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• W3134792243 abstract "Abstract Prenatal testing has changed greatly over the past two decades, which may affect the diagnosis of congenital heart disease (CHD) in Down syndrome. The present study aimed to analyze changes in the prevalence and distribution of CHD diagnosed via ultrasonography and fetopathology in 462 fetuses with trisomy 21 between two consecutive 10‐year periods (1999–2018), as well as the associations between CHDs, ultrasound markers, and extracardiac malformations. Overall, the frequency of cardiovascular malformations in trisomy 21 was 27.7 and 26.5%, and ultrasound identified 70 and 62% of CHDs during these periods. A profound increase in first‐trimester ultrasound findings and associated anomalies with CHDs (ventricular septal defect, Tetralogy of Fallot) since 2009 were observed. Second‐trimester nonstructural heart abnormalities were associated with ultrasound anomalies (74%) and major extracardiac malformations (42.9%). During both study periods, mothers carrying fetuses with CHD were significantly younger than those without CHD ( p = 0.038, p = 0.009, respectively). Comparing the two 10‐year periods, there were no changes in the prevalence and detection of CHDs. Trend analysis revealed that, although the frequency of CHD remained stable, the diagnostic spectrum had shifted between the study periods. Detection of nonstructural heart abnormalities necessitates detailed follow‐up for cardiac/extracardiac malformations and chromosomal disorders." @default.
• W3134792243 created "2021-03-15" @default.
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• W3134792243 date "2021-03-08" @default.
• W3134792243 modified "2023-10-17" @default.
• W3134792243 title "Trends in the prenatal diagnosis of trisomy 21 show younger maternal age and shift in the distribution of congenital heart disease over a 20‐year period" @default.
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• W3134792243 doi "https://doi.org/10.1002/ajmg.a.62162" @default.
• W3134792243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33683014" @default.
• W3134792243 hasPublicationYear "2021" @default.
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