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• W3134711195 abstract "The advent of first and second-generation immune checkpoint blockade (ICI) has resulted in improved survival of patients with metastatic melanoma over the past decade. However, the majority of patients ultimately progress despite these treatments, which has served as an impetus to consider a range of subsequent therapies. Many of the next generation of immunotherapeutic agents focus on modifying the immune system to overcome resistance to checkpoint blockade. ICI resistance can be understood as primary, or acquired—where the latter is the most common scenario. While there are several postulated mechanisms by which resistance, particularly acquired resistance, occurs, the predominant escape mechanisms include T cell exhaustion, upregulation of alternative inhibitory checkpoint receptors, and alteration of the tumor microenvironment (TME) into a more suppressive, anti-inflammatory state. Therapeutic agents in development are designed to work by combating one or more of these resistance mechanisms. These strategies face the added challenge of minimizing immune-related toxicities, while improving antitumor efficacy. This review focuses upon the following categories of novel therapeutics: 1) alternative inhibitory receptor pathways; 2) damage- or pathogen-associated molecular patterns (DAMPs/PAMPs); and 3) immune cell signaling mediators. We present the current state of these therapies, including preclinical and clinical data available for these targets under development." @default.
• W3134711195 created "2021-03-15" @default.
• W3134711195 creator A5007239425 @default.
• W3134711195 creator A5026494264 @default.
• W3134711195 date "2021-03-01" @default.
• W3134711195 modified "2023-10-01" @default.
• W3134711195 title "Beyond PD-1: The Next Frontier for Immunotherapy in Melanoma" @default.
• W3134711195 cites W1517571912 @default.
• W3134711195 cites W1791160312 @default.
• W3134711195 cites W1856206988 @default.
• W3134711195 cites W1944300754 @default.
• W3134711195 cites W1975915404 @default.
• W3134711195 cites W1982061062 @default.
• W3134711195 cites W1987625640 @default.
• W3134711195 cites W1988105476 @default.
• W3134711195 cites W1988474688 @default.
• W3134711195 cites W1992315309 @default.
• W3134711195 cites W2009755744 @default.
• W3134711195 cites W2013177587 @default.
• W3134711195 cites W2016163671 @default.
• W3134711195 cites W2019035934 @default.
• W3134711195 cites W2025459290 @default.
• W3134711195 cites W2029399624 @default.
• W3134711195 cites W2034028219 @default.
• W3134711195 cites W2038612629 @default.
• W3134711195 cites W2048657818 @default.
• W3134711195 cites W2059453959 @default.
• W3134711195 cites W2060004514 @default.
• W3134711195 cites W2068487611 @default.
• W3134711195 cites W2070631889 @default.
• W3134711195 cites W2078731019 @default.
• W3134711195 cites W2092830781 @default.
• W3134711195 cites W2095406487 @default.
• W3134711195 cites W2095808484 @default.
• W3134711195 cites W2097288420 @default.
• W3134711195 cites W2100510996 @default.
• W3134711195 cites W2101477183 @default.
• W3134711195 cites W2103277177 @default.
• W3134711195 cites W2108565475 @default.
• W3134711195 cites W2109274792 @default.
• W3134711195 cites W2115686439 @default.
• W3134711195 cites W2119080021 @default.
• W3134711195 cites W2121273824 @default.
• W3134711195 cites W2121810724 @default.
• W3134711195 cites W2123914905 @default.
• W3134711195 cites W2144201925 @default.
• W3134711195 cites W2145476394 @default.
• W3134711195 cites W2149121521 @default.
• W3134711195 cites W2151293773 @default.
• W3134711195 cites W2154983077 @default.
• W3134711195 cites W2159022177 @default.
• W3134711195 cites W2162856391 @default.
• W3134711195 cites W2166662937 @default.
• W3134711195 cites W2166932124 @default.
• W3134711195 cites W2167188058 @default.
• W3134711195 cites W2168530155 @default.
• W3134711195 cites W2344221521 @default.
• W3134711195 cites W2469758901 @default.
• W3134711195 cites W2518912365 @default.
• W3134711195 cites W2548633484 @default.
• W3134711195 cites W2572174216 @default.
• W3134711195 cites W2591674407 @default.
• W3134711195 cites W2592935721 @default.
• W3134711195 cites W2593059553 @default.
• W3134711195 cites W2593111137 @default.
• W3134711195 cites W2617823945 @default.
• W3134711195 cites W2655262992 @default.
• W3134711195 cites W2744377419 @default.
• W3134711195 cites W2763833329 @default.
• W3134711195 cites W2772077761 @default.
• W3134711195 cites W2773920738 @default.
• W3134711195 cites W2775080684 @default.
• W3134711195 cites W2782007611 @default.
• W3134711195 cites W2789362784 @default.
• W3134711195 cites W2792883957 @default.
• W3134711195 cites W2795455773 @default.
• W3134711195 cites W2804102248 @default.
• W3134711195 cites W2807864393 @default.
• W3134711195 cites W2888060359 @default.
• W3134711195 cites W2888914203 @default.
• W3134711195 cites W2890454711 @default.
• W3134711195 cites W2894313087 @default.
• W3134711195 cites W2896600825 @default.
• W3134711195 cites W2898194176 @default.
• W3134711195 cites W2898497938 @default.
• W3134711195 cites W2901171191 @default.
• W3134711195 cites W2902968854 @default.
• W3134711195 cites W2914335731 @default.
• W3134711195 cites W2944255077 @default.
• W3134711195 cites W2947938389 @default.
• W3134711195 cites W2949375297 @default.
• W3134711195 cites W2951756816 @default.
• W3134711195 cites W2953773959 @default.
• W3134711195 cites W2959586017 @default.
• W3134711195 cites W2964256876 @default.
• W3134711195 cites W2977049114 @default.
• W3134711195 cites W2978508420 @default.
• W3134711195 cites W3015627396 @default.
• W3134711195 cites W3028354168 @default.
• W3134711195 cites W3031115858 @default.

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