Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134647298> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3134647298 abstract "Abstract Background : Breast cancer treatment-failure is related to low compliance rates, high costs, and long-term toxicities. Thus, it is necessary to find less toxic and cheaper treatments. The epimereandrostene-3beta,17alpha-diol (α-AED) has been proven to inhibit breast tumor cell proliferation in vitro , being an ideal candidate to treat mammary tumors. The aim of this study was to evaluate the in situ effects of α-AED on tumor mammary growth. 4T1 tumors with 14 days of growth were injected with an equivalent dose to the IC 50 (100 mM) and its double concentration (200 mM) of α-AED. Methods : The cell viability and cell proliferation of murine and human cancer cell lines after the treatment of α-AED were evaluated with sulforhodamine assay and bromodeoxyuridine incorporation, respectively. We also evaluated the size and tumor growth of the orthotopic tumor model after the treatment with α-AED. The tumor infiltration changes and cytokine determination into the tumor microenvironment were determined by flow cytometry and ELISA methods, respectively. The humoral response denoted by the production fo IgG anti-4T1 antibodies were also determined by ELISA methd. Results : Low and high concentrations of α-AED administrated intratumorally reduce the size and average tumor. α-AED also increased the percentages of NK, plasmatic and plasmablast cells in mice tumors injected with 100 mM of a-AED. Meanwhile, tumors injected with 200 mM of a-AED contained an elevated proportion of plasmablast and B cells. Of notice, VEGF levels in all a-AED-treated tumors were lower than the control and vehicle group. The tumor in situ response was reflected systemically by the increase of the anti-4T1 IgG in serum from a-AED-treated mice, but no other associated systemic changes were detected. The reduction in tumor size for to the local injection of a-AED is produced by the anti-proliferative effect of this hormone, that maybe associated to the VEGF reduction and metastasis. Conclusion : We observed an astonishing tumor size reduction and metastasis after the treatment with a-AED. The above suggest that a-AED can be used in clinical studies in order to prove its efficacy as an alternative of novel breast tumor treatment." @default.
- W3134647298 created "2021-03-15" @default.
- W3134647298 creator A5012018051 @default.
- W3134647298 creator A5020312094 @default.
- W3134647298 creator A5031981844 @default.
- W3134647298 creator A5056016674 @default.
- W3134647298 creator A5064586034 @default.
- W3134647298 creator A5068813646 @default.
- W3134647298 creator A5085272243 @default.
- W3134647298 date "2021-02-11" @default.
- W3134647298 modified "2023-10-18" @default.
- W3134647298 title "Novel Intratumoral Treatment With 5-Androstene-3b, 17a-Diol Inhibits Tumor Size and Metastasis In a Mice Model" @default.
- W3134647298 cites W1991845616 @default.
- W3134647298 cites W2027542963 @default.
- W3134647298 cites W2186351113 @default.
- W3134647298 cites W2904780259 @default.
- W3134647298 doi "https://doi.org/10.21203/rs.3.rs-179748/v1" @default.
- W3134647298 hasPublicationYear "2021" @default.
- W3134647298 type Work @default.
- W3134647298 sameAs 3134647298 @default.
- W3134647298 citedByCount "0" @default.
- W3134647298 crossrefType "posted-content" @default.
- W3134647298 hasAuthorship W3134647298A5012018051 @default.
- W3134647298 hasAuthorship W3134647298A5020312094 @default.
- W3134647298 hasAuthorship W3134647298A5031981844 @default.
- W3134647298 hasAuthorship W3134647298A5056016674 @default.
- W3134647298 hasAuthorship W3134647298A5064586034 @default.
- W3134647298 hasAuthorship W3134647298A5068813646 @default.
- W3134647298 hasAuthorship W3134647298A5085272243 @default.
- W3134647298 hasConcept C121608353 @default.
- W3134647298 hasConcept C126322002 @default.
- W3134647298 hasConcept C185592680 @default.
- W3134647298 hasConcept C203014093 @default.
- W3134647298 hasConcept C204232928 @default.
- W3134647298 hasConcept C2776107976 @default.
- W3134647298 hasConcept C2776187077 @default.
- W3134647298 hasConcept C2777701055 @default.
- W3134647298 hasConcept C2778260397 @default.
- W3134647298 hasConcept C2778690821 @default.
- W3134647298 hasConcept C2779013556 @default.
- W3134647298 hasConcept C2780394083 @default.
- W3134647298 hasConcept C3020616263 @default.
- W3134647298 hasConcept C502942594 @default.
- W3134647298 hasConcept C530470458 @default.
- W3134647298 hasConcept C553184892 @default.
- W3134647298 hasConcept C55493867 @default.
- W3134647298 hasConcept C62112901 @default.
- W3134647298 hasConcept C71924100 @default.
- W3134647298 hasConceptScore W3134647298C121608353 @default.
- W3134647298 hasConceptScore W3134647298C126322002 @default.
- W3134647298 hasConceptScore W3134647298C185592680 @default.
- W3134647298 hasConceptScore W3134647298C203014093 @default.
- W3134647298 hasConceptScore W3134647298C204232928 @default.
- W3134647298 hasConceptScore W3134647298C2776107976 @default.
- W3134647298 hasConceptScore W3134647298C2776187077 @default.
- W3134647298 hasConceptScore W3134647298C2777701055 @default.
- W3134647298 hasConceptScore W3134647298C2778260397 @default.
- W3134647298 hasConceptScore W3134647298C2778690821 @default.
- W3134647298 hasConceptScore W3134647298C2779013556 @default.
- W3134647298 hasConceptScore W3134647298C2780394083 @default.
- W3134647298 hasConceptScore W3134647298C3020616263 @default.
- W3134647298 hasConceptScore W3134647298C502942594 @default.
- W3134647298 hasConceptScore W3134647298C530470458 @default.
- W3134647298 hasConceptScore W3134647298C553184892 @default.
- W3134647298 hasConceptScore W3134647298C55493867 @default.
- W3134647298 hasConceptScore W3134647298C62112901 @default.
- W3134647298 hasConceptScore W3134647298C71924100 @default.
- W3134647298 hasLocation W31346472981 @default.
- W3134647298 hasOpenAccess W3134647298 @default.
- W3134647298 hasPrimaryLocation W31346472981 @default.
- W3134647298 hasRelatedWork W2060041427 @default.
- W3134647298 hasRelatedWork W2064431569 @default.
- W3134647298 hasRelatedWork W2129566023 @default.
- W3134647298 hasRelatedWork W2167685929 @default.
- W3134647298 hasRelatedWork W2358524972 @default.
- W3134647298 hasRelatedWork W2791088259 @default.
- W3134647298 hasRelatedWork W3180129935 @default.
- W3134647298 hasRelatedWork W4283771460 @default.
- W3134647298 hasRelatedWork W4311204730 @default.
- W3134647298 hasRelatedWork W4312075079 @default.
- W3134647298 isParatext "false" @default.
- W3134647298 isRetracted "false" @default.
- W3134647298 magId "3134647298" @default.
- W3134647298 workType "article" @default.