FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134796247> ?p ?o ?g. }

• W3134796247 endingPage "62" @default.
• W3134796247 startingPage "49" @default.
• W3134796247 abstract "Numerous studies over last decade have shown that functional capacity of neutrophil granulocytes (NG) determines the course and outcome of many diseases. Identification of phenotypic variants of functionally significant NG subpopulations is a new approach allows us to assess the adequacy or deficiency of NG involvement into infectious inflammation processes at molecular level. An opportunity of reorienting a deficient NG subpopulational phenotype in purulent inflammatory diseases due to the rearrangement of the receptor set induced by various immunotropic substances may serve as a key to recovery of normal NG functioning. Our aim was to study the effect of glucosaminylmuramyldipeptide (GMDP) under in vitro conditions upon the phenotypic profile of four functionally significant subpopulations, i.e., CD62L + CD63 - NG, CD62L + CD63 + NG and CD64 - CD32 + CD16 + CD11b + NG, CD64 + CD32 + CD16 + CD11b + NG, along with assessment of expression density of appropriate membrane molecules and NG microbicidal activity in the children with purulent inflammatory diseases. 90 samples of peripheral blood (PC) were taken from children 2 to 4 years old, including 12 children with minor purulent infection (MPI), and 7 children were studied as conditionally healthy controls. Their peripheral blood was incubated for 60 minutes at 37 °C with GMP (10 -6 g/l). Using flow cytometry technique, the relative numbers of some NG subpopulations, i.e., CD64 - CD16 + CD32 + CD11b + NG, CD64 + CD16 + CD32 + CD11b + NG, CD62L + CD63 - NG, CD62L + CD63 + NG were evaluated, and the phenotype features of each subpopulation were investigated according to the density of appropriate membrane molecule expression (MFI). In parallel, phagocytic and microbicidal activity of NG was tested in these study groups. The obtained data indicate for presence of for distinct NG subpopulations, both in healthy children and in children with MPI. We have revealed phenotypic transformation of the four studied NG subpopulations from MPI patients including disturbed phagocytic and microbicidal functions of the cells. Using of this in vitro system, we have shown that the transformed phenotype of the four functionally significant NG subpopulations of MPI patients was re-arranged under GMDP treatment. At the same time, the number of CD62L + CD63 + NG and CD64 - CD32 + CD16 + CD11b + NG subpopulations was increased, along with decreased amounts of CD64 + CD32 + CD16 + CD11b + NG and CD62L + CD63 - NG subpopulations, being accompanied by restoration of microbicidal activity of NGs. The obtained data allow us to accomplish current understanding of immunotropic effects of GMDP, and to extend the potential scope of its experimental and clinical application. The new data on GMDP effects revealed by in vitro system, i.e. phenotype rearrangement of functionally significant NG subpopulations CD64 - CD16 + CD32 + CD11b + , CD64 + CD16 + CD32 + CD11b + , CD62L + CD63 - , CD62L + CD63 + in atypical purulent inflammatory diseases in children, may be used in the future in order to develop innovative strategies of immunotherapy aiming for correction of NG dysfunction in children with MPI." @default.
• W3134796247 created "2021-03-15" @default.
• W3134796247 creator A5017743289 @default.
• W3134796247 creator A5017985589 @default.
• W3134796247 creator A5027669058 @default.
• W3134796247 creator A5038456406 @default.
• W3134796247 creator A5042473311 @default.
• W3134796247 creator A5045011419 @default.
• W3134796247 creator A5060241630 @default.
• W3134796247 creator A5070574731 @default.
• W3134796247 date "2021-03-01" @default.
• W3134796247 modified "2023-10-02" @default.
• W3134796247 title "In vitro phenotypic re-orientation of functionally important neutrophil subpopulations and their microbicidal activity in the children with purulent inflammatory diseases influenced by glucosaminil muramildipeptide" @default.
• W3134796247 cites W1641571396 @default.
• W3134796247 cites W1857235133 @default.
• W3134796247 cites W1964162643 @default.
• W3134796247 cites W2043586796 @default.
• W3134796247 cites W2062126728 @default.
• W3134796247 cites W2102292063 @default.
• W3134796247 cites W2115630027 @default.
• W3134796247 cites W2508381765 @default.
• W3134796247 cites W2509334199 @default.
• W3134796247 cites W2524572457 @default.
• W3134796247 cites W2547894750 @default.
• W3134796247 cites W2574678992 @default.
• W3134796247 cites W2616998810 @default.
• W3134796247 cites W2793297767 @default.
• W3134796247 cites W2804326218 @default.
• W3134796247 cites W3181492048 @default.
• W3134796247 doi "https://doi.org/10.15789/1563-0625-ivp-2136" @default.
• W3134796247 hasPublicationYear "2021" @default.
• W3134796247 type Work @default.
• W3134796247 sameAs 3134796247 @default.
• W3134796247 citedByCount "2" @default.
• W3134796247 countsByYear W31347962472023 @default.
• W3134796247 crossrefType "journal-article" @default.
• W3134796247 hasAuthorship W3134796247A5017743289 @default.
• W3134796247 hasAuthorship W3134796247A5017985589 @default.
• W3134796247 hasAuthorship W3134796247A5027669058 @default.
• W3134796247 hasAuthorship W3134796247A5038456406 @default.
• W3134796247 hasAuthorship W3134796247A5042473311 @default.
• W3134796247 hasAuthorship W3134796247A5045011419 @default.
• W3134796247 hasAuthorship W3134796247A5060241630 @default.
• W3134796247 hasAuthorship W3134796247A5070574731 @default.
• W3134796247 hasBestOaLocation W31347962471 @default.
• W3134796247 hasConcept C104317684 @default.
• W3134796247 hasConcept C114684123 @default.
• W3134796247 hasConcept C127716648 @default.
• W3134796247 hasConcept C145059251 @default.
• W3134796247 hasConcept C147483822 @default.
• W3134796247 hasConcept C153911025 @default.
• W3134796247 hasConcept C160448771 @default.
• W3134796247 hasConcept C1621761 @default.
• W3134796247 hasConcept C16224149 @default.
• W3134796247 hasConcept C167672396 @default.
• W3134796247 hasConcept C170493617 @default.
• W3134796247 hasConcept C171779818 @default.
• W3134796247 hasConcept C185592680 @default.
• W3134796247 hasConcept C202751555 @default.
• W3134796247 hasConcept C203014093 @default.
• W3134796247 hasConcept C20518536 @default.
• W3134796247 hasConcept C2776385711 @default.
• W3134796247 hasConcept C2776447464 @default.
• W3134796247 hasConcept C2779835222 @default.
• W3134796247 hasConcept C2781462264 @default.
• W3134796247 hasConcept C553184892 @default.
• W3134796247 hasConcept C55493867 @default.
• W3134796247 hasConcept C86803240 @default.
• W3134796247 hasConceptScore W3134796247C104317684 @default.
• W3134796247 hasConceptScore W3134796247C114684123 @default.
• W3134796247 hasConceptScore W3134796247C127716648 @default.
• W3134796247 hasConceptScore W3134796247C145059251 @default.
• W3134796247 hasConceptScore W3134796247C147483822 @default.
• W3134796247 hasConceptScore W3134796247C153911025 @default.
• W3134796247 hasConceptScore W3134796247C160448771 @default.
• W3134796247 hasConceptScore W3134796247C1621761 @default.
• W3134796247 hasConceptScore W3134796247C16224149 @default.
• W3134796247 hasConceptScore W3134796247C167672396 @default.
• W3134796247 hasConceptScore W3134796247C170493617 @default.
• W3134796247 hasConceptScore W3134796247C171779818 @default.
• W3134796247 hasConceptScore W3134796247C185592680 @default.
• W3134796247 hasConceptScore W3134796247C202751555 @default.
• W3134796247 hasConceptScore W3134796247C203014093 @default.
• W3134796247 hasConceptScore W3134796247C20518536 @default.
• W3134796247 hasConceptScore W3134796247C2776385711 @default.
• W3134796247 hasConceptScore W3134796247C2776447464 @default.
• W3134796247 hasConceptScore W3134796247C2779835222 @default.
• W3134796247 hasConceptScore W3134796247C2781462264 @default.
• W3134796247 hasConceptScore W3134796247C553184892 @default.
• W3134796247 hasConceptScore W3134796247C55493867 @default.
• W3134796247 hasConceptScore W3134796247C86803240 @default.
• W3134796247 hasIssue "1" @default.
• W3134796247 hasLocation W31347962471 @default.
• W3134796247 hasLocation W31347962472 @default.
• W3134796247 hasOpenAccess W3134796247 @default.
• W3134796247 hasPrimaryLocation W31347962471 @default.
• W3134796247 hasRelatedWork W2094420336 @default.
• W3134796247 hasRelatedWork W2188329062 @default.

• next