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- W3134779079 abstract "Abstract Background: This study was aimed to determine the circular RNA 5430(hsa_circ_0005430) in peripheral whole blood（PWB）from lung adenocarcinoma (LA) patients is a novel biomarker for screening LA. Methods: The expression levels of hsa_circ_0005430 in PWB from 20 LA patients and 10 healthy controls were performed using real-time quantitative reverse transcription-polymerase chain reaction(RT-qPCR). Serum CEA, CA199 and CA50 were detected by chemiluminescent immunoassay. Spearman’ correlation test was used to evaluate the correlation of hsa_circ_0005430 and clinical variables. The receiver operating characteristic (ROC) curve was established to evaluate its diagnostic value. Results: PWB hsa_circ_0005430 was significantly elevated in LA patients, comparing with healthy controls. There was no significant difference in hsa_circ_0005430 level among different pathological factors of LA. In these LA patients, we found a significant correlation between PWB hsa_circ_0005430 and disease activity, including carcinoembryonic antigen(CEA), carbohydrate antigen 199(CA199) and carbohydrate antigen 50 (CA50). ROC analysis showed that PWB hsa_circ_0005430 had an area under the curve(AUC) of 0.75 (95% CI 0.567-0.928, P < 0.001) to discriminate LA patients from controls with sensitivity of 0.900 and specificity of 0.65. The highest Youden index was 0.55 and the corresponding optimal cut-off value was 0.14. Conclusions: This study revealed that PWB hsa_circ_0005430 in LA may serve as a potential biomarker for LA patients diagnosis." @default.
- W3134779079 created "2021-03-15" @default.
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- W3134779079 date "2021-03-09" @default.
- W3134779079 modified "2023-09-25" @default.
- W3134779079 title "A Novel Peripheral Whole Blood hsa_circ_0005430 is a Potential Biomarker for Lung Adenocarcinoma" @default.
- W3134779079 doi "https://doi.org/10.21203/rs.3.rs-280319/v1" @default.
- W3134779079 hasPublicationYear "2021" @default.
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