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- W3134928914 endingPage "166117" @default.
- W3134928914 startingPage "166117" @default.
- W3134928914 abstract "White matter degeneration is an important pathophysiological event of the central nervous system that is collectively characterized by demyelination, oligodendrocyte loss, axonal degeneration and parenchymal changes that can result in sensory, motor, autonomic and cognitive impairments. White matter degeneration can occur due to a variety of causes including trauma, neurotoxic exposure, insufficient blood flow, neuroinflammation, and developmental and inherited neuropathies. Regardless of the etiology, the degeneration processes share similar pathologic features. In recent years, a plethora of cellular and molecular mechanisms have been identified for axon and oligodendrocyte degeneration including oxidative damage, calcium overload, neuroinflammatory events, activation of proteases, depletion of adenosine triphosphate and energy supply. Extensive efforts have been also made to develop neuroprotective and neuroregenerative approaches for white matter repair. However, less progress has been achieved in this area mainly due to the complexity and multifactorial nature of the degeneration processes. Here, we will provide a timely review on the current understanding of the cellular and molecular mechanisms of white matter degeneration and will also discuss recent pharmacological and cellular therapeutic approaches for white matter protection as well as axonal regeneration, oligodendrogenesis and remyelination." @default.
- W3134928914 created "2021-03-15" @default.
- W3134928914 creator A5026659699 @default.
- W3134928914 creator A5037043745 @default.
- W3134928914 creator A5090134535 @default.
- W3134928914 date "2021-06-01" @default.
- W3134928914 modified "2023-10-18" @default.
- W3134928914 title "Mechanisms and repair strategies for white matter degeneration in CNS injury and diseases" @default.
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