FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134862497> ?p ?o ?g. }

• W3134862497 endingPage "1609" @default.
• W3134862497 startingPage "1599" @default.
• W3134862497 abstract "Abstract Introduction Interrogation of cancers with next‐generation sequencing (NGS) mutation panels has become widely utilized, identifying prognostic and actionable mutations. This study explored the value of expanded mutation analysis in appendix peritoneal metastases (APM). Methods Forty‐eight APM patients treated 2013–2018 were retrospectively collected from a registry. Fifty‐gene NGS analysis was performed in CLIA approved lab to obtain mutation profiles. All patients underwent cytoreductive surgery (CRS)/hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C. Peritoneal cancer index (PCI), optimal CRS, survival (overall survival [OS] and progression‐free survival [PFS]) data were collected. Survival analyses were performed on all APM, high‐grade (HG), and low grade (LG) subsets, evaluating the impact of specific mutations on the outcome. Results Eighty‐three percent of APM had a mutation identified. KRAS was most frequent, 65% (88% LG 42% HG) with GNAS identified in 92% of LG‐APM. SMAD4 and/or TP53 mutations occurred in 25% of APM with observed decreased OS (46 vs. 81 months p = .0029); worse in HG‐APM (26 vs. 49 months p = .0451). SMAD4 was associated with the most significant reduction in PFS in APM ( p = .0085). Actionable mutations were identified in 73% of APM patients. Conclusions Most frequent mutations were KRAS, TP53, and SMAD4, and actionable mutation detection was common. SMAD4 and TP53 were associated with decreased OS. NGS mutation profiling has potential utility in APM." @default.
• W3134862497 created "2021-03-15" @default.
• W3134862497 creator A5001537046 @default.
• W3134862497 creator A5020453205 @default.
• W3134862497 creator A5028222598 @default.
• W3134862497 creator A5028490620 @default.
• W3134862497 creator A5029599062 @default.
• W3134862497 creator A5039694201 @default.
• W3134862497 creator A5043700163 @default.
• W3134862497 creator A5053716945 @default.
• W3134862497 creator A5069699129 @default.
• W3134862497 creator A5071197251 @default.
• W3134862497 creator A5081673872 @default.
• W3134862497 date "2021-03-05" @default.
• W3134862497 modified "2023-10-10" @default.
• W3134862497 title "Exploring the prognostic and therapeutic utility of expanded mutation profiling in appendix peritoneal metastasis managed with CRS/HIPEC" @default.
• W3134862497 cites W1996121807 @default.
• W3134862497 cites W2000824768 @default.
• W3134862497 cites W2005348280 @default.
• W3134862497 cites W2018715641 @default.
• W3134862497 cites W2027216206 @default.
• W3134862497 cites W2034903741 @default.
• W3134862497 cites W2078428578 @default.
• W3134862497 cites W2082122246 @default.
• W3134862497 cites W2134142320 @default.
• W3134862497 cites W2141002545 @default.
• W3134862497 cites W2214455720 @default.
• W3134862497 cites W2262897715 @default.
• W3134862497 cites W2565185520 @default.
• W3134862497 cites W2591235712 @default.
• W3134862497 cites W2737225791 @default.
• W3134862497 cites W2792793299 @default.
• W3134862497 cites W2801956643 @default.
• W3134862497 cites W2802399208 @default.
• W3134862497 cites W2803049994 @default.
• W3134862497 cites W2902485272 @default.
• W3134862497 cites W2917857677 @default.
• W3134862497 cites W2927407059 @default.
• W3134862497 cites W2969236106 @default.
• W3134862497 cites W3001713806 @default.
• W3134862497 cites W3005467577 @default.
• W3134862497 cites W3009514965 @default.
• W3134862497 cites W3042431230 @default.
• W3134862497 cites W4252877098 @default.
• W3134862497 doi "https://doi.org/10.1002/jso.26439" @default.
• W3134862497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33667317" @default.
• W3134862497 hasPublicationYear "2021" @default.
• W3134862497 type Work @default.
• W3134862497 sameAs 3134862497 @default.
• W3134862497 citedByCount "3" @default.
• W3134862497 countsByYear W31348624972022 @default.
• W3134862497 countsByYear W31348624972023 @default.
• W3134862497 crossrefType "journal-article" @default.
• W3134862497 hasAuthorship W3134862497A5001537046 @default.
• W3134862497 hasAuthorship W3134862497A5020453205 @default.
• W3134862497 hasAuthorship W3134862497A5028222598 @default.
• W3134862497 hasAuthorship W3134862497A5028490620 @default.
• W3134862497 hasAuthorship W3134862497A5029599062 @default.
• W3134862497 hasAuthorship W3134862497A5039694201 @default.
• W3134862497 hasAuthorship W3134862497A5043700163 @default.
• W3134862497 hasAuthorship W3134862497A5053716945 @default.
• W3134862497 hasAuthorship W3134862497A5069699129 @default.
• W3134862497 hasAuthorship W3134862497A5071197251 @default.
• W3134862497 hasAuthorship W3134862497A5081673872 @default.
• W3134862497 hasConcept C104317684 @default.
• W3134862497 hasConcept C121608353 @default.
• W3134862497 hasConcept C126322002 @default.
• W3134862497 hasConcept C143998085 @default.
• W3134862497 hasConcept C207103383 @default.
• W3134862497 hasConcept C2779458272 @default.
• W3134862497 hasConcept C2780427987 @default.
• W3134862497 hasConcept C2781187634 @default.
• W3134862497 hasConcept C2994223192 @default.
• W3134862497 hasConcept C3019894029 @default.
• W3134862497 hasConcept C44249647 @default.
• W3134862497 hasConcept C526805850 @default.
• W3134862497 hasConcept C54355233 @default.
• W3134862497 hasConcept C71924100 @default.
• W3134862497 hasConcept C74231797 @default.
• W3134862497 hasConcept C86803240 @default.
• W3134862497 hasConcept C90924648 @default.
• W3134862497 hasConceptScore W3134862497C104317684 @default.
• W3134862497 hasConceptScore W3134862497C121608353 @default.
• W3134862497 hasConceptScore W3134862497C126322002 @default.
• W3134862497 hasConceptScore W3134862497C143998085 @default.
• W3134862497 hasConceptScore W3134862497C207103383 @default.
• W3134862497 hasConceptScore W3134862497C2779458272 @default.
• W3134862497 hasConceptScore W3134862497C2780427987 @default.
• W3134862497 hasConceptScore W3134862497C2781187634 @default.
• W3134862497 hasConceptScore W3134862497C2994223192 @default.
• W3134862497 hasConceptScore W3134862497C3019894029 @default.
• W3134862497 hasConceptScore W3134862497C44249647 @default.
• W3134862497 hasConceptScore W3134862497C526805850 @default.
• W3134862497 hasConceptScore W3134862497C54355233 @default.
• W3134862497 hasConceptScore W3134862497C71924100 @default.
• W3134862497 hasConceptScore W3134862497C74231797 @default.
• W3134862497 hasConceptScore W3134862497C86803240 @default.
• W3134862497 hasConceptScore W3134862497C90924648 @default.

• next