Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134787449> ?p ?o ?g. }
- W3134787449 endingPage "232" @default.
- W3134787449 startingPage "204" @default.
- W3134787449 abstract "Glycosyltransferases (GTs) are responsible for the synthesis of a multitude of important glycosylated molecules. These enzymes catalyze the assembly of glycans and glycoconjugates through the transfer of sugar residues from activated donors onto various acceptor molecules. In most cases, the donor molecule consists of a sugar attached to the phosphate group of a nucleotide, but some GTs can use donors consisting of sugars attached to the phosphate groups of other molecules. Transfer of a sugar group from the donor can occur with retention or inversion of the stereochemical configuration of the anomeric center and thus GTs can be classified as either retaining or inverting. GTs have become attractive drug targets due to the important biological roles played by the various glycans that they assemble. Understanding GT structure and function has helped researchers to identify and develop small molecule inhibitors, and the emerging advances in high-throughput screening tools have made feasible the rapid discovery of novel GT inhibitors from diverse compound libraries. Apart from being therapeutic targets, GTs make useful tools as biocatalysts for the production of valuable glycosylated molecules. However, their use in enzymatic synthesis is often limited due to deficiencies in the desired enzyme characteristics. Insights on GT mechanisms and 3D protein structures has permitted structure-guided rational engineering strategies such as site-directed mutagenesis and domain swapping to enhance or modify GT functions. Furthermore, high-throughput GT screening platforms have not only proven to be valuable towards GT engineering by directed evolution, but they are also important tools in exploring the catalytic scope of natural and engineered GTs towards the production of novel glycosides." @default.
- W3134787449 created "2021-03-15" @default.
- W3134787449 creator A5003894257 @default.
- W3134787449 creator A5056822748 @default.
- W3134787449 creator A5082778085 @default.
- W3134787449 creator A5087120496 @default.
- W3134787449 date "2021-01-01" @default.
- W3134787449 modified "2023-09-25" @default.
- W3134787449 title "Controlling Glycosyltransferase Activity: Inhibition and Enzyme Engineering" @default.
- W3134787449 cites W105378468 @default.
- W3134787449 cites W1182461782 @default.
- W3134787449 cites W1484288251 @default.
- W3134787449 cites W1537868688 @default.
- W3134787449 cites W1594188197 @default.
- W3134787449 cites W1601406615 @default.
- W3134787449 cites W1619481003 @default.
- W3134787449 cites W167238971 @default.
- W3134787449 cites W173798027 @default.
- W3134787449 cites W1833091681 @default.
- W3134787449 cites W1862479421 @default.
- W3134787449 cites W1912870130 @default.
- W3134787449 cites W1963894798 @default.
- W3134787449 cites W1965466877 @default.
- W3134787449 cites W1965866496 @default.
- W3134787449 cites W1966180185 @default.
- W3134787449 cites W1967327013 @default.
- W3134787449 cites W1969242697 @default.
- W3134787449 cites W1969912034 @default.
- W3134787449 cites W1970677182 @default.
- W3134787449 cites W1976609472 @default.
- W3134787449 cites W1977950017 @default.
- W3134787449 cites W1982107327 @default.
- W3134787449 cites W1984294765 @default.
- W3134787449 cites W1986304000 @default.
- W3134787449 cites W1987394105 @default.
- W3134787449 cites W1988054641 @default.
- W3134787449 cites W1988158452 @default.
- W3134787449 cites W1989331104 @default.
- W3134787449 cites W1989730031 @default.
- W3134787449 cites W1990103381 @default.
- W3134787449 cites W1990471004 @default.
- W3134787449 cites W1990619404 @default.
- W3134787449 cites W1991700140 @default.
- W3134787449 cites W1993019691 @default.
- W3134787449 cites W1997261294 @default.
- W3134787449 cites W1998906741 @default.
- W3134787449 cites W1999147304 @default.
- W3134787449 cites W2000504553 @default.
- W3134787449 cites W2008832722 @default.
- W3134787449 cites W2009235154 @default.
- W3134787449 cites W2010620034 @default.
- W3134787449 cites W2011830019 @default.
- W3134787449 cites W2012906766 @default.
- W3134787449 cites W2014059162 @default.
- W3134787449 cites W2014638630 @default.
- W3134787449 cites W2015839491 @default.
- W3134787449 cites W2018454041 @default.
- W3134787449 cites W2023326794 @default.
- W3134787449 cites W2023479182 @default.
- W3134787449 cites W2028570140 @default.
- W3134787449 cites W2028752174 @default.
- W3134787449 cites W2029489645 @default.
- W3134787449 cites W2029711985 @default.
- W3134787449 cites W2032416810 @default.
- W3134787449 cites W2033567679 @default.
- W3134787449 cites W2034671083 @default.
- W3134787449 cites W2034830160 @default.
- W3134787449 cites W2040739287 @default.
- W3134787449 cites W2042506709 @default.
- W3134787449 cites W2042565484 @default.
- W3134787449 cites W2042807866 @default.
- W3134787449 cites W2044253796 @default.
- W3134787449 cites W2044575523 @default.
- W3134787449 cites W2046359913 @default.
- W3134787449 cites W2046386154 @default.
- W3134787449 cites W2046860202 @default.
- W3134787449 cites W2047070653 @default.
- W3134787449 cites W2049905838 @default.
- W3134787449 cites W2053470037 @default.
- W3134787449 cites W2056460576 @default.
- W3134787449 cites W2057051781 @default.
- W3134787449 cites W2060534420 @default.
- W3134787449 cites W2061367741 @default.
- W3134787449 cites W2061659012 @default.
- W3134787449 cites W2063952111 @default.
- W3134787449 cites W2065357509 @default.
- W3134787449 cites W2069639082 @default.
- W3134787449 cites W2070141843 @default.
- W3134787449 cites W2070666853 @default.
- W3134787449 cites W2071974088 @default.
- W3134787449 cites W2072651233 @default.
- W3134787449 cites W2074570966 @default.
- W3134787449 cites W2075038350 @default.
- W3134787449 cites W2077182467 @default.
- W3134787449 cites W2078917933 @default.
- W3134787449 cites W2079193450 @default.
- W3134787449 cites W2080462728 @default.
- W3134787449 cites W2082325881 @default.