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- W3134622114 abstract "A recent paper by Fang et al. examined the role of Agouti-Related Peptide (AgRP)-expressing neurons in the arcuate nucleus of the hypothalamus in mediating depressive-like behavior in mice. Chronic, but not acute stress, led to changes in neuronal excitability in AgRP neurons concomitant with the display of depressive-like behaviors, which were bidirectionally modulated using AgRP-selective chemogenetic manipulations. Together, these findings broaden our understanding of the diverse roles AgRP neurons play in driving motivational states, aside from their influence on hunger and feeding behaviors. A recent paper by Fang et al. examined the role of Agouti-Related Peptide (AgRP)-expressing neurons in the arcuate nucleus of the hypothalamus in mediating depressive-like behavior in mice. Chronic, but not acute stress, led to changes in neuronal excitability in AgRP neurons concomitant with the display of depressive-like behaviors, which were bidirectionally modulated using AgRP-selective chemogenetic manipulations. Together, these findings broaden our understanding of the diverse roles AgRP neurons play in driving motivational states, aside from their influence on hunger and feeding behaviors." @default.
- W3134622114 created "2021-03-15" @default.
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- W3134622114 date "2021-04-01" @default.
- W3134622114 modified "2023-09-23" @default.
- W3134622114 title "A Novel Role for Hypothalamic AgRP Neurons in Mediating Depressive Behavior" @default.
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- W3134622114 doi "https://doi.org/10.1016/j.tins.2021.02.005" @default.
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