FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134787461> ?p ?o ?g. }

• W3134787461 abstract "Abstract Natural products that possess alkyne or polyyne moieties have been isolated from a variety of biological sources. In bacteria their biosynthesis has been defined, however, the distribution of polyyne biosynthetic gene clusters (BGCs), and their evolutionary relationship to alkyne biosynthesis, have not been addressed. We explored the distribution of alkyne biosynthesis gene cassettes throughout bacteria, revealing evidence of multiple horizontal gene transfer events. Investigating the evolutionary connection between alkyne and polyyne biosynthesis identified a monophyletic clade possessing a conserved seven-gene cassette for polyyne biosynthesis. Mapping the diversity of these conserved genes revealed a phylogenetic clade representing a polyyne BGC in Pseudomonas, pgn , and subsequent pathway mutagenesis and analytical chemistry characterised the associated metabolite, protegencin. In addition to unifying and expanding our knowledge of polyyne diversity, our results show that alkyne and polyyne biosynthetic gene clusters are promiscuous within bacteria. Systematic mapping of conserved biosynthetic genes across bacterial genomic diversity has proven to be a successful method for discovering natural products." @default.
• W3134787461 created "2021-03-15" @default.
• W3134787461 creator A5011833651 @default.
• W3134787461 creator A5028687331 @default.
• W3134787461 creator A5033300640 @default.
• W3134787461 creator A5040664876 @default.
• W3134787461 creator A5046030535 @default.
• W3134787461 creator A5046344299 @default.
• W3134787461 creator A5050980307 @default.
• W3134787461 creator A5061465946 @default.
• W3134787461 creator A5066230640 @default.
• W3134787461 creator A5068676401 @default.
• W3134787461 creator A5079192656 @default.
• W3134787461 creator A5091137505 @default.
• W3134787461 date "2021-03-06" @default.
• W3134787461 modified "2023-10-15" @default.
• W3134787461 title "Exploration of polyyne biosynthetic gene cluster diversity in bacteria leads to the discovery of the Pseudomonas polyyne protegencin" @default.
• W3134787461 cites W1939764576 @default.
• W3134787461 cites W1968248059 @default.
• W3134787461 cites W2012112926 @default.
• W3134787461 cites W2014738810 @default.
• W3134787461 cites W2031611770 @default.
• W3134787461 cites W2032780542 @default.
• W3134787461 cites W2039779669 @default.
• W3134787461 cites W2046991545 @default.
• W3134787461 cites W2059252321 @default.
• W3134787461 cites W2062084967 @default.
• W3134787461 cites W2083698543 @default.
• W3134787461 cites W2096093282 @default.
• W3134787461 cites W2101291993 @default.
• W3134787461 cites W2114853012 @default.
• W3134787461 cites W2119586851 @default.
• W3134787461 cites W2122673596 @default.
• W3134787461 cites W2127036970 @default.
• W3134787461 cites W2128964206 @default.
• W3134787461 cites W2141052558 @default.
• W3134787461 cites W2148615699 @default.
• W3134787461 cites W2160378127 @default.
• W3134787461 cites W2168207613 @default.
• W3134787461 cites W2178637309 @default.
• W3134787461 cites W2410975458 @default.
• W3134787461 cites W2413203161 @default.
• W3134787461 cites W2552293521 @default.
• W3134787461 cites W2609052990 @default.
• W3134787461 cites W2731134224 @default.
• W3134787461 cites W2788593837 @default.
• W3134787461 cites W2803779844 @default.
• W3134787461 cites W2884008478 @default.
• W3134787461 cites W2919560887 @default.
• W3134787461 cites W3084925804 @default.
• W3134787461 doi "https://doi.org/10.1101/2021.03.05.433886" @default.
• W3134787461 hasPublicationYear "2021" @default.
• W3134787461 type Work @default.
• W3134787461 sameAs 3134787461 @default.
• W3134787461 citedByCount "1" @default.
• W3134787461 countsByYear W31347874612021 @default.
• W3134787461 crossrefType "posted-content" @default.
• W3134787461 hasAuthorship W3134787461A5011833651 @default.
• W3134787461 hasAuthorship W3134787461A5028687331 @default.
• W3134787461 hasAuthorship W3134787461A5033300640 @default.
• W3134787461 hasAuthorship W3134787461A5040664876 @default.
• W3134787461 hasAuthorship W3134787461A5046030535 @default.
• W3134787461 hasAuthorship W3134787461A5046344299 @default.
• W3134787461 hasAuthorship W3134787461A5050980307 @default.
• W3134787461 hasAuthorship W3134787461A5061465946 @default.
• W3134787461 hasAuthorship W3134787461A5066230640 @default.
• W3134787461 hasAuthorship W3134787461A5068676401 @default.
• W3134787461 hasAuthorship W3134787461A5079192656 @default.
• W3134787461 hasAuthorship W3134787461A5091137505 @default.
• W3134787461 hasBestOaLocation W31347874611 @default.
• W3134787461 hasConcept C104317684 @default.
• W3134787461 hasConcept C161790260 @default.
• W3134787461 hasConcept C16318435 @default.
• W3134787461 hasConcept C193252679 @default.
• W3134787461 hasConcept C2779012754 @default.
• W3134787461 hasConcept C36857842 @default.
• W3134787461 hasConcept C501734568 @default.
• W3134787461 hasConcept C523546767 @default.
• W3134787461 hasConcept C54355233 @default.
• W3134787461 hasConcept C553450214 @default.
• W3134787461 hasConcept C55493867 @default.
• W3134787461 hasConcept C70721500 @default.
• W3134787461 hasConcept C86803240 @default.
• W3134787461 hasConcept C92938381 @default.
• W3134787461 hasConceptScore W3134787461C104317684 @default.
• W3134787461 hasConceptScore W3134787461C161790260 @default.
• W3134787461 hasConceptScore W3134787461C16318435 @default.
• W3134787461 hasConceptScore W3134787461C193252679 @default.
• W3134787461 hasConceptScore W3134787461C2779012754 @default.
• W3134787461 hasConceptScore W3134787461C36857842 @default.
• W3134787461 hasConceptScore W3134787461C501734568 @default.
• W3134787461 hasConceptScore W3134787461C523546767 @default.
• W3134787461 hasConceptScore W3134787461C54355233 @default.
• W3134787461 hasConceptScore W3134787461C553450214 @default.
• W3134787461 hasConceptScore W3134787461C55493867 @default.
• W3134787461 hasConceptScore W3134787461C70721500 @default.
• W3134787461 hasConceptScore W3134787461C86803240 @default.
• W3134787461 hasConceptScore W3134787461C92938381 @default.
• W3134787461 hasLocation W31347874611 @default.
• W3134787461 hasOpenAccess W3134787461 @default.

• next