FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134933481> ?p ?o ?g. }

• W3134933481 abstract "Abstract The global emergence of SARS-CoV-2 has triggered numerous efforts to develop therapeutic options for COVID-19 pandemic. The main protease of SARS-CoV-2 (M pro ), which is a critical enzyme for transcription and replication of SARS-CoV-2, is a key target for therapeutic development against COVID-19. An organoselenium drug called ebselen has recently been demonstrated to have strong inhibition against M pro and antiviral activity but its molecular mode of action is unknown preventing further development. We have examined the binding modes of ebselen and its derivative in M pro via high resolution co-crystallography and investigated their chemical reactivity via mass spectrometry. Stronger M pro inhibition than ebselen and potent ability to rescue infected cells were observed for a number of ebselen derivatives. A free selenium atom bound with cysteine 145 of M pro catalytic dyad has been revealed by crystallographic studies of M pro with ebselen and MR6-31-2 suggesting hydrolysis of the enzyme bound organoselenium covalent adduct, formation of a phenolic by-product is confirmed by mass spectrometry. The target engagement of these compounds with an unprecedented mechanism of SARS-CoV-2 M pro inhibition suggests wider therapeutic applications of organo-selenium compounds in SARS-CoV-2 and other zoonotic beta -corona viruses." @default.
• W3134933481 created "2021-03-15" @default.
• W3134933481 creator A5001040265 @default.
• W3134933481 creator A5013550923 @default.
• W3134933481 creator A5030079515 @default.
• W3134933481 creator A5031753071 @default.
• W3134933481 creator A5051409435 @default.
• W3134933481 creator A5056028884 @default.
• W3134933481 creator A5060830739 @default.
• W3134933481 creator A5061840421 @default.
• W3134933481 creator A5072628018 @default.
• W3134933481 creator A5076476229 @default.
• W3134933481 date "2021-03-11" @default.
• W3134933481 modified "2023-10-16" @default.
• W3134933481 title "Novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives" @default.
• W3134933481 cites W1965476204 @default.
• W3134933481 cites W1982210031 @default.
• W3134933481 cites W1986584051 @default.
• W3134933481 cites W2036172228 @default.
• W3134933481 cites W2103854602 @default.
• W3134933481 cites W2122994276 @default.
• W3134933481 cites W2134931914 @default.
• W3134933481 cites W2144081223 @default.
• W3134933481 cites W2146080841 @default.
• W3134933481 cites W2154714625 @default.
• W3134933481 cites W2159211495 @default.
• W3134933481 cites W2611351260 @default.
• W3134933481 cites W2736124908 @default.
• W3134933481 cites W2903899730 @default.
• W3134933481 cites W2904506792 @default.
• W3134933481 cites W2936788142 @default.
• W3134933481 cites W2999304916 @default.
• W3134933481 cites W3003217347 @default.
• W3134933481 cites W3004280078 @default.
• W3134933481 cites W3005212621 @default.
• W3134933481 cites W3011701533 @default.
• W3134933481 cites W3015608194 @default.
• W3134933481 cites W3020300207 @default.
• W3134933481 cites W3023464695 @default.
• W3134933481 cites W3043431476 @default.
• W3134933481 cites W3049240861 @default.
• W3134933481 cites W3080390075 @default.
• W3134933481 cites W3084799711 @default.
• W3134933481 cites W3093768302 @default.
• W3134933481 doi "https://doi.org/10.1101/2021.03.11.434764" @default.
• W3134933481 hasPublicationYear "2021" @default.
• W3134933481 type Work @default.
• W3134933481 sameAs 3134933481 @default.
• W3134933481 citedByCount "0" @default.
• W3134933481 crossrefType "posted-content" @default.
• W3134933481 hasAuthorship W3134933481A5001040265 @default.
• W3134933481 hasAuthorship W3134933481A5013550923 @default.
• W3134933481 hasAuthorship W3134933481A5030079515 @default.
• W3134933481 hasAuthorship W3134933481A5031753071 @default.
• W3134933481 hasAuthorship W3134933481A5051409435 @default.
• W3134933481 hasAuthorship W3134933481A5056028884 @default.
• W3134933481 hasAuthorship W3134933481A5060830739 @default.
• W3134933481 hasAuthorship W3134933481A5061840421 @default.
• W3134933481 hasAuthorship W3134933481A5072628018 @default.
• W3134933481 hasAuthorship W3134933481A5076476229 @default.
• W3134933481 hasBestOaLocation W31349334811 @default.
• W3134933481 hasConcept C181199279 @default.
• W3134933481 hasConcept C185592680 @default.
• W3134933481 hasConcept C202751555 @default.
• W3134933481 hasConcept C21951064 @default.
• W3134933481 hasConcept C2776120743 @default.
• W3134933481 hasConcept C2776714187 @default.
• W3134933481 hasConcept C2777283782 @default.
• W3134933481 hasConcept C2778760513 @default.
• W3134933481 hasConcept C2779138974 @default.
• W3134933481 hasConcept C538909803 @default.
• W3134933481 hasConcept C55493867 @default.
• W3134933481 hasConcept C71240020 @default.
• W3134933481 hasConceptScore W3134933481C181199279 @default.
• W3134933481 hasConceptScore W3134933481C185592680 @default.
• W3134933481 hasConceptScore W3134933481C202751555 @default.
• W3134933481 hasConceptScore W3134933481C21951064 @default.
• W3134933481 hasConceptScore W3134933481C2776120743 @default.
• W3134933481 hasConceptScore W3134933481C2776714187 @default.
• W3134933481 hasConceptScore W3134933481C2777283782 @default.
• W3134933481 hasConceptScore W3134933481C2778760513 @default.
• W3134933481 hasConceptScore W3134933481C2779138974 @default.
• W3134933481 hasConceptScore W3134933481C538909803 @default.
• W3134933481 hasConceptScore W3134933481C55493867 @default.
• W3134933481 hasConceptScore W3134933481C71240020 @default.
• W3134933481 hasLocation W31349334811 @default.
• W3134933481 hasOpenAccess W3134933481 @default.
• W3134933481 hasPrimaryLocation W31349334811 @default.
• W3134933481 hasRelatedWork W1990152330 @default.
• W3134933481 hasRelatedWork W1999398565 @default.
• W3134933481 hasRelatedWork W2007350025 @default.
• W3134933481 hasRelatedWork W2070828985 @default.
• W3134933481 hasRelatedWork W2093155820 @default.
• W3134933481 hasRelatedWork W2106220465 @default.
• W3134933481 hasRelatedWork W2491451478 @default.
• W3134933481 hasRelatedWork W2902450153 @default.
• W3134933481 hasRelatedWork W4248713218 @default.
• W3134933481 hasRelatedWork W836183878 @default.
• W3134933481 isParatext "false" @default.
• W3134933481 isRetracted "false" @default.

• next