Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134926696> ?p ?o ?g. }
- W3134926696 endingPage "349" @default.
- W3134926696 startingPage "336" @default.
- W3134926696 abstract "Abstract Hepatitis viruses are chief pathogens of hepatitis and end-stage liver diseases. Their replication and related pathogenic process highly rely on the host micro-environment and multiple cellular elements, including exosomes. Representing with a sort of cell-derived vesicle structure, exosomes were considered to be dispensable cellular components, even wastes. Along with advancing investigation, a specific profile of exosome in driving hepatitis viruses’ infection and hepatic disease progression is revealed. Exosomes greatly affect the pathogenesis of hepatitis viruses by mediating their replication and modulating the host immune responses. The characteristics of host exosomes are markedly changed after infection with hepatitis viruses. Exosomes released from hepatitis virus-infected cells can carry viral nucleic or protein components, thereby acting as an effective subterfuge for hepatitis viruses by participating in viral transportation and immune escape. On the contrary, immune cell-derived exosomes contribute toward the innate antiviral immune defense and virus eradication. There is growing evidence supporting the application of exosomal biomarkers for predicting disease progress or therapeutic outcome, while exosomal nanoshuttles are regarded as promising therapeutic options based on their delivery properties and immune compatibility. In this review, we summarize the biogenesis and secretion mechanism of exosomes, review the recent findings pertaining to the role of exosomes in the interplay between hepatitis viruses and innate immune responses, and conclude their potential in further therapeutic application." @default.
- W3134926696 created "2021-03-15" @default.
- W3134926696 creator A5014268039 @default.
- W3134926696 creator A5020995749 @default.
- W3134926696 creator A5022135205 @default.
- W3134926696 creator A5026222277 @default.
- W3134926696 creator A5054653331 @default.
- W3134926696 creator A5064755844 @default.
- W3134926696 creator A5083960636 @default.
- W3134926696 date "2021-03-04" @default.
- W3134926696 modified "2023-09-30" @default.
- W3134926696 title "Emerging role and therapeutic application of exosome in hepatitis virus infection and associated diseases" @default.
- W3134926696 cites W1526700155 @default.
- W3134926696 cites W1827156733 @default.
- W3134926696 cites W1833105288 @default.
- W3134926696 cites W1874379912 @default.
- W3134926696 cites W1915536483 @default.
- W3134926696 cites W1968138343 @default.
- W3134926696 cites W1971411291 @default.
- W3134926696 cites W1979333281 @default.
- W3134926696 cites W1983251711 @default.
- W3134926696 cites W1984466323 @default.
- W3134926696 cites W1985207716 @default.
- W3134926696 cites W1985752998 @default.
- W3134926696 cites W1986937860 @default.
- W3134926696 cites W1990741894 @default.
- W3134926696 cites W1994636867 @default.
- W3134926696 cites W1996969128 @default.
- W3134926696 cites W1997571827 @default.
- W3134926696 cites W1998079639 @default.
- W3134926696 cites W2001558817 @default.
- W3134926696 cites W2006350053 @default.
- W3134926696 cites W2006766179 @default.
- W3134926696 cites W2007013372 @default.
- W3134926696 cites W2007948224 @default.
- W3134926696 cites W2009519656 @default.
- W3134926696 cites W2017080063 @default.
- W3134926696 cites W2020717559 @default.
- W3134926696 cites W2023874666 @default.
- W3134926696 cites W2025897959 @default.
- W3134926696 cites W2027167191 @default.
- W3134926696 cites W2027983183 @default.
- W3134926696 cites W2028776321 @default.
- W3134926696 cites W2032665024 @default.
- W3134926696 cites W2041820736 @default.
- W3134926696 cites W2043892409 @default.
- W3134926696 cites W2045598455 @default.
- W3134926696 cites W2048765000 @default.
- W3134926696 cites W2054362443 @default.
- W3134926696 cites W2055791162 @default.
- W3134926696 cites W2056763152 @default.
- W3134926696 cites W2057332675 @default.
- W3134926696 cites W2058873141 @default.
- W3134926696 cites W2067215174 @default.
- W3134926696 cites W2072109464 @default.
- W3134926696 cites W2075727747 @default.
- W3134926696 cites W2084160761 @default.
- W3134926696 cites W2095564897 @default.
- W3134926696 cites W2107057287 @default.
- W3134926696 cites W2109057110 @default.
- W3134926696 cites W2111019629 @default.
- W3134926696 cites W2112002812 @default.
- W3134926696 cites W2113649995 @default.
- W3134926696 cites W2114007604 @default.
- W3134926696 cites W2115989226 @default.
- W3134926696 cites W2117740937 @default.
- W3134926696 cites W2119764013 @default.
- W3134926696 cites W2135457568 @default.
- W3134926696 cites W2138583492 @default.
- W3134926696 cites W2140690761 @default.
- W3134926696 cites W2143729276 @default.
- W3134926696 cites W2150904674 @default.
- W3134926696 cites W2157740023 @default.
- W3134926696 cites W2159714738 @default.
- W3134926696 cites W2202360990 @default.
- W3134926696 cites W2207469885 @default.
- W3134926696 cites W2208788834 @default.
- W3134926696 cites W2221448846 @default.
- W3134926696 cites W2261822942 @default.
- W3134926696 cites W2271511819 @default.
- W3134926696 cites W2290775492 @default.
- W3134926696 cites W2294857314 @default.
- W3134926696 cites W2318489603 @default.
- W3134926696 cites W2337529533 @default.
- W3134926696 cites W2363676876 @default.
- W3134926696 cites W2396799318 @default.
- W3134926696 cites W2399818463 @default.
- W3134926696 cites W2411798759 @default.
- W3134926696 cites W2465117483 @default.
- W3134926696 cites W2478627770 @default.
- W3134926696 cites W2508981910 @default.
- W3134926696 cites W2516639262 @default.
- W3134926696 cites W2529794991 @default.
- W3134926696 cites W2536336822 @default.
- W3134926696 cites W2549557444 @default.
- W3134926696 cites W2555314306 @default.
- W3134926696 cites W2577902692 @default.
- W3134926696 cites W2582829456 @default.