Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134833013> ?p ?o ?g. }
- W3134833013 abstract "Abstract Radiotherapy can effectively kill malignant cells, but the doses required to cure cancer patients may inflict severe collateral damage to adjacent healthy tissues. Recent technological advances in the clinical application has revitalized hyperthermia treatment (HT) as an option to improve radiotherapy (RT) outcomes. Understanding the synergistic effect of simultaneous thermoradiotherapy via mathematical modelling is essential for treatment planning. We here propose a theoretical model in which the thermal enhancement ratio (TER) relates to the cell fraction being radiosensitised by the infliction of sublethal damage through HT. Further damage finally kills the cell or abrogates its proliferative capacity in a non-reversible process. We suggest the TER to be proportional to the energy invested in the sensitisation, which is modelled as a simple rate process. Assuming protein denaturation as the main driver of HT-induced sublethal damage and considering the temperature dependence of the heat capacity of cellular proteins, the sensitisation rates were found to depend exponentially on temperature; in agreement with previous empirical observations. Our findings point towards an improved definition of thermal dose in concordance with the thermodynamics of protein denaturation. Our predictions well reproduce experimental in vitro and in vivo data, explaining the thermal modulation of cellular radioresponse for simultaneous thermoradiotherapy." @default.
- W3134833013 created "2021-03-15" @default.
- W3134833013 creator A5013403030 @default.
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- W3134833013 date "2021-03-09" @default.
- W3134833013 modified "2023-10-06" @default.
- W3134833013 title "Mathematical model for the thermal enhancement of radiation response: thermodynamic approach" @default.
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- W3134833013 cites W1529490909 @default.
- W3134833013 cites W1911698430 @default.
- W3134833013 cites W1952811152 @default.
- W3134833013 cites W1976800838 @default.
- W3134833013 cites W1987374417 @default.
- W3134833013 cites W1995480733 @default.
- W3134833013 cites W1999690799 @default.
- W3134833013 cites W2000105109 @default.
- W3134833013 cites W2000144812 @default.
- W3134833013 cites W2003894319 @default.
- W3134833013 cites W2004900984 @default.
- W3134833013 cites W2006428631 @default.
- W3134833013 cites W2019820853 @default.
- W3134833013 cites W202454568 @default.
- W3134833013 cites W2035616341 @default.
- W3134833013 cites W2051202148 @default.
- W3134833013 cites W2053984213 @default.
- W3134833013 cites W2057980421 @default.
- W3134833013 cites W2058946811 @default.
- W3134833013 cites W2068019583 @default.
- W3134833013 cites W2076232417 @default.
- W3134833013 cites W2078898216 @default.
- W3134833013 cites W2082675740 @default.
- W3134833013 cites W2083184030 @default.
- W3134833013 cites W2086213579 @default.
- W3134833013 cites W2095186700 @default.
- W3134833013 cites W2107865510 @default.
- W3134833013 cites W2108378525 @default.
- W3134833013 cites W2109557452 @default.
- W3134833013 cites W2110531575 @default.
- W3134833013 cites W2113614699 @default.
- W3134833013 cites W2123250747 @default.
- W3134833013 cites W2125039552 @default.
- W3134833013 cites W2145147037 @default.
- W3134833013 cites W2159322809 @default.
- W3134833013 cites W2169207156 @default.
- W3134833013 cites W2170558349 @default.
- W3134833013 cites W2172069323 @default.
- W3134833013 cites W2203923849 @default.
- W3134833013 cites W2259404274 @default.
- W3134833013 cites W2264266890 @default.
- W3134833013 cites W2279163054 @default.
- W3134833013 cites W2280954227 @default.
- W3134833013 cites W2284676862 @default.
- W3134833013 cites W2289223631 @default.
- W3134833013 cites W2316603021 @default.
- W3134833013 cites W2328584577 @default.
- W3134833013 cites W2532300564 @default.
- W3134833013 cites W2532981201 @default.
- W3134833013 cites W2606820115 @default.
- W3134833013 cites W2608624864 @default.
- W3134833013 cites W2623331846 @default.
- W3134833013 cites W2639458393 @default.
- W3134833013 cites W2752881483 @default.
- W3134833013 cites W2765730870 @default.
- W3134833013 cites W2772085199 @default.
- W3134833013 cites W2800526658 @default.
- W3134833013 cites W2806201495 @default.
- W3134833013 cites W2811438356 @default.
- W3134833013 cites W2889646458 @default.
- W3134833013 cites W2898105459 @default.
- W3134833013 cites W2909350868 @default.
- W3134833013 cites W2912413844 @default.
- W3134833013 cites W2945925864 @default.
- W3134833013 cites W2964416380 @default.
- W3134833013 cites W2965853123 @default.
- W3134833013 cites W2972582180 @default.
- W3134833013 cites W2981106427 @default.
- W3134833013 cites W2983183254 @default.
- W3134833013 cites W2985226090 @default.
- W3134833013 cites W2990242595 @default.
- W3134833013 cites W3004018419 @default.
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- W3134833013 cites W3009231574 @default.
- W3134833013 cites W3032943900 @default.
- W3134833013 cites W3047258241 @default.
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- W3134833013 doi "https://doi.org/10.1038/s41598-021-84620-z" @default.
- W3134833013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7970926" @default.
- W3134833013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33750833" @default.
- W3134833013 hasPublicationYear "2021" @default.
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