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• W3134711152 endingPage "e0245410" @default.
• W3134711152 startingPage "e0245410" @default.
• W3134711152 abstract "The present study presents a non-surgical approach to assess colonic mechanical sensitivity in mice using colonometry, a technique in which colonic stretch-reflex contractions are measured by recording intracolonic pressures during saline infusion into the distal colon in a constant rate. Colonometrical recording has been used to assess colonic function in healthy individuals and patients with neurological disorders. Here we found that colonometry can also be implemented in mice, with an optimal saline infusion rate of 1.2 mL/h. Colonometrograms showed intermittent pressure rises that was caused by periodical colonic contractions. In the sceneries of colonic hypersensitivity that was generated post 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colonic inflammation, following chemogenetic activation of primary afferent neurons, or immediately after noxious stimulation of the colon by colorectal distension (CRD), the amplitude of intracolonic pressure (A ICP ) was markedly elevated which was accompanied by a faster pressure rising (ΔP/Δt). Colonic hypersensitivity-associated A ICP elevation was a result of the enhanced strength of colonic stretch-reflex contraction which reflected the heightened activity of the colonic sensory reflex pathways. The increased value of ΔP/Δt in colonic hypersensitivity indicated a lower threshold of colonic mechanical sensation by which colonic stretch-reflex contraction was elicited by a smaller saline infusion volume during a shorter period of infusion time. Chemogenetic inhibition of primary afferent pathway that was governed by Nav1.8-expressing cells attenuated TNBS-induced up-regulations of A ICP , ΔP/Δt, and colonic pain behavior in response to CRD. These findings support that colonometrograms can be used for analysis of colonic pain in mice." @default.
• W3134711152 created "2021-03-15" @default.
• W3134711152 creator A5062970963 @default.
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• W3134711152 date "2021-03-12" @default.
• W3134711152 modified "2023-09-24" @default.
• W3134711152 title "An objective approach to assess colonic pain in mice using colonometry" @default.
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• W3134711152 doi "https://doi.org/10.1371/journal.pone.0245410" @default.
• W3134711152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7954293" @default.
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• W3134711152 hasPublicationYear "2021" @default.
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