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• W3134645997 abstract "Parkinson’s disease (PD) is the most common movement disorder in the world, affecting 1–2 per 1,000 of the population. The main pathological changes of PD are damage of dopaminergic neurons in substantia nigra of the central nervous system and formation of Lewy bodies. These pathological changes also occur in the intestinal tract and are strongly associated with changes in intestinal flora. By reviewing the research progress in PD and its association with intestinal flora in recent years, this review expounded the mechanism of action between intestinal flora and PD as well as the transmission mode of α - synuclein in neurons. In clinical studies, β diversity of intestinal flora in PD patients was found to change significantly, with Lactobacillusaceae and Verrucomicrobiaceae being significantly increased and Lachnospiraceae and Prevotellaceae being significantly decreased. In addition, a longer PD course was associated with fewer bacteria and probiotics producing short chain fatty acids, but more pathogenic bacteria. Moreover, the motor symptoms of PD patients may be related to Enterobacteriaceae and bacteria. Most importantly, catechol-O-methyltransferase inhibitors and anticholinergic drugs could change the intestinal flora of PD patients and increase the harmful flora, whereas other anti-PD drugs such as levodopa, dopamine agonist, monoamine oxidase inhibitors, and amantadine did not have these effects. Probiotics, prebiotics, and synbiotics treatment had some potential values in improving the constipation of PD patients, promoting the growth of probiotics, and improving the level of intestinal inflammation. At present, there were only a few case studies and small sample studies which have found certain clinical efficacy of fecal microbiome transplants. Further studies are necessary to elaborate the relationship of PD with microbes." @default.
• W3134645997 created "2021-03-15" @default.
• W3134645997 creator A5003294780 @default.
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• W3134645997 creator A5054048970 @default.
• W3134645997 date "2021-03-08" @default.
• W3134645997 modified "2023-10-01" @default.
• W3134645997 title "Association of Parkinson’s Disease With Microbes and Microbiological Therapy" @default.
• W3134645997 cites W1903888485 @default.
• W3134645997 cites W1934236512 @default.
• W3134645997 cites W1965095016 @default.
• W3134645997 cites W1971756409 @default.
• W3134645997 cites W1985175917 @default.
• W3134645997 cites W1991772933 @default.
• W3134645997 cites W1995281235 @default.
• W3134645997 cites W1997858719 @default.
• W3134645997 cites W2012674659 @default.
• W3134645997 cites W2022499239 @default.
• W3134645997 cites W2031017582 @default.
• W3134645997 cites W2034825135 @default.
• W3134645997 cites W2044908785 @default.
• W3134645997 cites W2054107031 @default.
• W3134645997 cites W2055313665 @default.
• W3134645997 cites W2065236536 @default.
• W3134645997 cites W2066022004 @default.
• W3134645997 cites W2067773691 @default.
• W3134645997 cites W2073449985 @default.
• W3134645997 cites W2089607910 @default.
• W3134645997 cites W2089900719 @default.
• W3134645997 cites W2104306716 @default.
• W3134645997 cites W2105047187 @default.
• W3134645997 cites W2125879914 @default.
• W3134645997 cites W2133184469 @default.
• W3134645997 cites W2133938010 @default.
• W3134645997 cites W2136759951 @default.
• W3134645997 cites W2148140243 @default.
• W3134645997 cites W2149320847 @default.
• W3134645997 cites W2155058651 @default.
• W3134645997 cites W2155654820 @default.
• W3134645997 cites W2157102136 @default.
• W3134645997 cites W2167123129 @default.
• W3134645997 cites W2254642444 @default.
• W3134645997 cites W2291461558 @default.
• W3134645997 cites W2296954214 @default.
• W3134645997 cites W2329508959 @default.
• W3134645997 cites W2336585584 @default.
• W3134645997 cites W2346291302 @default.
• W3134645997 cites W2486618134 @default.
• W3134645997 cites W2509213166 @default.
• W3134645997 cites W2521622841 @default.
• W3134645997 cites W2523771096 @default.
• W3134645997 cites W2523905541 @default.
• W3134645997 cites W2528434724 @default.
• W3134645997 cites W2531051110 @default.
• W3134645997 cites W2558041282 @default.
• W3134645997 cites W2561721115 @default.
• W3134645997 cites W2584311212 @default.
• W3134645997 cites W2586298423 @default.
• W3134645997 cites W2587959748 @default.
• W3134645997 cites W2607019262 @default.
• W3134645997 cites W2608965099 @default.
• W3134645997 cites W2613763302 @default.
• W3134645997 cites W2615798278 @default.
• W3134645997 cites W2616539606 @default.
• W3134645997 cites W2617706731 @default.
• W3134645997 cites W2619485173 @default.
• W3134645997 cites W2626116524 @default.
• W3134645997 cites W2681281215 @default.
• W3134645997 cites W2745136677 @default.
• W3134645997 cites W2746380062 @default.
• W3134645997 cites W2746835184 @default.
• W3134645997 cites W2766355490 @default.
• W3134645997 cites W2767853360 @default.
• W3134645997 cites W2769629043 @default.
• W3134645997 cites W2781770958 @default.
• W3134645997 cites W2783610750 @default.
• W3134645997 cites W2790075460 @default.
• W3134645997 cites W2790781105 @default.
• W3134645997 cites W2790799100 @default.
• W3134645997 cites W2790863554 @default.
• W3134645997 cites W2791904618 @default.
• W3134645997 cites W2796430392 @default.
• W3134645997 cites W2802421303 @default.
• W3134645997 cites W2803911255 @default.
• W3134645997 cites W2806735213 @default.
• W3134645997 cites W2807153072 @default.
• W3134645997 cites W2884896164 @default.
• W3134645997 cites W2885763936 @default.
• W3134645997 cites W2887509155 @default.
• W3134645997 cites W2889234747 @default.
• W3134645997 cites W2894062910 @default.
• W3134645997 cites W2900346487 @default.
• W3134645997 cites W2906418973 @default.
• W3134645997 cites W2922746297 @default.
• W3134645997 cites W2945487772 @default.

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