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- W3134737464 abstract "To develop a suitable and effective vaccine against Staphylococcus aureus (S. aureus), we selected the Hla-MntCSACOL0723 (HMS) recombinant protein with two different formulations of alum and Monophosphoryl lipid A (MPL) adjuvants. In this study, we aimed to evaluate the potentials of alum and MPL adjuvants in stimulating the immune response of HMS vaccine candidate against S. aureus. In order to evaluate the type of induced immune response, anti-HMS total IgG, IgG1, IgG2a, and IFN-γ, IL-2, IL-4 and IL-17 cytokines were determined after vaccination of mice with alum-HMS, MPL-HMS candidates. Mice were challenged with Methicillin-resistant Staphylococcus aureus (MRSA) was isolated from pressure sores and evaluated for bacterial load in the kidney homogenates and survival rate. It was observed that total IgG and isotypes (IgG1 and IgG2a), IL-4 and IL-17 were significantly increased in the group received alum-HMS vaccine compared with the group received MPL-HMS formulation. In other hand, the levels of IFN- γ and IL-2 cytokines in the group received MPL-HMS was higher than group received alum- HMS formulation. Bacterial load in the mice received HMS protein formulated with alum adjuvant was reduced more than the mice received HMS protein formulated with MPL adjuvant. Histopathological analysis showed more pathological changes in kidney tissues of group received of MPL-HMS compared with alum-HMS formulation.The survival rate was equal in both groups of immunized with alum-HMS and MPL-HMS formulations. Finally, it could be concluded that both adjuvants of alum and MPL are suitable immune response enhancers to HMS vaccine candidate." @default.
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- W3134737464 date "2021-01-01" @default.
- W3134737464 modified "2023-09-24" @default.
- W3134737464 title "Effective Protection by Adjuvant Formulated Hla-MntC-SACOL0723 Fusion Protein in a Mouse Model of Staphylococcus aureus Systemic Infection" @default.
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