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- W3134723738 endingPage "113660" @default.
- W3134723738 startingPage "113660" @default.
- W3134723738 abstract "Spinal cord injury (SCI) can cause chronic paralysis and incontinence and remains a major worldwide healthcare burden, with no regenerative treatment clinically available. Intraspinal transplantation of olfactory ensheathing cells (OECs) and injection of chondroitinase ABC (chABC) are both promising therapies but limited and unpredictable responses are seen, particularly in canine clinical trials. Sustained delivery of chABC presents a challenge due to its thermal instability; we hypothesised that transplantation of canine olfactory mucosal OECs genetically modified ex vivo by lentiviral transduction to express chABC (cOEC-chABC) would provide novel delivery of chABC and synergistic therapy. Rats were randomly divided into cOEC-chABC, cOEC, or vehicle transplanted groups and received transplant immediately after dorsal column crush corticospinal tract (CST) injury. Rehabilitation for forepaw reaching and blinded behavioural testing was conducted for 8 weeks. We show that cOEC-chABC transplanted animals recover greater forepaw reaching accuracy on Whishaw testing and more normal gait than cOEC transplanted or vehicle control rats. Increased CST axon sprouting cranial to the injury and serotonergic fibres caudal to the injury suggest a mechanism for recovery. We therefore demonstrate that cOECs can deliver sufficient chABC to drive modest functional improvement, and that this genetically engineered cellular and molecular approach is a feasible combination therapy for SCI." @default.
- W3134723738 created "2021-03-15" @default.
- W3134723738 creator A5012358525 @default.
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- W3134723738 creator A5075727596 @default.
- W3134723738 date "2021-06-01" @default.
- W3134723738 modified "2023-09-28" @default.
- W3134723738 title "Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury" @default.
- W3134723738 cites W1539945441 @default.
- W3134723738 cites W1657897383 @default.
- W3134723738 cites W1843688890 @default.
- W3134723738 cites W1926921372 @default.
- W3134723738 cites W1967109943 @default.
- W3134723738 cites W1968062801 @default.
- W3134723738 cites W1974257111 @default.
- W3134723738 cites W1975137870 @default.
- W3134723738 cites W1975322262 @default.
- W3134723738 cites W1975957256 @default.
- W3134723738 cites W1977523545 @default.
- W3134723738 cites W1978772420 @default.
- W3134723738 cites W1979447754 @default.
- W3134723738 cites W1981638828 @default.
- W3134723738 cites W1983891257 @default.
- W3134723738 cites W1985297297 @default.
- W3134723738 cites W1988657611 @default.
- W3134723738 cites W1990277219 @default.
- W3134723738 cites W1990815396 @default.
- W3134723738 cites W1992292158 @default.
- W3134723738 cites W1992301107 @default.
- W3134723738 cites W1998483724 @default.
- W3134723738 cites W1999941576 @default.
- W3134723738 cites W2001882876 @default.
- W3134723738 cites W2006875006 @default.
- W3134723738 cites W2007056701 @default.
- W3134723738 cites W2010771423 @default.
- W3134723738 cites W2012558043 @default.
- W3134723738 cites W2012694416 @default.
- W3134723738 cites W2012924135 @default.
- W3134723738 cites W2012928251 @default.
- W3134723738 cites W2013473091 @default.
- W3134723738 cites W2017343522 @default.
- W3134723738 cites W2024317850 @default.
- W3134723738 cites W2025416757 @default.
- W3134723738 cites W2027013540 @default.
- W3134723738 cites W2028717305 @default.
- W3134723738 cites W2029527028 @default.
- W3134723738 cites W2030093915 @default.
- W3134723738 cites W2030927825 @default.
- W3134723738 cites W2033869466 @default.
- W3134723738 cites W2034997186 @default.
- W3134723738 cites W2038881167 @default.
- W3134723738 cites W2047730770 @default.
- W3134723738 cites W2052380760 @default.
- W3134723738 cites W2052561315 @default.
- W3134723738 cites W2054548538 @default.
- W3134723738 cites W2055205487 @default.
- W3134723738 cites W2059493571 @default.
- W3134723738 cites W2059653271 @default.
- W3134723738 cites W2061348706 @default.
- W3134723738 cites W2061473541 @default.
- W3134723738 cites W2065723600 @default.
- W3134723738 cites W2066487839 @default.
- W3134723738 cites W2071526203 @default.
- W3134723738 cites W2074439158 @default.
- W3134723738 cites W2075741564 @default.
- W3134723738 cites W2081116197 @default.
- W3134723738 cites W2082883399 @default.
- W3134723738 cites W2082895563 @default.
- W3134723738 cites W2084357882 @default.
- W3134723738 cites W2088462474 @default.
- W3134723738 cites W2092633851 @default.
- W3134723738 cites W2094308504 @default.
- W3134723738 cites W2096020680 @default.
- W3134723738 cites W2099134671 @default.
- W3134723738 cites W2100075263 @default.
- W3134723738 cites W2100615567 @default.
- W3134723738 cites W2101996466 @default.
- W3134723738 cites W2102366389 @default.
- W3134723738 cites W2103302443 @default.
- W3134723738 cites W2104968232 @default.
- W3134723738 cites W2106069972 @default.
- W3134723738 cites W2108324820 @default.
- W3134723738 cites W2115533079 @default.
- W3134723738 cites W2115761515 @default.
- W3134723738 cites W2118427313 @default.
- W3134723738 cites W2124428807 @default.
- W3134723738 cites W2125133570 @default.
- W3134723738 cites W2144623814 @default.
- W3134723738 cites W2148336088 @default.
- W3134723738 cites W2167208176 @default.
- W3134723738 cites W2167279371 @default.
- W3134723738 cites W2218149366 @default.
- W3134723738 cites W2291269974 @default.
- W3134723738 cites W2413947359 @default.