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- W3134970335 abstract "TMA is a pathological process involving thrombocytopenia, microangiopathic haemolytic anemia and microvascularocclusion. TMA belongs to thrombocytopenia associated multi-organ failure(TAMOF) syndromes and therefore itsdiagnosis should be considered in critically ill children. TMA is life threatening resulting from ischemic multiorganfailure and characterized by its diversity and high ICU mortality rate ~ 20%, despite appropriate treatment [1,2].It can manifest in diverse range of conditions and presentations but AKI is a common prominent feature becauseof apparent propensity of the glomerular circulation to endothelial damage and occlusion. The most frequentTMA syndromes reported in children are haemolytic uraemic syndrome (HUS), in which renal impairement is theprominent clinical feature. Thrombotic thrombocytopenic purpura (TTP), another TMA syndrome also occurs inchildren often associated with cerebral involvement.(Secondary TMA are defined as TMA occurring with otherco-morbidities serving as the trigerring events. These include severe infections, autoimmunity, haematopoieticprogenitor cells or solid organ transplantations, malignancy and drugs. Therefore the diagnosis of secondary TMAcan be extremely challenging. Here we present a diagnostic approach to a previously healthy 13Yrs old male childwho presented in emergency with breathing difficulty, decreased oral acceptance, lethargy and altered sensorium forpast one day, later found to have azotemia and anion gap metabolic acidosis." @default.
- W3134970335 created "2021-03-15" @default.
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- W3134970335 date "2021-01-01" @default.
- W3134970335 modified "2023-09-28" @default.
- W3134970335 title "Paediatric Thrombotic Microangiopathy with AKI secondary to aHUS" @default.
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