Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134747341> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3134747341 abstract "Acute systemic hypoxia (Hx) increases leukocyte adherence and vascular permeability in post-capillary venules of rats. When animals are chronically hypoxic, the initial microvascular inflammation resolves in part due to upregulation of inducible nitric oxide synthase (iNOS). Inhibition of prolyl hydroxylase (PHD) has been shown to increase hypoxia-inducible factor-1 (HIF-1) levels, which can increase iNOS expression. Objective This study evaluated whether inhibition of PHD attenuated Hx-induced increased vascular permeability, and if upregulation of iNOS was involved. Methods Hx was produced by a reduction in inspired O2 from 21% to 10%. Intravital microscopy was used to measure vascular permeability in mesenteric venules of anesthetized rats. The PHD inhibitor EDHB was administered to rats 24 hrs prior to experiments. Results Hx increased vascular permeability markedly in vehicle-treated rats but significantly less in EDHB-treated rats. Superfusion of the mesentery with the iNOS inhibitor L-NIL caused a significant increase in vascular permeability during Hx in EDHB- but not vehicle-treated rats. Conclusion These results show that inhibition of PHD reduces Hx-induced hyperpermeability in part through iNOS upregulation, and are consistent with a HIF-1-dependent mechanism." @default.
- W3134747341 created "2021-03-15" @default.
- W3134747341 creator A5027215902 @default.
- W3134747341 creator A5027857685 @default.
- W3134747341 creator A5043648826 @default.
- W3134747341 creator A5054663579 @default.
- W3134747341 creator A5072459480 @default.
- W3134747341 date "2010-04-01" @default.
- W3134747341 modified "2023-10-14" @default.
- W3134747341 title "Prolyl hydroxylase inhibition attenuates hypoxia‐induced hyperpermeability via iNOS upregulation" @default.
- W3134747341 doi "https://doi.org/10.1096/fasebj.24.1_supplement.975.10" @default.
- W3134747341 hasPublicationYear "2010" @default.
- W3134747341 type Work @default.
- W3134747341 sameAs 3134747341 @default.
- W3134747341 citedByCount "0" @default.
- W3134747341 crossrefType "journal-article" @default.
- W3134747341 hasAuthorship W3134747341A5027215902 @default.
- W3134747341 hasAuthorship W3134747341A5027857685 @default.
- W3134747341 hasAuthorship W3134747341A5043648826 @default.
- W3134747341 hasAuthorship W3134747341A5054663579 @default.
- W3134747341 hasAuthorship W3134747341A5072459480 @default.
- W3134747341 hasConcept C104317684 @default.
- W3134747341 hasConcept C113045295 @default.
- W3134747341 hasConcept C126322002 @default.
- W3134747341 hasConcept C12722491 @default.
- W3134747341 hasConcept C127561419 @default.
- W3134747341 hasConcept C134018914 @default.
- W3134747341 hasConcept C178790620 @default.
- W3134747341 hasConcept C185592680 @default.
- W3134747341 hasConcept C2776914184 @default.
- W3134747341 hasConcept C2777622882 @default.
- W3134747341 hasConcept C2859252 @default.
- W3134747341 hasConcept C519581460 @default.
- W3134747341 hasConcept C540031477 @default.
- W3134747341 hasConcept C55493867 @default.
- W3134747341 hasConcept C71924100 @default.
- W3134747341 hasConcept C7836513 @default.
- W3134747341 hasConcept C98274493 @default.
- W3134747341 hasConceptScore W3134747341C104317684 @default.
- W3134747341 hasConceptScore W3134747341C113045295 @default.
- W3134747341 hasConceptScore W3134747341C126322002 @default.
- W3134747341 hasConceptScore W3134747341C12722491 @default.
- W3134747341 hasConceptScore W3134747341C127561419 @default.
- W3134747341 hasConceptScore W3134747341C134018914 @default.
- W3134747341 hasConceptScore W3134747341C178790620 @default.
- W3134747341 hasConceptScore W3134747341C185592680 @default.
- W3134747341 hasConceptScore W3134747341C2776914184 @default.
- W3134747341 hasConceptScore W3134747341C2777622882 @default.
- W3134747341 hasConceptScore W3134747341C2859252 @default.
- W3134747341 hasConceptScore W3134747341C519581460 @default.
- W3134747341 hasConceptScore W3134747341C540031477 @default.
- W3134747341 hasConceptScore W3134747341C55493867 @default.
- W3134747341 hasConceptScore W3134747341C71924100 @default.
- W3134747341 hasConceptScore W3134747341C7836513 @default.
- W3134747341 hasConceptScore W3134747341C98274493 @default.
- W3134747341 hasIssue "S1" @default.
- W3134747341 hasLocation W31347473411 @default.
- W3134747341 hasOpenAccess W3134747341 @default.
- W3134747341 hasPrimaryLocation W31347473411 @default.
- W3134747341 hasRelatedWork W2008087125 @default.
- W3134747341 hasRelatedWork W2020449916 @default.
- W3134747341 hasRelatedWork W2021506741 @default.
- W3134747341 hasRelatedWork W2025703417 @default.
- W3134747341 hasRelatedWork W2089295326 @default.
- W3134747341 hasRelatedWork W2098776639 @default.
- W3134747341 hasRelatedWork W2191909859 @default.
- W3134747341 hasRelatedWork W2261942411 @default.
- W3134747341 hasRelatedWork W2409608972 @default.
- W3134747341 hasRelatedWork W4220896095 @default.
- W3134747341 hasVolume "24" @default.
- W3134747341 isParatext "false" @default.
- W3134747341 isRetracted "false" @default.
- W3134747341 magId "3134747341" @default.
- W3134747341 workType "article" @default.