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• W3134672313 abstract "Abstract Background Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of crucial epigenetic regulatory molecules, has been under explored in skeletal biology. Results Here we report a young patient with short stature, hypothalamic dysfunction and mild macrocephaly, who carries a maternally inherited 690 kb deletion at Chr.1q24.2 encompassing a noncoding RNA gene, DNM3OS , embedded on the opposite strand in an intron of the DYNAMIN 3 ( DNM3) gene. We show that lncRNA DNM3OS sustains the proliferation of chondrocytes independent of two co-cistronic microRNAs miR-199a and miR-214 . We further show that nerve growth factor ( NGF ), a known factor of chondrocyte growth, is a key target of DNM3OS -mediated control of chondrocyte proliferation. Conclusions This work demonstrates that DNM3OS is essential for preventing premature differentiation of chondrocytes required for bone growth through endochondral ossification." @default.
• W3134672313 created "2021-03-15" @default.
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• W3134672313 date "2021-03-02" @default.
• W3134672313 modified "2023-10-16" @default.
• W3134672313 title "Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development" @default.
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• W3134672313 doi "https://doi.org/10.1186/s13578-021-00559-8" @default.
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