default.
- W3134615608 cites W2122598808 @default.
- W3134615608 cites W2126525177 @default.
- W3134615608 cites W2128016314 @default.
- W3134615608 cites W2128128648 @default.
- W3134615608 cites W2130410032 @default.
- W3134615608 cites W2139975324 @default.
- W3134615608 cites W2143730031 @default.
- W3134615608 cites W2153507013 @default.
- W3134615608 cites W2155631307 @default.
- W3134615608 cites W2158092222 @default.
- W3134615608 cites W2158616898 @default.
- W3134615608 cites W2159675211 @default.
- W3134615608 cites W2167351750 @default.
- W3134615608 cites W2167711201 @default.
- W3134615608 cites W2294654701 @default.
- W3134615608 cites W2305568100 @default.
- W3134615608 cites W2548864808 @default.
- W3134615608 cites W2552184863 @default.
- W3134615608 cites W2560701330 @default.
- W3134615608 cites W2577597748 @default.
- W3134615608 cites W2602238152 @default.
- W3134615608 cites W2751352835 @default.
- W3134615608 cites W2756263268 @default.
- W3134615608 cites W2763456538 @default.
- W3134615608 cites W2806961305 @default.
- W3134615608 cites W2888188888 @default.
- W3134615608 cites W2890169564 @default.
- W3134615608 cites W2898537938 @default.
- W3134615608 cites W2903826725 @default.
- W3134615608 cites W2919568651 @default.
- W3134615608 cites W2937386865 @default.
- W3134615608 cites W2969883164 @default.
- W3134615608 cites W2972368830 @default.
- W3134615608 cites W3002551330 @default.
- W3134615608 cites W3003838625 @default.
- W3134615608 cites W3038358120 @default.
- W3134615608 cites W3041733494 @default.
- W3134615608 cites W3046699218 @default.
- W3134615608 cites W3081651366 @default.
- W3134615608 cites W4229821940 @default.
- W3134615608 doi "https://doi.org/10.18632/aging.202755" @default.
- W3134615608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7993737" @default.
- W3134615608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33690173" @default.
- W3134615608 hasPublicationYear "2021" @default.
- W3134615608 type Work @default.
- W3134615608 sameAs 3134615608 @default.
- W3134615608 citedByCount "10" @default.
- W3134615608 countsByYear W31346156082021 @default.
- W3134615608 countsByYear W31346156082022 @default.
- W3134615608 countsByYear W31346156082023 @default.
- W3134615608 crossrefType "journal-article" @default.
- W3134615608 hasAuthorship W3134615608A5000590470 @default.
- W3134615608 hasAuthorship W3134615608A5009411804 @default.
- W3134615608 hasAuthorship W3134615608A5009547103 @default.
- W3134615608 hasAuthorship W3134615608A5019785229 @default.