FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134718002> ?p ?o ?g. }

• W3134718002 endingPage "676" @default.
• W3134718002 startingPage "661" @default.
• W3134718002 abstract "Ulcerative Colitis (UC) is a chronic inflammation disease, and the incidence of UC is increasing recently. Both clinical trials and animal experiments show that moxibustion is a complementary and alternative treatment for UC. Previous studies showed that moxibustion can improve UC by regulating the balance of Tregs and Th17 (Sun et al., 2017). Treg cells is one subset of CD4[Formula: see text] T cells that exert the immunosuppressive function. CD39 and CD73, expressed on the surface of Tregs, hydrolyze ATP to AMP and are further involved in the immunosuppressive function of Tregs. In this study, we investigated the effect of moxibustion on CD39[Formula: see text] Tregs and CD73[Formula: see text] Tregs in dextran sulfate sodium (DSS) induced UC mice. The A2a receptor (A2aR), one of the targets of adenosine, was also detected. The results showed that moxibustion could increase the expression of CD39, CD73, and A2aR in colonic tissue and improve the proportion of CD39[Formula: see text] Tregs and CD73[Formula: see text] Tregs in peripheral blood, inguinal draining lymph nodes and spleen in the UC model. Additionally, A2aR agonists enhanced the cell viability of colonic epithelial cells and inhibit the production of cytokines IL-6 and TNF-[Formula: see text] in vitro, which may further influence the pathway of ATP purine signal metabolism and alleviates the gut inflammation of UC mice. Taken together, this study provides supplemental evidence to reveal the immune related mechanism of moxibustion in the treatment of UC." @default.
• W3134718002 created "2021-03-15" @default.
• W3134718002 creator A5006615211 @default.
• W3134718002 creator A5028490219 @default.
• W3134718002 creator A5042481169 @default.
• W3134718002 creator A5048946343 @default.
• W3134718002 creator A5062329459 @default.
• W3134718002 creator A5062796567 @default.
• W3134718002 creator A5069466795 @default.
• W3134718002 creator A5090929810 @default.
• W3134718002 date "2021-01-01" @default.
• W3134718002 modified "2023-10-18" @default.
• W3134718002 title "CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis" @default.
• W3134718002 cites W1513558382 @default.
• W3134718002 cites W1969302884 @default.
• W3134718002 cites W2004115431 @default.
• W3134718002 cites W2010181302 @default.
• W3134718002 cites W2014127183 @default.
• W3134718002 cites W2029030766 @default.
• W3134718002 cites W2049136547 @default.
• W3134718002 cites W2086556660 @default.
• W3134718002 cites W2094637914 @default.
• W3134718002 cites W2104167689 @default.
• W3134718002 cites W2123784937 @default.
• W3134718002 cites W2138584845 @default.
• W3134718002 cites W2158614641 @default.
• W3134718002 cites W2324121885 @default.
• W3134718002 cites W2413587463 @default.
• W3134718002 cites W2469055654 @default.
• W3134718002 cites W2512624221 @default.
• W3134718002 cites W2605265747 @default.
• W3134718002 cites W2726260118 @default.
• W3134718002 cites W2767631063 @default.
• W3134718002 cites W2775340300 @default.
• W3134718002 cites W2791921463 @default.
• W3134718002 cites W2793792937 @default.
• W3134718002 cites W2795182374 @default.
• W3134718002 cites W2883544426 @default.
• W3134718002 cites W2901628691 @default.
• W3134718002 cites W2902066950 @default.
• W3134718002 cites W2906727442 @default.
• W3134718002 cites W2936769587 @default.
• W3134718002 cites W3009012426 @default.
• W3134718002 cites W3024703728 @default.
• W3134718002 cites W4210972027 @default.
• W3134718002 cites W4211018795 @default.
• W3134718002 doi "https://doi.org/10.1142/s0192415x21500300" @default.
• W3134718002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33683190" @default.
• W3134718002 hasPublicationYear "2021" @default.
• W3134718002 type Work @default.
• W3134718002 sameAs 3134718002 @default.
• W3134718002 citedByCount "9" @default.
• W3134718002 countsByYear W31347180022022 @default.
• W3134718002 countsByYear W31347180022023 @default.
• W3134718002 crossrefType "journal-article" @default.
• W3134718002 hasAuthorship W3134718002A5006615211 @default.
• W3134718002 hasAuthorship W3134718002A5028490219 @default.
• W3134718002 hasAuthorship W3134718002A5042481169 @default.
• W3134718002 hasAuthorship W3134718002A5048946343 @default.
• W3134718002 hasAuthorship W3134718002A5062329459 @default.
• W3134718002 hasAuthorship W3134718002A5062796567 @default.
• W3134718002 hasAuthorship W3134718002A5069466795 @default.
• W3134718002 hasAuthorship W3134718002A5090929810 @default.
• W3134718002 hasConcept C126322002 @default.
• W3134718002 hasConcept C142724271 @default.
• W3134718002 hasConcept C187316574 @default.
• W3134718002 hasConcept C203014093 @default.
• W3134718002 hasConcept C204787440 @default.
• W3134718002 hasConcept C2775862500 @default.
• W3134718002 hasConcept C2776090121 @default.
• W3134718002 hasConcept C2776914184 @default.
• W3134718002 hasConcept C2776991684 @default.
• W3134718002 hasConcept C2777674692 @default.
• W3134718002 hasConcept C2778260677 @default.
• W3134718002 hasConcept C2778296632 @default.
• W3134718002 hasConcept C2779134260 @default.
• W3134718002 hasConcept C2780479503 @default.
• W3134718002 hasConcept C56837625 @default.
• W3134718002 hasConcept C71924100 @default.
• W3134718002 hasConcept C79484868 @default.
• W3134718002 hasConcept C8891405 @default.
• W3134718002 hasConcept C98274493 @default.
• W3134718002 hasConceptScore W3134718002C126322002 @default.
• W3134718002 hasConceptScore W3134718002C142724271 @default.
• W3134718002 hasConceptScore W3134718002C187316574 @default.
• W3134718002 hasConceptScore W3134718002C203014093 @default.
• W3134718002 hasConceptScore W3134718002C204787440 @default.
• W3134718002 hasConceptScore W3134718002C2775862500 @default.
• W3134718002 hasConceptScore W3134718002C2776090121 @default.
• W3134718002 hasConceptScore W3134718002C2776914184 @default.
• W3134718002 hasConceptScore W3134718002C2776991684 @default.
• W3134718002 hasConceptScore W3134718002C2777674692 @default.
• W3134718002 hasConceptScore W3134718002C2778260677 @default.
• W3134718002 hasConceptScore W3134718002C2778296632 @default.
• W3134718002 hasConceptScore W3134718002C2779134260 @default.
• W3134718002 hasConceptScore W3134718002C2780479503 @default.
• W3134718002 hasConceptScore W3134718002C56837625 @default.
• W3134718002 hasConceptScore W3134718002C71924100 @default.

• next