Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134757317> ?p ?o ?g. }
- W3134757317 endingPage "752" @default.
- W3134757317 startingPage "737" @default.
- W3134757317 abstract "Undoubtedly, antibiotics have saved billions of lives, but lack of novel antibiotics, development of resistance mechanisms in almost all clinical isolates of bacteria, and recurrent infections caused by persistent bacteria hamper the successful treatment of the infections. Due to the widespread emergence of resistance, even the new families of anti-microbial agents have a short life expectancy. Drugs acting on a single target often lead to drug resistance and are associated with various side effects. For overcoming this problem, either multidrug therapy, or a single drug acting on multiple targets may be used. The latter is called ‘hybrid molecules,’ which are formed by clubbing two biologically active pharmacophores together, with or without an appropriate linker. In this rapidly evolving era, the development of natural product-based hybrid molecules may be a super-alternative to multidrug therapy, for combating drug resistance caused by various bacterial and fungal strains. Coumarins (benzopyran-2-one) are one of the earliest reported plant secondary metabolites having a clinically proven diverse range of pharmacological properties. On the other hand, 1,2,3-triazole is a common pharmacophore in many drugs responsible for polar interactions, improving the solubility and binding affinity to biomolecular targets. In this review, we discuss recent advances in Coumarin-1,2,3-triazole hybrids as potential anti-bacterial agents, aiming to provide a useful platform for the exploration of new leads with a broader spectrum, more effectiveness and less toxicity with multiple modes of action for the development of cost-effective and safer drugs in the future." @default.
- W3134757317 created "2021-03-15" @default.
- W3134757317 creator A5050152178 @default.
- W3134757317 date "2021-03-01" @default.
- W3134757317 modified "2023-10-05" @default.
- W3134757317 title "Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance" @default.
- W3134757317 cites W1161204293 @default.
- W3134757317 cites W1543687478 @default.
- W3134757317 cites W1582926274 @default.
- W3134757317 cites W158859405 @default.
- W3134757317 cites W1596214742 @default.
- W3134757317 cites W1795471827 @default.
- W3134757317 cites W1854010492 @default.
- W3134757317 cites W1926864368 @default.
- W3134757317 cites W1955189078 @default.
- W3134757317 cites W1967340332 @default.
- W3134757317 cites W1968056778 @default.
- W3134757317 cites W1968551929 @default.
- W3134757317 cites W1977851521 @default.
- W3134757317 cites W1978970152 @default.
- W3134757317 cites W1982998720 @default.
- W3134757317 cites W1986303437 @default.
- W3134757317 cites W1986748032 @default.
- W3134757317 cites W1989325640 @default.
- W3134757317 cites W1991352290 @default.
- W3134757317 cites W1992716708 @default.
- W3134757317 cites W2000205756 @default.
- W3134757317 cites W2009933778 @default.
- W3134757317 cites W2011154259 @default.
- W3134757317 cites W2015207425 @default.
- W3134757317 cites W2020520400 @default.
- W3134757317 cites W2024677109 @default.
- W3134757317 cites W2028157997 @default.
- W3134757317 cites W2028733293 @default.
- W3134757317 cites W2033588393 @default.
- W3134757317 cites W2036379697 @default.
- W3134757317 cites W2039052502 @default.
- W3134757317 cites W2049365002 @default.
- W3134757317 cites W2050665611 @default.
- W3134757317 cites W2051124828 @default.
- W3134757317 cites W2052856663 @default.
- W3134757317 cites W2053696392 @default.
- W3134757317 cites W2056017836 @default.
- W3134757317 cites W2058952776 @default.
- W3134757317 cites W2064750848 @default.
- W3134757317 cites W2067278945 @default.
- W3134757317 cites W2067756068 @default.
- W3134757317 cites W2075131015 @default.
- W3134757317 cites W2075387930 @default.
- W3134757317 cites W2079403691 @default.
- W3134757317 cites W2081302141 @default.
- W3134757317 cites W2081794610 @default.
- W3134757317 cites W2085222860 @default.
- W3134757317 cites W2086579500 @default.
- W3134757317 cites W2087807389 @default.
- W3134757317 cites W2109021882 @default.
- W3134757317 cites W2117048089 @default.
- W3134757317 cites W2129605627 @default.
- W3134757317 cites W2140353364 @default.
- W3134757317 cites W2145952139 @default.
- W3134757317 cites W2146593189 @default.
- W3134757317 cites W2147995249 @default.
- W3134757317 cites W2155172531 @default.
- W3134757317 cites W2156397294 @default.
- W3134757317 cites W2162331245 @default.
- W3134757317 cites W2165091681 @default.
- W3134757317 cites W2165625788 @default.
- W3134757317 cites W2167319421 @default.
- W3134757317 cites W2167763583 @default.
- W3134757317 cites W2178929000 @default.
- W3134757317 cites W2180652238 @default.
- W3134757317 cites W2240068210 @default.
- W3134757317 cites W2255841639 @default.
- W3134757317 cites W2285503715 @default.
- W3134757317 cites W2289408666 @default.
- W3134757317 cites W2296758087 @default.
- W3134757317 cites W2315267959 @default.
- W3134757317 cites W2315479558 @default.
- W3134757317 cites W2316777574 @default.
- W3134757317 cites W2318990336 @default.
- W3134757317 cites W2321441869 @default.
- W3134757317 cites W2326148267 @default.
- W3134757317 cites W2326418539 @default.
- W3134757317 cites W2329199725 @default.
- W3134757317 cites W2329745060 @default.
- W3134757317 cites W2333725990 @default.
- W3134757317 cites W2342805349 @default.
- W3134757317 cites W2345679427 @default.
- W3134757317 cites W2370199711 @default.
- W3134757317 cites W2417814439 @default.
- W3134757317 cites W2418273625 @default.
- W3134757317 cites W2465352794 @default.
- W3134757317 cites W2471503074 @default.
- W3134757317 cites W2471936468 @default.
- W3134757317 cites W2478185850 @default.
- W3134757317 cites W2484434874 @default.
- W3134757317 cites W2507508898 @default.
- W3134757317 cites W2512097690 @default.