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- W3134928585 abstract "Three known compounds were isolated from Virgaria nigra CF-231658; 2,7-dihydroxy naphthalene (1), virgaricin B (2) and virgaricin (3). The isolated compounds was obtained from liquid-state and agar-supported fermentation using Amberlite XAD-16 solid-phase extraction during the cultivation step. Their structures were elucidated on the basis of 1D and 2D NMR as well as HRMS spectroscopic analyses. The isolated compounds were examined for their ability to inhibit elastase using normal human diploid fibroblasts. Compound 2 displayed the most potent activity with 76.7 ± 2.12% inhibition of the enzyme activity at 5 μM concentration." @default.
- W3134928585 created "2021-03-15" @default.
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- W3134928585 date "2021-03-11" @default.
- W3134928585 modified "2023-10-14" @default.
- W3134928585 title "Elastase inhibitory activity of secondary metabolites from the fungus <i>Virgaria nigra</i> CF-231658" @default.
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- W3134928585 doi "https://doi.org/10.1080/14786419.2021.1899175" @default.
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