FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134775478> ?p ?o ?g. }

• W3134775478 endingPage "20210006" @default.
• W3134775478 startingPage "20210006" @default.
• W3134775478 abstract "Compare a quantitative, algorithm-driven, and qualitative, pathologist-driven, scoring of radiation-induced pulmonary fibrosis (RIPF). And using these scoring models to derive preliminary comparisons on the effects of different mesenchymal stem cell (MSC) administration modalities in reducing RIPF.25 rats were randomized into 5 groups: non-irradiated control (CG), irradiated control (CR), intraperitoneally administered granulocyte-macrophage colony stimulating factor or GM-CSF (Drug), intravascularly administered MSC (IV), and intratracheally administered MSC (IT). All groups, except CG, received an 18 Gy conformal dose to the right lung. Drug, IV and IT groups were treated immediately after irradiation. After 24 weeks of observation, rats were euthanized, their lungs excised, fixed and stained with Masson's Trichrome. Samples were anonymized and RIPF was scored qualitatively by a certified pathologist and quantitatively using ImageScope. An analysis of association was conducted, and two binary classifiers trained to validate the integrity of both qualitative and quantitative scoring. Differences between the treatment groups, as assessed by the pathologist score, were then tested by variance component analysis and mixed models for differences in RIPF outcomes.There is agreement between qualitative and quantitative scoring for RIPF grades from 4 to 7. Both classifiers performed similarly on the testing set (AUC = 0.923) indicating accordance between the qualitative and quantitative scoring. For comparisons between MSC infusion modalities, the Drug group had better outcomes (mean pathologist scoring of 3.96), correlating with significantly better RIPF outcomes than IV [lower by 0.97, p = 0.047, 95% CI = (0.013, 1.918)] and resulting in an improvement over CR [lower by 0.93, p = 0.037, 95% CI = (0.062, 1.800].Quantitative image analysis may help in the assessment of therapeutic interventions for RIPF and can serve as a scoring surrogate in differentiating between severe and mild cases of RIPF. Preliminary data demonstrate that the use of GM-CSF was best correlated with lower RIPF severity.Quantitative image analysis can be a viable supplemental system of quality control and triaging in situations where pathologist work hours or resources are limited. The use of different MSC administration methods can result in different degrees of MSC efficacy and study outcomes." @default.
• W3134775478 created "2021-03-15" @default.
• W3134775478 creator A5008289966 @default.
• W3134775478 creator A5014479717 @default.
• W3134775478 creator A5051585182 @default.
• W3134775478 creator A5054681353 @default.
• W3134775478 creator A5055938751 @default.
• W3134775478 creator A5062157572 @default.
• W3134775478 creator A5071233739 @default.
• W3134775478 creator A5090517775 @default.
• W3134775478 creator A5091724212 @default.
• W3134775478 date "2021-01-01" @default.
• W3134775478 modified "2023-10-18" @default.
• W3134775478 title "Comparison of quantitative and qualitative scoring approaches for radiation-induced pulmonary fibrosis as applied to a preliminary investigation into the efficacy of mesenchymal stem cell delivery methods in a rat model" @default.
• W3134775478 cites W1275124738 @default.
• W3134775478 cites W1510440645 @default.
• W3134775478 cites W1570784805 @default.
• W3134775478 cites W1845769873 @default.
• W3134775478 cites W1906573204 @default.
• W3134775478 cites W1916902066 @default.
• W3134775478 cites W1977199437 @default.
• W3134775478 cites W1980246060 @default.
• W3134775478 cites W1992752163 @default.
• W3134775478 cites W1998194680 @default.
• W3134775478 cites W2000584719 @default.
• W3134775478 cites W2001518113 @default.
• W3134775478 cites W2009559340 @default.
• W3134775478 cites W2009645185 @default.
• W3134775478 cites W2012951520 @default.
• W3134775478 cites W2016347517 @default.
• W3134775478 cites W2019303062 @default.
• W3134775478 cites W2021916724 @default.
• W3134775478 cites W2030927418 @default.
• W3134775478 cites W2031790029 @default.
• W3134775478 cites W2033075194 @default.
• W3134775478 cites W2034555062 @default.
• W3134775478 cites W2034974797 @default.
• W3134775478 cites W2045341839 @default.
• W3134775478 cites W2049784854 @default.
• W3134775478 cites W2052895135 @default.
• W3134775478 cites W2062410438 @default.
• W3134775478 cites W2077356917 @default.
• W3134775478 cites W2080698857 @default.
• W3134775478 cites W2081285252 @default.
• W3134775478 cites W2084947514 @default.
• W3134775478 cites W2085722950 @default.
• W3134775478 cites W2093004262 @default.
• W3134775478 cites W2097029475 @default.
• W3134775478 cites W2106065367 @default.
• W3134775478 cites W2109127788 @default.
• W3134775478 cites W2124056092 @default.
• W3134775478 cites W2147156629 @default.
• W3134775478 cites W2150103989 @default.
• W3134775478 cites W2154773716 @default.
• W3134775478 cites W2166342852 @default.
• W3134775478 cites W2207837055 @default.
• W3134775478 cites W2241389603 @default.
• W3134775478 cites W2315083176 @default.
• W3134775478 cites W2483737713 @default.
• W3134775478 cites W2579775660 @default.
• W3134775478 cites W2791633572 @default.
• W3134775478 cites W2907357671 @default.
• W3134775478 cites W2968659686 @default.
• W3134775478 cites W2975448584 @default.
• W3134775478 cites W2318041041 @default.
• W3134775478 doi "https://doi.org/10.1259/bjro.20210006" @default.
• W3134775478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8320116" @default.
• W3134775478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34381940" @default.
• W3134775478 hasPublicationYear "2021" @default.
• W3134775478 type Work @default.
• W3134775478 sameAs 3134775478 @default.
• W3134775478 citedByCount "0" @default.
• W3134775478 crossrefType "journal-article" @default.
• W3134775478 hasAuthorship W3134775478A5008289966 @default.
• W3134775478 hasAuthorship W3134775478A5014479717 @default.
• W3134775478 hasAuthorship W3134775478A5051585182 @default.
• W3134775478 hasAuthorship W3134775478A5054681353 @default.
• W3134775478 hasAuthorship W3134775478A5055938751 @default.
• W3134775478 hasAuthorship W3134775478A5062157572 @default.
• W3134775478 hasAuthorship W3134775478A5071233739 @default.
• W3134775478 hasAuthorship W3134775478A5090517775 @default.
• W3134775478 hasAuthorship W3134775478A5091724212 @default.
• W3134775478 hasBestOaLocation W31347754782 @default.
• W3134775478 hasConcept C112930515 @default.
• W3134775478 hasConcept C126322002 @default.
• W3134775478 hasConcept C141071460 @default.
• W3134775478 hasConcept C142724271 @default.
• W3134775478 hasConcept C198826908 @default.
• W3134775478 hasConcept C2780559512 @default.
• W3134775478 hasConcept C2984588014 @default.
• W3134775478 hasConcept C2989005 @default.
• W3134775478 hasConcept C71924100 @default.
• W3134775478 hasConceptScore W3134775478C112930515 @default.
• W3134775478 hasConceptScore W3134775478C126322002 @default.
• W3134775478 hasConceptScore W3134775478C141071460 @default.
• W3134775478 hasConceptScore W3134775478C142724271 @default.
• W3134775478 hasConceptScore W3134775478C198826908 @default.
• W3134775478 hasConceptScore W3134775478C2780559512 @default.

• next