FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134860931> ?p ?o ?g. }

• W3134860931 endingPage "962" @default.
• W3134860931 startingPage "949" @default.
• W3134860931 abstract "Hypertension is closely related to myocardial injury. Long-term hypertension can cause myocardial injury. Therefore, it is very important to find drugs to treat myocardial injury caused by hypertension. The aim of present study is to investigate the effects and mechanisms of geniposide on myocardial injuries in spontaneously hypertensive rats (SHR) and H9c2 cells induced by NaCl solution.Male Wistar-Kyoto (WKY) and SHR rats were given different doses of geniposide (25 mg/kg/d or 50 mg/kg/d) or distilled water for three consecutive weeks. Meanwhile, an H9c2 cell line-injury model was established using a solution of 150 µmol/L NaCl for 8 h. The cardiac function and related indexes of rats were detected.The results showed that geniposide decreased the levels of COI and COIII, which promoted the phosphorylation of AMPK (p-AMPK) and enhanced the energy metabolism pathway. Geniposide improved myocardial apoptosis by regulating apoptotic proteins (p38, BAX and Bcl-2). Finally, heart function was regulated, and the markers of myocardial injury were decreased. Geniposide increased the viability of H9c2 cells treated with the NaCl solution and decreased the rate of apoptosis by regulating the levels of apoptotic proteins. Geniposide could activate energy metabolism signalling pathway (AMPK/SirT1/FOXO1) and reduce H9c2 cell apoptosis.Our results showed that the mechanisms by which geniposide improves myocardial injury in SHR may be through regulating the energy metabolism signalling pathway (AMPK/SirT1/FOXO1) and improving myocardial apoptosis by regulating apoptotic proteins." @default.
• W3134860931 created "2021-03-15" @default.
• W3134860931 creator A5001003076 @default.
• W3134860931 creator A5026984704 @default.
• W3134860931 creator A5039777376 @default.
• W3134860931 creator A5040283327 @default.
• W3134860931 creator A5051462279 @default.
• W3134860931 creator A5080143461 @default.
• W3134860931 creator A5081676943 @default.
• W3134860931 creator A5086492116 @default.
• W3134860931 date "2021-03-01" @default.
• W3134860931 modified "2023-10-15" @default.
• W3134860931 title "Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway" @default.
• W3134860931 cites W1577300587 @default.
• W3134860931 cites W1770643672 @default.
• W3134860931 cites W1966069425 @default.
• W3134860931 cites W1977258127 @default.
• W3134860931 cites W1995813639 @default.
• W3134860931 cites W2016752484 @default.
• W3134860931 cites W2022267544 @default.
• W3134860931 cites W2025844021 @default.
• W3134860931 cites W2034454985 @default.
• W3134860931 cites W2045911846 @default.
• W3134860931 cites W2084918981 @default.
• W3134860931 cites W2103446573 @default.
• W3134860931 cites W2105532922 @default.
• W3134860931 cites W2115835896 @default.
• W3134860931 cites W2133444149 @default.
• W3134860931 cites W2150278759 @default.
• W3134860931 cites W2167765818 @default.
• W3134860931 cites W2192294917 @default.
• W3134860931 cites W2367271341 @default.
• W3134860931 cites W2511192218 @default.
• W3134860931 cites W2739029052 @default.
• W3134860931 cites W2768079580 @default.
• W3134860931 cites W2791737775 @default.
• W3134860931 cites W2792807715 @default.
• W3134860931 cites W2883107381 @default.
• W3134860931 cites W2887633052 @default.
• W3134860931 cites W2894918225 @default.
• W3134860931 cites W2896058667 @default.
• W3134860931 cites W2896064410 @default.
• W3134860931 cites W2898774545 @default.
• W3134860931 cites W2899087954 @default.
• W3134860931 cites W2899457825 @default.
• W3134860931 cites W2904442971 @default.
• W3134860931 cites W2907108867 @default.
• W3134860931 cites W2913732507 @default.
• W3134860931 cites W2919841653 @default.
• W3134860931 cites W2954091256 @default.
• W3134860931 cites W3024009267 @default.
• W3134860931 cites W3034264963 @default.
• W3134860931 cites W3081161092 @default.
• W3134860931 cites W3091873357 @default.
• W3134860931 cites W3110707167 @default.
• W3134860931 cites W583307770 @default.
• W3134860931 doi "https://doi.org/10.2147/dddt.s292107" @default.
• W3134860931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7937395" @default.
• W3134860931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33688169" @default.
• W3134860931 hasPublicationYear "2021" @default.
• W3134860931 type Work @default.
• W3134860931 sameAs 3134860931 @default.
• W3134860931 citedByCount "6" @default.
• W3134860931 countsByYear W31348609312022 @default.
• W3134860931 countsByYear W31348609312023 @default.
• W3134860931 crossrefType "journal-article" @default.
• W3134860931 hasAuthorship W3134860931A5001003076 @default.
• W3134860931 hasAuthorship W3134860931A5026984704 @default.
• W3134860931 hasAuthorship W3134860931A5039777376 @default.
• W3134860931 hasAuthorship W3134860931A5040283327 @default.
• W3134860931 hasAuthorship W3134860931A5051462279 @default.
• W3134860931 hasAuthorship W3134860931A5080143461 @default.
• W3134860931 hasAuthorship W3134860931A5081676943 @default.
• W3134860931 hasAuthorship W3134860931A5086492116 @default.
• W3134860931 hasBestOaLocation W31348609311 @default.
• W3134860931 hasConcept C111566952 @default.
• W3134860931 hasConcept C126322002 @default.
• W3134860931 hasConcept C134018914 @default.
• W3134860931 hasConcept C184235292 @default.
• W3134860931 hasConcept C185592680 @default.
• W3134860931 hasConcept C190283241 @default.
• W3134860931 hasConcept C2778198053 @default.
• W3134860931 hasConcept C2780124434 @default.
• W3134860931 hasConcept C51551487 @default.
• W3134860931 hasConcept C55493867 @default.
• W3134860931 hasConcept C71924100 @default.
• W3134860931 hasConcept C97029542 @default.
• W3134860931 hasConcept C98274493 @default.
• W3134860931 hasConceptScore W3134860931C111566952 @default.
• W3134860931 hasConceptScore W3134860931C126322002 @default.
• W3134860931 hasConceptScore W3134860931C134018914 @default.
• W3134860931 hasConceptScore W3134860931C184235292 @default.
• W3134860931 hasConceptScore W3134860931C185592680 @default.
• W3134860931 hasConceptScore W3134860931C190283241 @default.
• W3134860931 hasConceptScore W3134860931C2778198053 @default.
• W3134860931 hasConceptScore W3134860931C2780124434 @default.
• W3134860931 hasConceptScore W3134860931C51551487 @default.
• W3134860931 hasConceptScore W3134860931C55493867 @default.

• next