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• W3134631141 endingPage "372" @default.
• W3134631141 startingPage "372" @default.
• W3134631141 abstract "Obesity is a global epidemic and coupled with the unprecedented growth of the world’s older adult population, a growing number of individuals are both old and obese. Whilst both ageing and obesity are associated with an increased prevalence of chronic health conditions and a substantial economic burden, evidence suggests that the coincident effects exacerbate negative health outcomes. A significant contributor to such detrimental effects may be the reduction in the contractile performance of skeletal muscle, given that poor muscle function is related to chronic disease, poor quality of life and all-cause mortality. Whilst the effects of ageing and obesity independently on skeletal muscle function have been investigated, the combined effects are yet to be thoroughly explored. Given the importance of skeletal muscle to whole-body health and physical function, the present study sought to provide a review of the literature to: (1) summarise the effect of obesity on the age-induced reduction in skeletal muscle contractile function; (2) understand whether obesity effects on skeletal muscle are similar in young and old muscle; (3) consider the consequences of these changes to whole-body functional performance; (4) outline important future work along with the potential for targeted intervention strategies to mitigate potential detrimental effects." @default.
• W3134631141 created "2021-03-15" @default.
• W3134631141 creator A5012517574 @default.
• W3134631141 creator A5033099453 @default.
• W3134631141 creator A5042024511 @default.
• W3134631141 creator A5079079348 @default.
• W3134631141 date "2021-03-02" @default.
• W3134631141 modified "2023-10-16" @default.
• W3134631141 title "Age-Related Skeletal Muscle Dysfunction Is Aggravated by Obesity: An Investigation of Contractile Function, Implications and Treatment" @default.
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