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• W3134760705 endingPage "108796" @default.
• W3134760705 startingPage "108796" @default.
• W3134760705 abstract "Mechanical signals, such as those evoked by maximal-intensity contractions (MICs), can induce an increase in muscle mass. Rapamycin-sensitive signaling events are widely implicated in the regulation of this process; however, recent studies indicate that rapamycin-insensitive signaling events are also involved. Thus, to identify these events, we generate a map of the MIC-regulated and rapamycin-sensitive phosphoproteome. In total, we quantify more than 10,000 unique phosphorylation sites and find that more than 2,000 of these sites are significantly affected by MICs, but remarkably, only 38 of the MIC-regulated events are mediated through a rapamycin-sensitive mechanism. Further interrogation of the rapamycin-insensitive phosphorylation events identifies the S473 residue on Tripartite Motif-Containing 28 (TRIM28) as one of the most robust MIC-regulated phosphorylation sites, and extensive follow-up studies suggest that TRIM28 significantly contributes to the homeostatic regulation of muscle size and function as well as the hypertrophy that occurs in response to increased mechanical loading." @default.
• W3134760705 created "2021-03-15" @default.
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• W3134760705 creator A5089920047 @default.
• W3134760705 date "2021-03-01" @default.
• W3134760705 modified "2023-10-17" @default.
• W3134760705 title "Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function" @default.
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• W3134760705 cites W1574644425 @default.
• W3134760705 cites W1825669598 @default.
• W3134760705 cites W1839260472 @default.
• W3134760705 cites W1930333778 @default.
• W3134760705 cites W1956773599 @default.
• W3134760705 cites W1967199837 @default.
• W3134760705 cites W1974706622 @default.
• W3134760705 cites W1983394549 @default.
• W3134760705 cites W1990518016 @default.
• W3134760705 cites W1992970966 @default.
• W3134760705 cites W1995480133 @default.
• W3134760705 cites W2002583991 @default.
• W3134760705 cites W2005101201 @default.
• W3134760705 cites W2014891807 @default.
• W3134760705 cites W2020478281 @default.
• W3134760705 cites W2023470228 @default.
• W3134760705 cites W2026926544 @default.
• W3134760705 cites W2030411275 @default.
• W3134760705 cites W2038806256 @default.
• W3134760705 cites W2043274355 @default.
• W3134760705 cites W2053550953 @default.
• W3134760705 cites W2060505007 @default.
• W3134760705 cites W2062056760 @default.
• W3134760705 cites W2073285188 @default.
• W3134760705 cites W2077109432 @default.
• W3134760705 cites W2080752012 @default.
• W3134760705 cites W2081098333 @default.
• W3134760705 cites W2081262189 @default.
• W3134760705 cites W2094049721 @default.
• W3134760705 cites W2096028222 @default.
• W3134760705 cites W2097408175 @default.
• W3134760705 cites W2105597626 @default.
• W3134760705 cites W2109488005 @default.
• W3134760705 cites W2110335186 @default.
• W3134760705 cites W2117741579 @default.
• W3134760705 cites W2123064842 @default.
• W3134760705 cites W2130025116 @default.
• W3134760705 cites W2133113184 @default.
• W3134760705 cites W2133465414 @default.
• W3134760705 cites W2142131902 @default.
• W3134760705 cites W2145009991 @default.
• W3134760705 cites W2145272227 @default.
• W3134760705 cites W2146512944 @default.
• W3134760705 cites W2155511470 @default.
• W3134760705 cites W2155591792 @default.
• W3134760705 cites W2157306000 @default.
• W3134760705 cites W2158217645 @default.
• W3134760705 cites W2163819745 @default.
• W3134760705 cites W2170776626 @default.
• W3134760705 cites W2314581397 @default.
• W3134760705 cites W2339005651 @default.
• W3134760705 cites W2340797004 @default.
• W3134760705 cites W2402585100 @default.
• W3134760705 cites W2442313203 @default.
• W3134760705 cites W2463195069 @default.
• W3134760705 cites W2502051521 @default.
• W3134760705 cites W2517574975 @default.
• W3134760705 cites W2554252457 @default.
• W3134760705 cites W2568992328 @default.
• W3134760705 cites W2618770807 @default.
• W3134760705 cites W2757965705 @default.
• W3134760705 cites W2770225202 @default.
• W3134760705 cites W2785201697 @default.
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• W3134760705 cites W2897539462 @default.
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• W3134760705 doi "https://doi.org/10.1016/j.celrep.2021.108796" @default.
• W3134760705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7967290" @default.
• W3134760705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33657380" @default.
• W3134760705 hasPublicationYear "2021" @default.
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