Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134967225> ?p ?o ?g. }
- W3134967225 endingPage "59" @default.
- W3134967225 startingPage "20" @default.
- W3134967225 abstract "Initially thought to be useful only to reach tissues in the immediate vicinity of the CSF circulatory system, CSF circulation is now increasingly viewed as a viable pathway to deliver certain therapeutics deeper into brain tissues. There is emerging evidence that this goal is achievable in the case of large therapeutic proteins, provided conditions are met that are described herein. We show how fluid dynamic modeling helps predict infusion rate and duration to overcome high CSF turnover. We posit that despite model limitations and controversies, fluid dynamic models, pharmacokinetic models, preclinical testing, and a qualitative understanding of the glymphatic system circulation can be used to estimate drug penetration in brain tissues. Lastly, in addition to highlighting landmark scientific and medical literature, we provide practical advice on formulation development, device selection, and pharmacokinetic modeling. Our review of clinical studies suggests a growing interest for intra-CSF delivery, particularly for targeted proteins." @default.
- W3134967225 created "2021-03-15" @default.
- W3134967225 creator A5002576203 @default.
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- W3134967225 creator A5039890806 @default.
- W3134967225 creator A5054287145 @default.
- W3134967225 date "2021-06-01" @default.
- W3134967225 modified "2023-10-14" @default.
- W3134967225 title "Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues" @default.
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