FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134957406> ?p ?o ?g. }

• W3134957406 endingPage "67" @default.
• W3134957406 startingPage "56" @default.
• W3134957406 abstract "ABSTRACT Background: Increased concentrations of serum proteins in cerebrospinal fluid (CSF) are interpreted as blood-CSF barrier dysfunction. Frequently used interpretations such as barrier leakage, disruption or breakdown contradict CSF protein data, which suggest a reduced CSF flow rate as the cause. Results: Even the severest barrier dysfunctions do not change the molecular size-dependent selectivity or the interindividual variation of the protein transfer across barriers. Serum protein concentrations in lumbar CSF increase with hyperbolic functions, but the levels of proteins that do not pass the barrier remain constant (brain proteins) or increase linearly (leptomeningal proteins). All CSF protein dynamics above and below a lumbar blockade can also be explained, independent of their barrier passage, by a reduced caudally directed flow. Local accumulation of gadolinium in multiple sclerosis (MS) is now understood as due to reduced bulk flow elimination by interstitial fluid (ISF). Nonlinear change of the steady state in barrier dysfunction and along normal rostro-caudal gradients supports the diffusion/flow model and contradicts obstructions of diffusion pathways. Regardless of the cause of the disease, pathophysiological flow blockages are found in bacterial meningitis, leukemia, meningeal carcinomatosis, Guillain-Barré syndrome, MS and experimental allergic encephalomyelitis. In humans, the fortyfold higher albumin concentrations in early fetal development decrease later with maturation of the arachnoid villi, i.e., with beginning CSF outflow, which contradicts a relevant outflow to the lymphatic system. Respiration- and heartbeat-dependent oscillations do not disturb net direction of CSF flow. Conclusion: Blood-CSF and blood-brain barrier dysfunctions are an expression of reduced CSF or ISF flow rate." @default.
• W3134957406 created "2021-03-15" @default.
• W3134957406 creator A5048516238 @default.
• W3134957406 date "2021-01-01" @default.
• W3134957406 modified "2023-09-29" @default.
• W3134957406 title "Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data" @default.
• W3134957406 cites W1484084400 @default.
• W3134957406 cites W1500954646 @default.
• W3134957406 cites W1571706135 @default.
• W3134957406 cites W1589691430 @default.
• W3134957406 cites W1796054280 @default.
• W3134957406 cites W1967138600 @default.
• W3134957406 cites W1973294015 @default.
• W3134957406 cites W1977720801 @default.
• W3134957406 cites W1992171900 @default.
• W3134957406 cites W1994183414 @default.
• W3134957406 cites W2001535098 @default.
• W3134957406 cites W2015065886 @default.
• W3134957406 cites W2017654980 @default.
• W3134957406 cites W2019675628 @default.
• W3134957406 cites W2035536036 @default.
• W3134957406 cites W2039378498 @default.
• W3134957406 cites W2039583391 @default.
• W3134957406 cites W2044389533 @default.
• W3134957406 cites W2046026976 @default.
• W3134957406 cites W2065496524 @default.
• W3134957406 cites W2067996069 @default.
• W3134957406 cites W2074485666 @default.
• W3134957406 cites W2080371558 @default.
• W3134957406 cites W2086621268 @default.
• W3134957406 cites W2088566422 @default.
• W3134957406 cites W2091409373 @default.
• W3134957406 cites W2096525076 @default.
• W3134957406 cites W2115687133 @default.
• W3134957406 cites W2119839026 @default.
• W3134957406 cites W2125136428 @default.
• W3134957406 cites W2126722701 @default.
• W3134957406 cites W2139314114 @default.
• W3134957406 cites W2143795852 @default.
• W3134957406 cites W2159821105 @default.
• W3134957406 cites W2160333751 @default.
• W3134957406 cites W2167127477 @default.
• W3134957406 cites W2168677679 @default.
• W3134957406 cites W2263348606 @default.
• W3134957406 cites W2278822899 @default.
• W3134957406 cites W2314709739 @default.
• W3134957406 cites W2336448195 @default.
• W3134957406 cites W2441449165 @default.
• W3134957406 cites W2584813339 @default.
• W3134957406 cites W2614660981 @default.
• W3134957406 cites W2615488595 @default.
• W3134957406 cites W2766641868 @default.
• W3134957406 cites W2887138305 @default.
• W3134957406 cites W2892061688 @default.
• W3134957406 cites W2919675366 @default.
• W3134957406 cites W2964086052 @default.
• W3134957406 cites W3112146875 @default.
• W3134957406 doi "https://doi.org/10.1590/0004-282x-anp-2020-0094" @default.
• W3134957406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33656113" @default.
• W3134957406 hasPublicationYear "2021" @default.
• W3134957406 type Work @default.
• W3134957406 sameAs 3134957406 @default.
• W3134957406 citedByCount "11" @default.
• W3134957406 countsByYear W31349574062021 @default.
• W3134957406 countsByYear W31349574062022 @default.
• W3134957406 countsByYear W31349574062023 @default.
• W3134957406 crossrefType "journal-article" @default.
• W3134957406 hasAuthorship W3134957406A5048516238 @default.
• W3134957406 hasBestOaLocation W31349574062 @default.
• W3134957406 hasConcept C126322002 @default.
• W3134957406 hasConcept C134018914 @default.
• W3134957406 hasConcept C142724271 @default.
• W3134957406 hasConcept C146543888 @default.
• W3134957406 hasConcept C185592680 @default.
• W3134957406 hasConcept C2776125364 @default.
• W3134957406 hasConcept C2778402981 @default.
• W3134957406 hasConcept C2779651940 @default.
• W3134957406 hasConcept C33619753 @default.
• W3134957406 hasConcept C529278444 @default.
• W3134957406 hasConcept C71924100 @default.
• W3134957406 hasConceptScore W3134957406C126322002 @default.
• W3134957406 hasConceptScore W3134957406C134018914 @default.
• W3134957406 hasConceptScore W3134957406C142724271 @default.
• W3134957406 hasConceptScore W3134957406C146543888 @default.
• W3134957406 hasConceptScore W3134957406C185592680 @default.
• W3134957406 hasConceptScore W3134957406C2776125364 @default.
• W3134957406 hasConceptScore W3134957406C2778402981 @default.
• W3134957406 hasConceptScore W3134957406C2779651940 @default.
• W3134957406 hasConceptScore W3134957406C33619753 @default.
• W3134957406 hasConceptScore W3134957406C529278444 @default.
• W3134957406 hasConceptScore W3134957406C71924100 @default.
• W3134957406 hasIssue "1" @default.
• W3134957406 hasLocation W31349574061 @default.
• W3134957406 hasLocation W31349574062 @default.
• W3134957406 hasOpenAccess W3134957406 @default.
• W3134957406 hasPrimaryLocation W31349574061 @default.
• W3134957406 hasRelatedWork W2054410015 @default.
• W3134957406 hasRelatedWork W2056772426 @default.

• next