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• W3134870264 startingPage "1130" @default.
• W3134870264 abstract "Colorectal cancer (CRC) is one of the most common cancers in western countries. Its mortality rate varies greatly, depending on the stage of the disease. The main cause of CRC mortality is metastasis, which most commonly affects the liver. The role of tumor microenvironment in tumor initiation, progression and metastasis development has been widely studied. In this review we summarize the role of the tumor microenvironment in the liver pre-metastatic niche formation, paying attention to the distant cellular crosstalk mediated by exosomes. Moreover, and based on the prognostic and predictive capacity of alterations in the stromal compartment of tumors, we describe the role of tumor microenvironment cells and related liquid biopsy biomarkers in the delivery of precise medication for metastatic CRC. Finally, we evaluate the different clinical strategies to prevent and treat liver metastatic disease, based on the targeting of the tumor microenvironment. Specifically, targeting angiogenesis pathways and regulating immune response are two important research pipelines that are being widely developed and promise great benefits." @default.
• W3134870264 created "2021-03-15" @default.
• W3134870264 creator A5008409708 @default.
• W3134870264 creator A5043843634 @default.
• W3134870264 creator A5044964002 @default.
• W3134870264 creator A5077962453 @default.
• W3134870264 date "2021-03-06" @default.
• W3134870264 modified "2023-10-06" @default.
• W3134870264 title "Tumor Microenvironment in Metastatic Colorectal Cancer: The Arbitrator in Patients’ Outcome" @default.
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