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- W3134946178 endingPage "105003" @default.
- W3134946178 startingPage "105003" @default.
- W3134946178 abstract "Parkinson's disease is a neurodegenerative disease, the treatment of which is mainly centred around supplementation of dopamine. Additional targets have been identified and newer chemotherapeutic agents have been introduced but their clinical efficacy is limited due to solubility, bioavailability issues and inability to cross the blood-brain barrier (BBB). A wide range of biomaterials ranging from biomolecules, polymers, inorganic metal and metal oxide nanoparticles have been employed to assist the delivery of these therapeutic agents into the brain. Additionally, strategies to deliver cells to restore the dopaminergic neurons also have shown promise due to the integration of biocompatible materials that aid neurogenesis through a combination of topographical, chemical and mechanical cues. Neuroprosthetics is an area that may become significant in treatment of motor deficits associated with Parkinson's disease, and involves development of highly conductive and robust electrode materials with excellent cytocompatibility. This review summarizes the major role played by biomaterials in design of novel strategies and in the improvement of existing therapeutic methods as well as the emerging trends in this domain. • Conventional therapy for Parkinson's disease is ineffective owing to side-effects. • Use of nanodelivery systems improve solubility, bioavailability and blood-brain barrier permeability. • Cell replacement therapy augmented through use of scaffolds and neurotropic factors. • Gene therapy aims to induce dopamine production or inhibit dopamine depleting enzymes. • Multi-target strategies using intelligent combination of materials can improve therapeutic outcome in Parkinson’s disease." @default.
- W3134946178 created "2021-03-15" @default.
- W3134946178 creator A5074577272 @default.
- W3134946178 date "2021-05-01" @default.
- W3134946178 modified "2023-09-27" @default.
- W3134946178 title "Biomaterials in the treatment of Parkinson's disease" @default.
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