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• W3134799774 endingPage "146201" @default.
• W3134799774 startingPage "146201" @default.
• W3134799774 abstract "Although many COVID-19 patients isolate and recover at home, the dispersal of SARS-CoV-2 onto surfaces and dust within the home environment remains poorly understood. To investigate the distribution and persistence of SARS-CoV-2 in a home with COVID-19 positive occupants, samples were collected from a household with two confirmed COVID-19 cases (one adult and one child). Home surface swab and dust samples were collected two months after symptom onset (and one month after symptom resolution) in the household. The strength of the SARS-CoV-2 molecular signal in fomites varied as a function of sample location, surface material and cleaning practices. Notably, the SARS-CoV-2 RNA signal was detected at several locations throughout the household although cleaning appears to have attenuated the signal on many surfaces. Of the 24 surfaces sampled, 46% were SARS-CoV-2 positive at the time of sampling. The SARS-CoV-2 concentrations in dust recovered from floor and HVAC filter samples ranged from 104 to 105 N2 gene copies/g dust. While detection of viral RNA does not imply infectivity, this study confirms that the SARS-CoV-2 RNA signal can be detected at several locations within a COVID-19 isolation home and can persist after symptoms have resolved. In addition, the concentration of SARS-CoV-2 (normalized per unit mass of dust) recovered in home HVAC filters may prove useful for estimating SARS-CoV-2 airborne levels in homes. In this work, using the quantitative filter forensics methodology, we estimated an average integrated airborne SARS-CoV-2 concentration of 69 ± 43 copies/m3. This approach can be used to help building scientists and engineers develop best practices in homes with COVID-19 positive occupants." @default.
• W3134799774 created "2021-03-15" @default.
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• W3134799774 date "2021-07-01" @default.
• W3134799774 modified "2023-10-14" @default.
• W3134799774 title "Distribution of SARS-CoV-2 RNA signal in a home with COVID-19 positive occupants" @default.
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• W3134799774 doi "https://doi.org/10.1016/j.scitotenv.2021.146201" @default.
• W3134799774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7942153" @default.
• W3134799774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34030356" @default.
• W3134799774 hasPublicationYear "2021" @default.
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