FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134843553> ?p ?o ?g. }

• W3134843553 endingPage "110961" @default.
• W3134843553 startingPage "110961" @default.
• W3134843553 abstract "Airborne polycyclic aromatic hydrocarbons (PAH) possess carcinogenic and endocrine disrupting properties linked to mammary tumorigenesis. These effects may be initiated during a prenatal period of susceptibility to PAH activation of the aryl hydrocarbon receptor (Ahr) and through downstream effects on estrogen receptor (Er) α.We hypothesized prenatal airborne PAH exposure induces sustained effects in female adult wild type BALB/cByj mice detected in the offspring (F1) and grandoffspring (F2) generation. We hypothesized these effects would include altered expression and epigenetic regulation of Erα and altered expression of aryl hydrocarbon receptor repressor (Ahrr, Ahrr/aryl hydrocarbon receptor nuclear translocator (Arnt), and breast cancer type 1 susceptibility (Brca1). Further, we hypothesized that PAH would induce precancerous outcomes such as epithelial cell proliferation and epithelial cell hyperplasia in mammary glands of adult female offspring and grandoffspring.Prenatal ambient PAH exposure lowered Erα mRNA expression (F1 and F2: p<0.001 for each) and induced methylation in the Erα promoter in mammary tissue in offspring and grandoffspring mice on postnatal day (PND) 60. Prenatal PAH lowered Brca1 mRNA (F1: p=0.002, F2: p=0.02); Erα mRNA was correlated with Brca1 (F1: r=0.42, p=0.02; F2: r=0.53, p=0.005). Prenatal PAH lowered Ahrr (F1: p=0.03, F2: p=0.009) and raised Arnt mRNA expression (F1: p=0.01, F2: p=0.03). Alterations in Erα mRNA (F2: p<0.0001) and Ahrr (F2: p=0.02) in the grandoffspring mice also occured by PND 28, and similarly occurred in the dam on postpartum day (PPD) 28. Finally, prenatal PAH was associated with higher mammary epithelial cell proliferation in the offspring (p=0.02), but not grandoffspring mice, without differences in the frequency of mammary cell hyperplasia. These results did not differ after adjustment by each candidate gene expression level.Prenatal PAH exposure induces DNA methylation and alters gene expression in the Erα-mediated pathway across generations, and suggests that functional outcomes such as mammary cell proliferation also may occur in offspring as a result." @default.
• W3134843553 created "2021-03-15" @default.
• W3134843553 creator A5003886881 @default.
• W3134843553 creator A5014520801 @default.
• W3134843553 creator A5016576057 @default.
• W3134843553 creator A5027015508 @default.
• W3134843553 creator A5042229914 @default.
• W3134843553 creator A5045806111 @default.
• W3134843553 creator A5055874543 @default.
• W3134843553 creator A5062821367 @default.
• W3134843553 creator A5073608044 @default.
• W3134843553 creator A5078271521 @default.
• W3134843553 date "2021-05-01" @default.
• W3134843553 modified "2023-10-01" @default.
• W3134843553 title "Prenatal polycyclic aromatic hydrocarbons, altered ERα pathway-related methylation and expression, and mammary epithelial cell proliferation in offspring and grandoffspring adult mice" @default.
• W3134843553 cites W1523335221 @default.
• W3134843553 cites W1534122645 @default.
• W3134843553 cites W1779158283 @default.
• W3134843553 cites W1996431759 @default.
• W3134843553 cites W1996613294 @default.
• W3134843553 cites W2006961531 @default.
• W3134843553 cites W2011649969 @default.
• W3134843553 cites W2013717277 @default.
• W3134843553 cites W2018712283 @default.
• W3134843553 cites W2022484411 @default.
• W3134843553 cites W2025439361 @default.
• W3134843553 cites W2031909185 @default.
• W3134843553 cites W2032248685 @default.
• W3134843553 cites W2042538195 @default.
• W3134843553 cites W2044258996 @default.
• W3134843553 cites W2051776375 @default.
• W3134843553 cites W2052351468 @default.
• W3134843553 cites W2055468037 @default.
• W3134843553 cites W2072201043 @default.
• W3134843553 cites W2072271141 @default.
• W3134843553 cites W2081229341 @default.
• W3134843553 cites W2091710306 @default.
• W3134843553 cites W2093174458 @default.
• W3134843553 cites W2107542271 @default.
• W3134843553 cites W2113437172 @default.
• W3134843553 cites W2116791732 @default.
• W3134843553 cites W2117183312 @default.
• W3134843553 cites W2122931853 @default.
• W3134843553 cites W2125770442 @default.
• W3134843553 cites W2126715263 @default.
• W3134843553 cites W2139088926 @default.
• W3134843553 cites W2153455967 @default.
• W3134843553 cites W2155668399 @default.
• W3134843553 cites W2158693623 @default.
• W3134843553 cites W2159334494 @default.
• W3134843553 cites W2159403020 @default.
• W3134843553 cites W2161506868 @default.
• W3134843553 cites W2164911922 @default.
• W3134843553 cites W2166609546 @default.
• W3134843553 cites W2194683123 @default.
• W3134843553 cites W2202782981 @default.
• W3134843553 cites W2280602969 @default.
• W3134843553 cites W2289308528 @default.
• W3134843553 cites W2290025431 @default.
• W3134843553 cites W2323736786 @default.
• W3134843553 cites W2417435518 @default.
• W3134843553 cites W2519912170 @default.
• W3134843553 cites W2538755729 @default.
• W3134843553 cites W2597272587 @default.
• W3134843553 cites W2602473427 @default.
• W3134843553 cites W2607054926 @default.
• W3134843553 cites W2612319939 @default.
• W3134843553 cites W2614518936 @default.
• W3134843553 cites W2621014315 @default.
• W3134843553 cites W2626325705 @default.
• W3134843553 cites W2727670543 @default.
• W3134843553 cites W2790989595 @default.
• W3134843553 cites W2805017622 @default.
• W3134843553 cites W2806929960 @default.
• W3134843553 cites W2807662106 @default.
• W3134843553 cites W2809263049 @default.
• W3134843553 cites W2809623297 @default.
• W3134843553 cites W2890653649 @default.
• W3134843553 cites W2893354060 @default.
• W3134843553 cites W2895512858 @default.
• W3134843553 cites W2923001939 @default.
• W3134843553 cites W2941252175 @default.
• W3134843553 cites W2943880517 @default.
• W3134843553 cites W2962873553 @default.
• W3134843553 cites W2969786335 @default.
• W3134843553 cites W2970761826 @default.
• W3134843553 cites W3011128536 @default.
• W3134843553 cites W3013032681 @default.
• W3134843553 cites W3043971596 @default.
• W3134843553 cites W3084366418 @default.
• W3134843553 cites W4296300797 @default.
• W3134843553 doi "https://doi.org/10.1016/j.envres.2021.110961" @default.
• W3134843553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8119355" @default.
• W3134843553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33675803" @default.
• W3134843553 hasPublicationYear "2021" @default.
• W3134843553 type Work @default.
• W3134843553 sameAs 3134843553 @default.
• W3134843553 citedByCount "11" @default.

• next