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- W3134914071 abstract "Aims & Objectives: Dexmedetomidine, an alpha-2 agonist, has been increasingly used for sedation in neonates due to its lack of respiratory depressant effect. However, dexmedetomidine decreases the heart rate (HR), thereby increasing the risk of bradycardia. This study aims to characterize the impact of intravenous dexmedetomidine infusion on HR, mean arterial pressure (MAP), and on balance between the sympathetic/parasympathetic (S/PS) systems in critically ill neonates. Methods: We retrospectively included neonates (<28 days) admitted to the Pediatric Intensive Care Unit from one center in Canada, who received a dexmedetomidine infusion. Data was collected from a high-fidelity database that prospectively collects all data from the monitors. The S/PS balance was assessed by analyzing HR variability using the low/high frequency (LF/HF) ratio with neonate frequency band. The variables were compared at different times during the first 12 hours of infusion using ANOVA analyses and Dunnett’s test. Results: A total of 23 neonates were included. The average age was 16,65±7,42 days and the average birthweight was 3177±409,7g. When compared to baseline values, mean (SD) HR values decreased by 19±4 bpm (p=0.002) and MAP decreased by 8.6±2.5 mmHg (p=0.023) 12 hours following the initiation of dexmedetomidine infusion (0.4±0.2 mcg/kg/h). The LF/HF ratio decreased significantly (-0.53±0.37SD, p=0.022) during this period.Conclusions: The S/PS balance shifted toward the parasympathetic system in neonates receiving a dexmedetomidine infusion. Our next steps will be to analyze the dose and effect relationship, and to characterize the risk factors associated with a significant reduction in sympathetic control, which may cause dexmedetomidine-associated bradycardia and hypotension." @default.
- W3134914071 created "2021-03-15" @default.
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- W3134914071 date "2021-03-01" @default.
- W3134914071 modified "2023-10-02" @default.
- W3134914071 title "P0074 / #1810: HEMODYNAMIC EFFECTS OF DEXMEDETOMIDINE IN NEONATES IN THE PEDIATRIC INTENSIVE CARE UNIT." @default.
- W3134914071 doi "https://doi.org/10.1097/01.pcc.0000738640.96334.ad" @default.
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