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• W3134670248 abstract "Organismic aging is known to be controlled by genetic and environmental traits. Pathways involved in the control of cellular metabolism play a crucial role. Previously, we identified a role of PaCLPP, a mitochondrial matrix protease, in the control of the mitochondrial energy metabolism, aging, and lifespan of the fungal aging model Podospora anserina . Most surprisingly, we made the counterintuitive observation that the ablation of this component of the mitochondrial quality control network leads to lifespan extension. In the current study, we investigated the role of energy metabolism of P. anserina . An age-dependent metabolome analysis of the wild type and a PaClpP deletion strain verified differences and changes of various metabolites in cultures of the PaClpP mutant and the wild type. Based on these data, we generated and analyzed a PaSnf1 deletion mutant and a Δ PaSnf1 /Δ PaClpP double mutant. In both mutants PaSNF1, the catalytic α-subunit of AMP-activated protein kinase (AMPK) is ablated. PaSNF1 was found to be required for the development of fruiting bodies and ascospores and the progeny of sexual reproduction of this ascomycete and impact mitochondrial dynamics and autophagy. Most interestingly, while the single PaSnf1 deletion mutant is characterized by a slight lifespan increase, simultaneous deletion of PaSnf1 and PaClpP leads to a pronounced lifespan extension. This synergistic effect is strongly reinforced in the presence of the mating-type “minus”-linked allele of the rmp1 gene. Compared to the wild type, culture temperature of 35°C instead of the standard laboratory temperature of 27°C leads to a short-lived phenotype of the Δ PaSnf1 /Δ PaClpP double mutant. Overall, our study provides novel evidence for complex interactions of different molecular pathways involved in mitochondrial quality control, gene expression, and energy metabolism in the control of organismic aging." @default.
• W3134670248 created "2021-03-15" @default.
• W3134670248 creator A5028586153 @default.
• W3134670248 creator A5040508026 @default.
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• W3134670248 date "2021-03-04" @default.
• W3134670248 modified "2023-10-12" @default.
• W3134670248 title "Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension" @default.
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• W3134670248 doi "https://doi.org/10.3389/fcell.2021.616520" @default.
• W3134670248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7969656" @default.
• W3134670248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33748105" @default.
• W3134670248 hasPublicationYear "2021" @default.
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