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- W3134718897 endingPage "166912" @default.
- W3134718897 startingPage "166912" @default.
- W3134718897 abstract "The highly conserved C-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises a consensus heptad (Y1S2P3T4S5P6S7) repeated multiple times. Despite the simplicity of its sequence, the essential CTD domain orchestrates eukaryotic transcription and co-transcriptional processes, including transcription initiation, elongation, and termination, and mRNA processing. These distinct facets of the transcription cycle rely on specific post-translational modifications (PTM) of the CTD, in which five out of the seven residues in the heptad repeat are subject to phosphorylation. A hypothesis termed the “CTD code” has been proposed in which these PTMs and their combinations generate a sophisticated landscape for spatiotemporal recruitment of transcription regulators to Pol II. In this review, we summarize the recent experimental evidence understanding the biological role of the CTD, implicating a context-dependent theme that significantly enhances the ability of accurate transcription by RNA polymerase II. Furthermore, feedback communication between the CTD and histone modifications coordinates chromatin states with RNA polymerase II-mediated transcription, ensuring the effective and accurate conversion of information into cellular responses." @default.
- W3134718897 created "2021-03-15" @default.
- W3134718897 creator A5025572710 @default.
- W3134718897 creator A5060744228 @default.
- W3134718897 creator A5063336135 @default.
- W3134718897 creator A5086664284 @default.
- W3134718897 date "2021-07-01" @default.
- W3134718897 modified "2023-10-14" @default.
- W3134718897 title "Simplicity is the Ultimate Sophistication—Crosstalk of Post-translational Modifications on the RNA Polymerase II" @default.
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