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• W3134724235 endingPage "104839" @default.
• W3134724235 startingPage "104839" @default.
• W3134724235 abstract "Antimicrobial peptides (AMPs) are presently being revisited as promising potential antimicrobial combat agents. Acquisition of resistance to AMPs is very rare compared to conventional antibiotics as they kill microbes by direct disruption of cellular components including the microbial membrane and DNA. In this study four sources of mammalian plasma (human, bovine, caprine and ovine) were explored for presence and effectiveness of antimicrobial peptides by the spot-on–lawn method, followed by the agar well diffusion assay to confirm their antibacterial activity. This was followed by determination of their minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) by the broth macrodilusion method. The MICs were compared to those produced by the antibiotics Ampicillin, Amoxicillin, Doxycycline and Metronidazole. All four plasma types exhibited antibacterial activity in their native form (plasmaN) or in presence of added pepsin (plasmap). The highest antibacterial activity was shown by ovine plasmap against Klebsiella pneumoniae (MIC at dilution of 1:128), while least activity (MIC at dilution of 1:2) was shown by bovine plasmap and ovine plasmaN against K. pneumoniae, ovine plasmaN against E. coli, and ovine plasmap against Staph. aureus. All plasma sources achieved bactericidal effect. Activity of ovine plasmaN against K. pneumoniae was higher than that due to Ampilcillin, Amoxicillin, Doxycycline or Metronidazole. The least antibacterial activity was achieved by Ampicillin against K. pneumoniae, E. coli and Bacillus subtilis. Metronidazole had no effect on any of the four bacteria tested. These results indicate that AMPs hold great promise as a valuable renewed tool in the control of pathogenic microbes." @default.
• W3134724235 created "2021-03-15" @default.
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• W3134724235 date "2021-07-01" @default.
• W3134724235 modified "2023-10-01" @default.
• W3134724235 title "Exploratory investigation on the antibacterial effect of antimicrobial peptides of four mammalian plasmas" @default.
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• W3134724235 doi "https://doi.org/10.1016/j.micpath.2021.104839" @default.
• W3134724235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33689814" @default.
• W3134724235 hasPublicationYear "2021" @default.
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