FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134774336> ?p ?o ?g. }

• W3134774336 endingPage "101912" @default.
• W3134774336 startingPage "101912" @default.
• W3134774336 abstract "Copper (Cu) is a trace element necessary in animals as well as human beings. However, excessive Cu is toxic to immunocytes, but the precise mechanism is largely unclear so far. This work was conducted aiming to examine the Cu-mediated autophagy mechanism together with its role in Cu toxicology in RAW264.7 cells. Here, we demonstrated that CuSO4 reduced the cell viability depending on its dose. CuSO4 could obviously increase autophagy in RAW264.7 cells. According to the obtained results, CuSO4 induced autophagy through Akt/AMPK/mTOR pathway which characterized by down regulation of p-Akt (Ser473)/Akt, p-mTOR/mTOR, p-ULK1(Ser757)/ULK1 and subsequent up-regulation of p-AMPKα/AMPKα and p-ULK1(Ser555)/ULK1. Furthermore, CuSO4 significantly induced the production of mitochondrial reactive oxygen species (mtROS). In addition, CuSO4-mediated apoptosis and autophagy might be suppressed through suppressing mtROS generation by exposure to Mito-TEMPO. Intriguingly, autophagy promotion with rapamycin could decrease the apoptosis and the inhibition of autophagy with knock down Atg5 could enhance the apoptosis induced by CuSO4. Moreover, our results suggested that mtROS is the original cause in CuSO4-induced apoptosis and autophagy. Additionally, CuSO4 induced autophagy through mtROS-dependent Akt/AMPK/mTOR signalling pathwayin RAW264.7 cells. Moreover, autophagy activation might potentially generate a protection mechanism for improving CuSO4-induced RAW264.7 cell apoptosis." @default.
• W3134774336 created "2021-03-15" @default.
• W3134774336 creator A5001492813 @default.
• W3134774336 creator A5007468197 @default.
• W3134774336 creator A5021634891 @default.
• W3134774336 creator A5023650230 @default.
• W3134774336 creator A5024795666 @default.
• W3134774336 creator A5042241049 @default.
• W3134774336 creator A5044738030 @default.
• W3134774336 creator A5048965407 @default.
• W3134774336 creator A5065357028 @default.
• W3134774336 creator A5089594083 @default.
• W3134774336 date "2021-05-01" @default.
• W3134774336 modified "2023-10-18" @default.
• W3134774336 title "mtROS-mediated Akt/AMPK/mTOR pathway was involved in Copper-induced autophagy and it attenuates Copper-induced apoptosis in RAW264.7 mouse monocytes" @default.
• W3134774336 cites W183547841 @default.
• W3134774336 cites W1985124617 @default.
• W3134774336 cites W2055971882 @default.
• W3134774336 cites W2115596383 @default.
• W3134774336 cites W2543900640 @default.
• W3134774336 cites W2897503237 @default.
• W3134774336 cites W2899280203 @default.
• W3134774336 cites W2943743584 @default.
• W3134774336 cites W2971594637 @default.
• W3134774336 cites W2998787758 @default.
• W3134774336 cites W3003463158 @default.
• W3134774336 cites W3011699272 @default.
• W3134774336 cites W3021737582 @default.
• W3134774336 cites W3036118684 @default.
• W3134774336 cites W3046544302 @default.
• W3134774336 cites W3081871879 @default.
• W3134774336 cites W3091168166 @default.
• W3134774336 cites W3106975069 @default.
• W3134774336 cites W3109353003 @default.
• W3134774336 cites W3112892124 @default.
• W3134774336 cites W3033567208 @default.
• W3134774336 doi "https://doi.org/10.1016/j.redox.2021.101912" @default.
• W3134774336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7944049" @default.
• W3134774336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33706171" @default.
• W3134774336 hasPublicationYear "2021" @default.
• W3134774336 type Work @default.
• W3134774336 sameAs 3134774336 @default.
• W3134774336 citedByCount "34" @default.
• W3134774336 countsByYear W31347743362021 @default.
• W3134774336 countsByYear W31347743362022 @default.
• W3134774336 countsByYear W31347743362023 @default.
• W3134774336 crossrefType "journal-article" @default.
• W3134774336 hasAuthorship W3134774336A5001492813 @default.
• W3134774336 hasAuthorship W3134774336A5007468197 @default.
• W3134774336 hasAuthorship W3134774336A5021634891 @default.
• W3134774336 hasAuthorship W3134774336A5023650230 @default.
• W3134774336 hasAuthorship W3134774336A5024795666 @default.
• W3134774336 hasAuthorship W3134774336A5042241049 @default.
• W3134774336 hasAuthorship W3134774336A5044738030 @default.
• W3134774336 hasAuthorship W3134774336A5048965407 @default.
• W3134774336 hasAuthorship W3134774336A5065357028 @default.
• W3134774336 hasAuthorship W3134774336A5089594083 @default.
• W3134774336 hasBestOaLocation W31347743361 @default.
• W3134774336 hasConcept C107846503 @default.
• W3134774336 hasConcept C11960822 @default.
• W3134774336 hasConcept C185592680 @default.
• W3134774336 hasConcept C190283241 @default.
• W3134774336 hasConcept C203522944 @default.
• W3134774336 hasConcept C2780124434 @default.
• W3134774336 hasConcept C2781000418 @default.
• W3134774336 hasConcept C502942594 @default.
• W3134774336 hasConcept C55493867 @default.
• W3134774336 hasConcept C62478195 @default.
• W3134774336 hasConcept C71680706 @default.
• W3134774336 hasConcept C75217442 @default.
• W3134774336 hasConcept C86554907 @default.
• W3134774336 hasConcept C86803240 @default.
• W3134774336 hasConcept C95444343 @default.
• W3134774336 hasConcept C97029542 @default.
• W3134774336 hasConcept C98490376 @default.
• W3134774336 hasConceptScore W3134774336C107846503 @default.
• W3134774336 hasConceptScore W3134774336C11960822 @default.
• W3134774336 hasConceptScore W3134774336C185592680 @default.
• W3134774336 hasConceptScore W3134774336C190283241 @default.
• W3134774336 hasConceptScore W3134774336C203522944 @default.
• W3134774336 hasConceptScore W3134774336C2780124434 @default.
• W3134774336 hasConceptScore W3134774336C2781000418 @default.
• W3134774336 hasConceptScore W3134774336C502942594 @default.
• W3134774336 hasConceptScore W3134774336C55493867 @default.
• W3134774336 hasConceptScore W3134774336C62478195 @default.
• W3134774336 hasConceptScore W3134774336C71680706 @default.
• W3134774336 hasConceptScore W3134774336C75217442 @default.
• W3134774336 hasConceptScore W3134774336C86554907 @default.
• W3134774336 hasConceptScore W3134774336C86803240 @default.
• W3134774336 hasConceptScore W3134774336C95444343 @default.
• W3134774336 hasConceptScore W3134774336C97029542 @default.
• W3134774336 hasConceptScore W3134774336C98490376 @default.
• W3134774336 hasFunder F4320333335 @default.
• W3134774336 hasLocation W31347743361 @default.
• W3134774336 hasLocation W31347743362 @default.
• W3134774336 hasLocation W31347743363 @default.
• W3134774336 hasOpenAccess W3134774336 @default.
• W3134774336 hasPrimaryLocation W31347743361 @default.

• next