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- W3134712462 endingPage "344" @default.
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- W3134712462 abstract "Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK inhibitors (CKIs), currently comprising the CDK-interacting protein/kinase inhibitory protein (CIP/KIP) family and the inhibitor of kinase (INK) family. Recent studies have identified a third group of CKIs, called ribosomal protein-inhibiting CDKs (RPICs). RPICs were discovered in the context of cellular senescence, a stable cell cycle arrest with tumor-suppressing abilities. RPICs accumulate in the nonribosomal fraction of senescent cells due to a decrease in rRNA biogenesis. Accordingly, RPICs are often downregulated in human cancers together with other ribosomal proteins, the tumor-suppressor functions of which are still under study. In this review, we discuss unique therapies that have been developed to target CDK activity in the context of cancer treatment or senescence-associated pathologies, providing novel tools for precision medicine." @default.
- W3134712462 created "2021-03-15" @default.
- W3134712462 creator A5010665476 @default.
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- W3134712462 creator A5062908234 @default.
- W3134712462 creator A5067092778 @default.
- W3134712462 creator A5084890700 @default.
- W3134712462 date "2021-05-01" @default.
- W3134712462 modified "2023-10-16" @default.
- W3134712462 title "New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy" @default.
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