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• W3134810127 endingPage "2366" @default.
• W3134810127 startingPage "2366" @default.
• W3134810127 abstract "Ischemia reperfusion injury is a complex process consisting of a seemingly chaotic but actually organized and compartmentalized shutdown of cell function, of which oxidative stress is a key component. Studying oxidative stress, which results in an imbalance between reactive oxygen species (ROS) production and antioxidant defense activity, is a multi-faceted issue, particularly considering the double function of ROS, assuming roles as physiological intracellular signals and as mediators of cellular component damage. Herein, we propose a comprehensive overview of the tools available to explore oxidative stress, particularly in the study of ischemia reperfusion. Applying chemistry as well as biology, we present the different models currently developed to study oxidative stress, spanning the vitro and the silico, discussing the advantages and the drawbacks of each set-up, including the issues relating to the use of in vitro hypoxia as a surrogate for ischemia. Having identified the limitations of historical models, we shall study new paradigms, including the use of stem cell-derived organoids, as a bridge between the in vitro and the in vivo comprising 3D intercellular interactions in vivo and versatile pathway investigations in vitro. We shall conclude this review by distancing ourselves from “wet” biology and reviewing the in silico, computer-based, mathematical modeling, and numerical simulation options: (a) molecular modeling with quantum chemistry and molecular dynamic algorithms, which facilitates the study of molecule-to-molecule interactions, and the integration of a compound in a dynamic environment (the plasma membrane...); (b) integrative systemic models, which can include many facets of complex mechanisms such as oxidative stress or ischemia reperfusion and help to formulate integrated predictions and to enhance understanding of dynamic interaction between pathways." @default.
• W3134810127 created "2021-03-15" @default.
• W3134810127 creator A5003319753 @default.
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• W3134810127 creator A5035470258 @default.
• W3134810127 creator A5054528440 @default.
• W3134810127 date "2021-02-27" @default.
• W3134810127 modified "2023-10-11" @default.
• W3134810127 title "Oxidative Stress Evaluation in Ischemia Reperfusion Models: Characteristics, Limits and Perspectives" @default.
• W3134810127 cites W107445082 @default.
• W3134810127 cites W1119486796 @default.
• W3134810127 cites W1421415727 @default.
• W3134810127 cites W1523213544 @default.
• W3134810127 cites W1557086791 @default.
• W3134810127 cites W1658252992 @default.
• W3134810127 cites W1809795104 @default.
• W3134810127 cites W1860238494 @default.
• W3134810127 cites W1965216303 @default.
• W3134810127 cites W1965336187 @default.
• W3134810127 cites W1966160892 @default.
• W3134810127 cites W1971585037 @default.
• W3134810127 cites W1972372733 @default.
• W3134810127 cites W1974128153 @default.
• W3134810127 cites W1977523316 @default.
• W3134810127 cites W1980132875 @default.
• W3134810127 cites W1984555524 @default.
• W3134810127 cites W1986645535 @default.
• W3134810127 cites W1990878156 @default.
• W3134810127 cites W1991722852 @default.
• W3134810127 cites W1999891390 @default.
• W3134810127 cites W2003079212 @default.
• W3134810127 cites W2005543791 @default.
• W3134810127 cites W2016189233 @default.
• W3134810127 cites W2021016128 @default.
• W3134810127 cites W2022788097 @default.
• W3134810127 cites W2026525843 @default.
• W3134810127 cites W2028871902 @default.
• W3134810127 cites W2032773079 @default.
• W3134810127 cites W2034683799 @default.
• W3134810127 cites W2035492487 @default.
• W3134810127 cites W2036127346 @default.
• W3134810127 cites W2045435533 @default.
• W3134810127 cites W2050186814 @default.
• W3134810127 cites W2056357865 @default.
• W3134810127 cites W2064078155 @default.
• W3134810127 cites W2064325695 @default.
• W3134810127 cites W2071415726 @default.
• W3134810127 cites W2073703119 @default.
• W3134810127 cites W2075686602 @default.
• W3134810127 cites W2076598575 @default.
• W3134810127 cites W2089558684 @default.
• W3134810127 cites W2093479140 @default.
• W3134810127 cites W2093636093 @default.
• W3134810127 cites W2094510532 @default.
• W3134810127 cites W2104562968 @default.
• W3134810127 cites W2116387951 @default.
• W3134810127 cites W2118906726 @default.
• W3134810127 cites W2122091775 @default.
• W3134810127 cites W2122386753 @default.
• W3134810127 cites W2123799914 @default.
• W3134810127 cites W2128187917 @default.
• W3134810127 cites W2138977668 @default.
• W3134810127 cites W2147080431 @default.
• W3134810127 cites W2148611175 @default.
• W3134810127 cites W2150951327 @default.
• W3134810127 cites W2154006092 @default.
• W3134810127 cites W2154245331 @default.
• W3134810127 cites W2192890134 @default.
• W3134810127 cites W2204298993 @default.
• W3134810127 cites W2213522766 @default.
• W3134810127 cites W2233632661 @default.
• W3134810127 cites W2244778532 @default.
• W3134810127 cites W2290552133 @default.
• W3134810127 cites W2325469858 @default.
• W3134810127 cites W2347191528 @default.
• W3134810127 cites W2394592434 @default.
• W3134810127 cites W2436013910 @default.
• W3134810127 cites W2461567180 @default.
• W3134810127 cites W2485662396 @default.
• W3134810127 cites W2499459691 @default.
• W3134810127 cites W2531425210 @default.
• W3134810127 cites W2568510753 @default.
• W3134810127 cites W2605928831 @default.
• W3134810127 cites W2722324655 @default.
• W3134810127 cites W2735379559 @default.
• W3134810127 cites W2751345613 @default.
• W3134810127 cites W2767651075 @default.
• W3134810127 cites W2807118307 @default.
• W3134810127 cites W2811453597 @default.
• W3134810127 cites W2893067191 @default.
• W3134810127 cites W2898719615 @default.
• W3134810127 cites W2901528306 @default.
• W3134810127 cites W2902385652 @default.

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