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- W3134729907 endingPage "612" @default.
- W3134729907 startingPage "598" @default.
- W3134729907 abstract "Organelles cooperate with each other to control cellular homeostasis and cell functions by forming close connections through membrane contact sites. Important contacts are present between the endoplasmic reticulum (ER), the main intracellular Ca2+-storage organelle, and the mitochondria, the organelle responsible not only for the majority of cellular ATP production but also for switching on cell death processes. Several Ca2+-transport systems focalize at these contact sites, thereby enabling the efficient transmission of Ca2+ signals from the ER toward mitochondria. This provides tight control of mitochondrial functions at the microdomain level. Here, we discuss how ER-mitochondrial Ca2+ transfers support cell function and how their dysregulation underlies, drives, or contributes to pathogenesis and pathophysiology, with a major focus on cancer and neurodegeneration but also with attention to other diseases such as diabetes and rare genetic diseases." @default.
- W3134729907 created "2021-03-15" @default.
- W3134729907 creator A5019565239 @default.
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- W3134729907 creator A5049890385 @default.
- W3134729907 creator A5074668880 @default.
- W3134729907 creator A5084581276 @default.
- W3134729907 date "2021-07-01" @default.
- W3134729907 modified "2023-10-14" @default.
- W3134729907 title "Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease" @default.
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