FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134939107> ?p ?o ?g. }

• W3134939107 endingPage "2613" @default.
• W3134939107 startingPage "2613" @default.
• W3134939107 abstract "A regio- and diastereoselective synthesis of two types of dispiro derivatives of 2-selenoxoimidazolidin-4-ones, differing in the position of the nitrogen atom in the central pyrrolidine ring of the spiro-fused system—namely, 2-selenoxodispiro[imidazolidine-4,3′-pyrrolidine-2′,3″-indoline]-2″,5-diones (5a-h) and 2-senenoxodispiro[imidazolidine-4,3′-pyrrolidine-4′,3″-indoline]-2″,5-diones (6a-m)—were developed based on a 1,3-dipolar cycloaddition of azomethine ylides generated from isatin and sarcosine or formaldehyde and sarcosine to 5-arylidene or 5-indolidene-2-selenoxo-tetrahydro-4H-imidazole-4-ones. Selenium-containing dispiro indolinones generally exhibit cytotoxic activity near to the activity of the corresponding oxygen and sulfur-containing derivatives. Compounds 5b, 5c, and 5e demonstrated considerable in vitro cytotoxicity in the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) test (concentration of compounds that caused 50% death of cells (CC50) 7.6–8.7 μM) against the A549 cancer cell line with the VA13/A549 selectivity index 5.2–6.9; some compounds (5 and 6) increased the level of intracellular reactive oxygen species (ROS) in the experiment on A549 and PC3 cells using platinized carbon nanoelectrode. The tests for p53 activation for compounds 5 and 6 on the transcriptional reporter suggest that the investigated compounds can only have an indirect p53-dependent mechanism of action. For the compounds 5b, 6b, and 6l, the ROS generation may be one of the significant mechanisms of their cytotoxic action." @default.
• W3134939107 created "2021-03-15" @default.
• W3134939107 creator A5007177081 @default.
• W3134939107 creator A5017326542 @default.
• W3134939107 creator A5027774145 @default.
• W3134939107 creator A5030065847 @default.
• W3134939107 creator A5030148263 @default.
• W3134939107 creator A5031026495 @default.
• W3134939107 creator A5042552875 @default.
• W3134939107 creator A5043075366 @default.
• W3134939107 creator A5060167300 @default.
• W3134939107 creator A5072158785 @default.
• W3134939107 creator A5073969958 @default.
• W3134939107 creator A5074641896 @default.
• W3134939107 creator A5079798259 @default.
• W3134939107 creator A5082370641 @default.
• W3134939107 date "2021-03-05" @default.
• W3134939107 modified "2023-10-17" @default.
• W3134939107 title "Dispirooxindoles Based on 2-Selenoxo-Imidazolidin-4-Ones: Synthesis, Cytotoxicity and ROS Generation Ability" @default.
• W3134939107 cites W1757407923 @default.
• W3134939107 cites W1967645410 @default.
• W3134939107 cites W1971014175 @default.
• W3134939107 cites W1973110823 @default.
• W3134939107 cites W1973829219 @default.
• W3134939107 cites W1973872488 @default.
• W3134939107 cites W1984143603 @default.
• W3134939107 cites W1989565001 @default.
• W3134939107 cites W2018385269 @default.
• W3134939107 cites W2020571246 @default.
• W3134939107 cites W2037574562 @default.
• W3134939107 cites W2052597368 @default.
• W3134939107 cites W2054074966 @default.
• W3134939107 cites W2057423855 @default.
• W3134939107 cites W2058891784 @default.
• W3134939107 cites W2074807618 @default.
• W3134939107 cites W2079118765 @default.
• W3134939107 cites W2090575388 @default.
• W3134939107 cites W2092073124 @default.
• W3134939107 cites W2094305716 @default.
• W3134939107 cites W2102056087 @default.
• W3134939107 cites W2114918609 @default.
• W3134939107 cites W2121538550 @default.
• W3134939107 cites W2123327119 @default.
• W3134939107 cites W2128240743 @default.
• W3134939107 cites W2132672740 @default.
• W3134939107 cites W2147434890 @default.
• W3134939107 cites W2155829268 @default.
• W3134939107 cites W2162542545 @default.
• W3134939107 cites W2207504105 @default.
• W3134939107 cites W2233544868 @default.
• W3134939107 cites W2253996148 @default.
• W3134939107 cites W2287940265 @default.
• W3134939107 cites W2318011020 @default.
• W3134939107 cites W2397428234 @default.
• W3134939107 cites W2538051933 @default.
• W3134939107 cites W2756856565 @default.
• W3134939107 cites W2793799864 @default.
• W3134939107 cites W2803119036 @default.
• W3134939107 cites W2805723146 @default.
• W3134939107 cites W2810021106 @default.
• W3134939107 cites W2892909323 @default.
• W3134939107 cites W2940689067 @default.
• W3134939107 cites W2949392334 @default.
• W3134939107 cites W2949795865 @default.
• W3134939107 cites W2953143421 @default.
• W3134939107 cites W3006017099 @default.
• W3134939107 cites W3031645880 @default.
• W3134939107 cites W3037962981 @default.
• W3134939107 cites W3089175372 @default.
• W3134939107 cites W3093756348 @default.
• W3134939107 doi "https://doi.org/10.3390/ijms22052613" @default.
• W3134939107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7961907" @default.
• W3134939107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33807662" @default.
• W3134939107 hasPublicationYear "2021" @default.
• W3134939107 type Work @default.
• W3134939107 sameAs 3134939107 @default.
• W3134939107 citedByCount "8" @default.
• W3134939107 countsByYear W31349391072021 @default.
• W3134939107 countsByYear W31349391072022 @default.
• W3134939107 countsByYear W31349391072023 @default.
• W3134939107 crossrefType "journal-article" @default.
• W3134939107 hasAuthorship W3134939107A5007177081 @default.
• W3134939107 hasAuthorship W3134939107A5017326542 @default.
• W3134939107 hasAuthorship W3134939107A5027774145 @default.
• W3134939107 hasAuthorship W3134939107A5030065847 @default.
• W3134939107 hasAuthorship W3134939107A5030148263 @default.
• W3134939107 hasAuthorship W3134939107A5031026495 @default.
• W3134939107 hasAuthorship W3134939107A5042552875 @default.
• W3134939107 hasAuthorship W3134939107A5043075366 @default.
• W3134939107 hasAuthorship W3134939107A5060167300 @default.
• W3134939107 hasAuthorship W3134939107A5072158785 @default.
• W3134939107 hasAuthorship W3134939107A5073969958 @default.
• W3134939107 hasAuthorship W3134939107A5074641896 @default.
• W3134939107 hasAuthorship W3134939107A5079798259 @default.
• W3134939107 hasAuthorship W3134939107A5082370641 @default.
• W3134939107 hasBestOaLocation W31349391071 @default.
• W3134939107 hasConcept C109316439 @default.
• W3134939107 hasConcept C178790620 @default.

• next