Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134837165> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3134837165 abstract "Brain derived neurotrophic factor (BDNF), signaling via its receptor Tropomyosin receptor kinase B (TrkB) plays a pivotal role in establishing and maintaining the structure and function of neurons within the central nervous system. Deficits in BDNF/TrkB signaling are reported to contribute to the pathogenesis of multiple major disorders, such as Alzheimer’s disease. While manipulating the BDNF/TrkB signaling has been shown to be a viable approach to ameliorate some of the symptoms in a variety of neurological and psychiatric disorders, effective delivery of BDNF into the brain is challenging due to its poor pharmacokinetic profile and clinical translation has fallen short. This triggered the development of BDNF mimetics which specifically activate the TrkB receptor. This work investigated whether a recently identified fully human TrkB agonist antibody (ZEB85) exerts similar biological functions to BDNF. It was shown that treatment with ZEB85 leads to TrkB phosphorylation and increases expression of the activity-dependent immediate early gene c-Fos. Further, ZEB85 significantly increases the neurite complexity of developing hippocampal neurons. Parvalbumin positive interneurons from hippocampal cultures deprived of BDNF have a severely altered dendritic phenotype which can be completely rescued by the TrkB agonist antibody. Moreover, ZEB85 leads to changes in spine number and morphology in mature neurons. Under pathological conditions, treatment with ZEB85 completely prevents amyloid-beta induced dendritic spine loss. Lastly, prolonged application of ZEB85 over several days in hippocampal organotypic slice cultures prepared from heterozygous bdnf knockout mice, known to have deficits in the induction and maintenance of long-term potentiation (LTP) improved these parameters. Taken together, ZEB85 indeed exerts some of the biological functions of BDNF as seen in TrkB activation and structural and functional changes of healthy and diseased neurons. However, when directly compared to BDNF, the effect of ZEB85 is less pronounced. Thus, this work provides an initial characterization of a new promising TrkB agonist suggesting its potential value for therapeutical applications." @default.
- W3134837165 created "2021-03-15" @default.
- W3134837165 creator A5080722888 @default.
- W3134837165 date "2021-03-02" @default.
- W3134837165 modified "2023-09-27" @default.
- W3134837165 title "Role of a novel TrkB agonist antibody in positively modulating the architecture and synaptic plasticity of hippocampal neurons in health and disease" @default.
- W3134837165 doi "https://doi.org/10.24355/dbbs.084-202103021527-0" @default.
- W3134837165 hasPublicationYear "2021" @default.
- W3134837165 type Work @default.
- W3134837165 sameAs 3134837165 @default.
- W3134837165 citedByCount "0" @default.
- W3134837165 crossrefType "dissertation" @default.
- W3134837165 hasAuthorship W3134837165A5080722888 @default.
- W3134837165 hasConcept C126322002 @default.
- W3134837165 hasConcept C148762608 @default.
- W3134837165 hasConcept C160539049 @default.
- W3134837165 hasConcept C169760540 @default.
- W3134837165 hasConcept C170493617 @default.
- W3134837165 hasConcept C174884520 @default.
- W3134837165 hasConcept C25274449 @default.
- W3134837165 hasConcept C2778790584 @default.
- W3134837165 hasConcept C2778938600 @default.
- W3134837165 hasConcept C2781161787 @default.
- W3134837165 hasConcept C56703729 @default.
- W3134837165 hasConcept C71924100 @default.
- W3134837165 hasConcept C86803240 @default.
- W3134837165 hasConcept C92020748 @default.
- W3134837165 hasConcept C97124661 @default.
- W3134837165 hasConcept C98229152 @default.
- W3134837165 hasConceptScore W3134837165C126322002 @default.
- W3134837165 hasConceptScore W3134837165C148762608 @default.
- W3134837165 hasConceptScore W3134837165C160539049 @default.
- W3134837165 hasConceptScore W3134837165C169760540 @default.
- W3134837165 hasConceptScore W3134837165C170493617 @default.
- W3134837165 hasConceptScore W3134837165C174884520 @default.
- W3134837165 hasConceptScore W3134837165C25274449 @default.
- W3134837165 hasConceptScore W3134837165C2778790584 @default.
- W3134837165 hasConceptScore W3134837165C2778938600 @default.
- W3134837165 hasConceptScore W3134837165C2781161787 @default.
- W3134837165 hasConceptScore W3134837165C56703729 @default.
- W3134837165 hasConceptScore W3134837165C71924100 @default.
- W3134837165 hasConceptScore W3134837165C86803240 @default.
- W3134837165 hasConceptScore W3134837165C92020748 @default.
- W3134837165 hasConceptScore W3134837165C97124661 @default.
- W3134837165 hasConceptScore W3134837165C98229152 @default.
- W3134837165 hasLocation W31348371651 @default.
- W3134837165 hasOpenAccess W3134837165 @default.
- W3134837165 hasPrimaryLocation W31348371651 @default.
- W3134837165 hasRelatedWork W1967887486 @default.
- W3134837165 hasRelatedWork W1988524644 @default.
- W3134837165 hasRelatedWork W2038374013 @default.
- W3134837165 hasRelatedWork W2055583081 @default.
- W3134837165 hasRelatedWork W2097557124 @default.
- W3134837165 hasRelatedWork W2158059993 @default.
- W3134837165 hasRelatedWork W2172270319 @default.
- W3134837165 hasRelatedWork W2395605680 @default.
- W3134837165 hasRelatedWork W2791354533 @default.
- W3134837165 hasRelatedWork W2888643892 @default.
- W3134837165 hasRelatedWork W2908747687 @default.
- W3134837165 hasRelatedWork W2914107124 @default.
- W3134837165 hasRelatedWork W2946000451 @default.
- W3134837165 hasRelatedWork W2961125063 @default.
- W3134837165 hasRelatedWork W2969472499 @default.
- W3134837165 hasRelatedWork W2970477631 @default.
- W3134837165 hasRelatedWork W2999437268 @default.
- W3134837165 hasRelatedWork W3000431095 @default.
- W3134837165 hasRelatedWork W3023624746 @default.
- W3134837165 hasRelatedWork W3036596229 @default.
- W3134837165 isParatext "false" @default.
- W3134837165 isRetracted "false" @default.
- W3134837165 magId "3134837165" @default.
- W3134837165 workType "dissertation" @default.