FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134766907> ?p ?o ?g. }

• W3134766907 endingPage "3334" @default.
• W3134766907 startingPage "3325" @default.
• W3134766907 abstract "Abstract Purpose Radium-223 is a life-prolonging therapy for castration-resistant prostate cancer (CRPC) patients with symptomatic bone metastases. However, validated biomarkers for response monitoring are lacking. The study aim was to investigate whether early alkaline phosphatase (ALP) dynamics after the first radium-223 injection can act as surrogate marker for overall survival (OS). Methods This retrospective multicenter study included consecutive CRPC patients treated with radium-223. Patients were divided into four subgroups based on baseline ALP level (normal/elevated) and early ALP response, defined as ≥10% ALP decrease after the first radium-223 injection. Primary endpoint was OS among the subgroups. Secondary endpoints included time to first skeletal-related event, time to ALP progression, and treatment completion rate. Results A total of 180 patients were included for analysis. Median OS was 13.5 months (95% confidence interval 11.5–15.5). Patients with elevated baseline ALP without ALP response after the first injection had significantly worse OS when compared to all other patients (median OS 7.9 months versus 15.7 months, hazard ratio 2.56, 95% confidence interval 1.73–3.80, P < 0.001). Multivariate analysis demonstrated that elevated baseline ALP without ALP response after the first injection, the number of prior systemic therapies, baseline LDH level, and baseline ECOG performance status were prognostic factors of OS. Patients with elevated baseline ALP without ALP response after the first injection had significantly shorter times to ALP progression and first skeletal-related event, and more frequently discontinued radium-223 therapy when compared to other patients. Conclusion Early treatment–induced changes in ALP after one radium-223 injection were associated with OS in metastatic CRPC patients." @default.
• W3134766907 created "2021-03-15" @default.
• W3134766907 creator A5004159775 @default.
• W3134766907 creator A5014704217 @default.
• W3134766907 creator A5026265347 @default.
• W3134766907 creator A5036825889 @default.
• W3134766907 creator A5047432014 @default.
• W3134766907 creator A5085138741 @default.
• W3134766907 creator A5087575109 @default.
• W3134766907 creator A5088582666 @default.
• W3134766907 date "2021-03-08" @default.
• W3134766907 modified "2023-10-17" @default.
• W3134766907 title "Early alkaline phosphatase dynamics as biomarker of survival in metastatic castration-resistant prostate cancer patients treated with radium-223" @default.
• W3134766907 cites W1975577875 @default.
• W3134766907 cites W1999742227 @default.
• W3134766907 cites W2065574422 @default.
• W3134766907 cites W2115962082 @default.
• W3134766907 cites W2139995572 @default.
• W3134766907 cites W2141454098 @default.
• W3134766907 cites W2158639339 @default.
• W3134766907 cites W2170731023 @default.
• W3134766907 cites W2196689106 @default.
• W3134766907 cites W2278392405 @default.
• W3134766907 cites W2483834070 @default.
• W3134766907 cites W2511755939 @default.
• W3134766907 cites W2518834028 @default.
• W3134766907 cites W2565838866 @default.
• W3134766907 cites W2588172683 @default.
• W3134766907 cites W2604062834 @default.
• W3134766907 cites W2607894842 @default.
• W3134766907 cites W2770766940 @default.
• W3134766907 cites W2808859772 @default.
• W3134766907 cites W2839363354 @default.
• W3134766907 cites W2901304288 @default.
• W3134766907 cites W2911490798 @default.
• W3134766907 cites W2925184412 @default.
• W3134766907 cites W2946986050 @default.
• W3134766907 cites W2999356516 @default.
• W3134766907 cites W3014540548 @default.
• W3134766907 cites W3022950837 @default.
• W3134766907 cites W3032592962 @default.
• W3134766907 doi "https://doi.org/10.1007/s00259-021-05283-6" @default.
• W3134766907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8426246" @default.
• W3134766907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33686456" @default.
• W3134766907 hasPublicationYear "2021" @default.
• W3134766907 type Work @default.
• W3134766907 sameAs 3134766907 @default.
• W3134766907 citedByCount "11" @default.
• W3134766907 countsByYear W31347669072021 @default.
• W3134766907 countsByYear W31347669072022 @default.
• W3134766907 countsByYear W31347669072023 @default.
• W3134766907 crossrefType "journal-article" @default.
• W3134766907 hasAuthorship W3134766907A5004159775 @default.
• W3134766907 hasAuthorship W3134766907A5014704217 @default.
• W3134766907 hasAuthorship W3134766907A5026265347 @default.
• W3134766907 hasAuthorship W3134766907A5036825889 @default.
• W3134766907 hasAuthorship W3134766907A5047432014 @default.
• W3134766907 hasAuthorship W3134766907A5085138741 @default.
• W3134766907 hasAuthorship W3134766907A5087575109 @default.
• W3134766907 hasAuthorship W3134766907A5088582666 @default.
• W3134766907 hasBestOaLocation W31347669071 @default.
• W3134766907 hasConcept C121608353 @default.
• W3134766907 hasConcept C126322002 @default.
• W3134766907 hasConcept C126894567 @default.
• W3134766907 hasConcept C141341695 @default.
• W3134766907 hasConcept C143998085 @default.
• W3134766907 hasConcept C160160445 @default.
• W3134766907 hasConcept C181199279 @default.
• W3134766907 hasConcept C185592680 @default.
• W3134766907 hasConcept C203092338 @default.
• W3134766907 hasConcept C207103383 @default.
• W3134766907 hasConcept C2777783956 @default.
• W3134766907 hasConcept C2780192828 @default.
• W3134766907 hasConcept C2780737065 @default.
• W3134766907 hasConcept C2781197716 @default.
• W3134766907 hasConcept C44249647 @default.
• W3134766907 hasConcept C535046627 @default.
• W3134766907 hasConcept C55493867 @default.
• W3134766907 hasConcept C71924100 @default.
• W3134766907 hasConcept C90924648 @default.
• W3134766907 hasConceptScore W3134766907C121608353 @default.
• W3134766907 hasConceptScore W3134766907C126322002 @default.
• W3134766907 hasConceptScore W3134766907C126894567 @default.
• W3134766907 hasConceptScore W3134766907C141341695 @default.
• W3134766907 hasConceptScore W3134766907C143998085 @default.
• W3134766907 hasConceptScore W3134766907C160160445 @default.
• W3134766907 hasConceptScore W3134766907C181199279 @default.
• W3134766907 hasConceptScore W3134766907C185592680 @default.
• W3134766907 hasConceptScore W3134766907C203092338 @default.
• W3134766907 hasConceptScore W3134766907C207103383 @default.
• W3134766907 hasConceptScore W3134766907C2777783956 @default.
• W3134766907 hasConceptScore W3134766907C2780192828 @default.
• W3134766907 hasConceptScore W3134766907C2780737065 @default.
• W3134766907 hasConceptScore W3134766907C2781197716 @default.
• W3134766907 hasConceptScore W3134766907C44249647 @default.
• W3134766907 hasConceptScore W3134766907C535046627 @default.
• W3134766907 hasConceptScore W3134766907C55493867 @default.
• W3134766907 hasConceptScore W3134766907C71924100 @default.

• next