FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134938430> ?p ?o ?g. }

• W3134938430 endingPage "3615" @default.
• W3134938430 startingPage "3604" @default.
• W3134938430 abstract "Venetoclax is a highly potent, selective BCL2 inhibitor capable of inducing apoptosis in cells dependent on BCL2 for survival. Most myeloma is MCL1-dependent; however, a subset of myeloma enriched for translocation t(11;14) is codependent on BCL2 and thus sensitive to venetoclax. The biology underlying this heterogeneity remains poorly understood. We show that knockdown of cyclin D1 does not induce resistance to venetoclax, arguing against a direct role for cyclin D1 in venetoclax sensitivity. To identify other factors contributing to venetoclax response, we studied a panel of 31 myeloma cell lines and 25 patient samples tested for venetoclax sensitivity. In cell lines, we corroborated our previous observation that BIM binding to BCL2 correlates with venetoclax response and further showed that knockout of BIM results in decreased venetoclax sensitivity. RNA-sequencing analysis identified expression of B-cell genes as enriched in venetoclax-sensitive myeloma, although no single gene consistently delineated sensitive and resistant cells. However, a panel of cell surface makers correlated well with ex vivo prediction of venetoclax response in 21 patient samples and may serve as a biomarker independent of t(11;14). Assay for transposase-accessible chromatin sequencing of myeloma cell lines also identified an epigenetic program in venetoclax-sensitive cells that was more similar to B cells than that of venetoclax-resistant cells, as well as enrichment for basic leucine zipper domain-binding motifs such as BATF. Together, these data indicate that remnants of B-cell biology are associated with BCL2 dependency and point to novel biomarkers of venetoclax-sensitive myeloma independent of t(11;14)." @default.
• W3134938430 created "2021-03-15" @default.
• W3134938430 creator A5007228982 @default.
• W3134938430 creator A5012712111 @default.
• W3134938430 creator A5021230077 @default.
• W3134938430 creator A5022520524 @default.
• W3134938430 creator A5023276777 @default.
• W3134938430 creator A5027607604 @default.
• W3134938430 creator A5038076013 @default.
• W3134938430 creator A5043365593 @default.
• W3134938430 creator A5046430988 @default.
• W3134938430 creator A5065983657 @default.
• W3134938430 creator A5066865482 @default.
• W3134938430 creator A5070011974 @default.
• W3134938430 creator A5077897003 @default.
• W3134938430 creator A5085850492 @default.
• W3134938430 creator A5086370228 @default.
• W3134938430 creator A5088696429 @default.
• W3134938430 date "2021-03-01" @default.
• W3134938430 modified "2023-10-15" @default.
• W3134938430 title "Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression" @default.
• W3134938430 cites W1933867057 @default.
• W3134938430 cites W1970521173 @default.
• W3134938430 cites W1982846895 @default.
• W3134938430 cites W1983470364 @default.
• W3134938430 cites W1988622164 @default.
• W3134938430 cites W1989929255 @default.
• W3134938430 cites W2034834612 @default.
• W3134938430 cites W2036411709 @default.
• W3134938430 cites W2047604395 @default.
• W3134938430 cites W2049457454 @default.
• W3134938430 cites W2050702798 @default.
• W3134938430 cites W2057942504 @default.
• W3134938430 cites W2061425058 @default.
• W3134938430 cites W2064759291 @default.
• W3134938430 cites W2095109339 @default.
• W3134938430 cites W2099410111 @default.
• W3134938430 cites W2122589790 @default.
• W3134938430 cites W2129757408 @default.
• W3134938430 cites W2155165473 @default.
• W3134938430 cites W2155624057 @default.
• W3134938430 cites W2172242534 @default.
• W3134938430 cites W2192121806 @default.
• W3134938430 cites W2215425676 @default.
• W3134938430 cites W2291176625 @default.
• W3134938430 cites W2409562298 @default.
• W3134938430 cites W2413787459 @default.
• W3134938430 cites W2485824342 @default.
• W3134938430 cites W2517879814 @default.
• W3134938430 cites W2520922516 @default.
• W3134938430 cites W2534349779 @default.
• W3134938430 cites W2584063241 @default.
• W3134938430 cites W2615497162 @default.
• W3134938430 cites W2746367132 @default.
• W3134938430 cites W2761234508 @default.
• W3134938430 cites W2791193037 @default.
• W3134938430 cites W2803895816 @default.
• W3134938430 cites W2892573863 @default.
• W3134938430 cites W2897811394 @default.
• W3134938430 cites W2904226822 @default.
• W3134938430 cites W2905070646 @default.
• W3134938430 cites W2914157523 @default.
• W3134938430 cites W4252175385 @default.
• W3134938430 doi "https://doi.org/10.1182/blood.2020007899" @default.
• W3134938430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8462405" @default.
• W3134938430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33649772" @default.
• W3134938430 hasPublicationYear "2021" @default.
• W3134938430 type Work @default.
• W3134938430 sameAs 3134938430 @default.
• W3134938430 citedByCount "32" @default.
• W3134938430 countsByYear W31349384302021 @default.
• W3134938430 countsByYear W31349384302022 @default.
• W3134938430 countsByYear W31349384302023 @default.
• W3134938430 crossrefType "journal-article" @default.
• W3134938430 hasAuthorship W3134938430A5007228982 @default.
• W3134938430 hasAuthorship W3134938430A5012712111 @default.
• W3134938430 hasAuthorship W3134938430A5021230077 @default.
• W3134938430 hasAuthorship W3134938430A5022520524 @default.
• W3134938430 hasAuthorship W3134938430A5023276777 @default.
• W3134938430 hasAuthorship W3134938430A5027607604 @default.
• W3134938430 hasAuthorship W3134938430A5038076013 @default.
• W3134938430 hasAuthorship W3134938430A5043365593 @default.
• W3134938430 hasAuthorship W3134938430A5046430988 @default.
• W3134938430 hasAuthorship W3134938430A5065983657 @default.
• W3134938430 hasAuthorship W3134938430A5066865482 @default.
• W3134938430 hasAuthorship W3134938430A5070011974 @default.
• W3134938430 hasAuthorship W3134938430A5077897003 @default.
• W3134938430 hasAuthorship W3134938430A5085850492 @default.
• W3134938430 hasAuthorship W3134938430A5086370228 @default.
• W3134938430 hasAuthorship W3134938430A5088696429 @default.
• W3134938430 hasBestOaLocation W31349384301 @default.
• W3134938430 hasConcept C203014093 @default.
• W3134938430 hasConcept C2776364478 @default.
• W3134938430 hasConcept C2777938653 @default.
• W3134938430 hasConcept C2778461978 @default.
• W3134938430 hasConcept C2779675984 @default.
• W3134938430 hasConcept C502942594 @default.
• W3134938430 hasConcept C86803240 @default.

• next