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- W3134744679 abstract "Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork directionality profiles obtained by RNA-seq, Repli-seq, and OK-seq. Both, the origin recognition complex (ORC) and the minichromosome maintenance complex (MCM) are significantly and homogeneously depleted from transcribed genes, enriched at gene promoters, and more abundant in early- than in late-replicating domains. Surprisingly, after controlling these variables, no difference in ORC/MCM density is detected between initiation zones, termination zones, unidirectionally replicating regions, and randomly replicating regions. Therefore, ORC/MCM density correlates with replication timing but does not solely regulate the probability of replication initiation. Interestingly, H4K20me3, a histone modification proposed to facilitate late origin licensing, was enriched in late-replicating initiation zones and gene deserts of stochastic replication fork direction. We discuss potential mechanisms specifying when and where replication initiates in human cells." @default.
- W3134744679 created "2021-03-15" @default.
- W3134744679 creator A5007655086 @default.
- W3134744679 creator A5012760420 @default.
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- W3134744679 creator A5036869657 @default.
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- W3134744679 creator A5060703246 @default.
- W3134744679 creator A5065576952 @default.
- W3134744679 creator A5069430515 @default.
- W3134744679 creator A5090277402 @default.
- W3134744679 date "2021-03-08" @default.
- W3134744679 modified "2023-10-14" @default.
- W3134744679 title "Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones" @default.
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